Results 121 to 130 of about 1,603,529 (309)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Empirical Threshold Values for Quantitative Trait Mapping [PDF]
, 1994 32 pages, 1 article*Empirical Threshold Values for Quantitative Trait Mapping* (Churchill, G. A.; Doerge, R.
Cornell University. Dept. of Biological Statistics and Computational Biology. +4 more
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Threshold values in groundwater: for which substances?
, 2006 Threshold values for groundwater are mandatory for the (European) Water Framework Directive. No European procedures will be given for substances for which threshold values have to be established, nor for the level of threshold values.
Verweij W, Reijnders HFR
core
A mathematical approach to define threshold values of pavement characteristics
, 2014 Transportation authorities managing road networks have to define threshold values of acceptance for pavement surface characteristics. This procedure is either based on relevant experience or drawn from a combination of subjective ranking and monitoring ...
Papageorgiou, G. P., Mouratidis, A.
core +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Dependency of distribution parameters on threshold values.
, 2012 (a) The values of with different threshold values of 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, and 1.4 times the overall average for non-zero activity counts. (b) The same as (a) but for .
Yoshiharu Yamamoto (86101) +7 more
core +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source