Results 71 to 80 of about 1,603,529 (309)

Acute Cardiorespiratory Responses to Inspiratory Pressure Threshold Loading [PDF]

open access: yes, 2010
Purpose: We tested the acute responses to differing pressure threshold inspiratory loading intensities in well-trained rowers. The purpose of this study was to evaluate 1) how the magnitude of inspiratory pressure threshold loading influences repetition ...
Griffiths, L.A.   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

An Assessment of Indifference Threshold Values to Achieve Full Objective Indifference Threshold-Based Attribute Ratio Analysis

open access: yesMathematics
Multi-criteria decision-making (MCDM) models are moving toward being data-oriented. Meanwhile, MCDM models’ totalitarian reliance on experts’ preferences may reduce the accuracy of results in real-world challenges.
Sarfaraz Hashemkhani Zolfani   +1 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

About fertility: a constant value or changing values for the replacement threshold?

open access: yesStatistica, 2007
When we deal about fertility future evolution, it is generally believed – above all among people who do not deal with this topic – that in order to achieve an intrinsic rate of population natural increase equal to zero, able to ensure the constancy of ...
Luigi Di Comite, Teresa Traversa
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Hearing threshold values.

open access: yes, 2013
Mean hearing threshold values (+/− s.e.m., dB re 1 µPa) of the five size groups of L. cyclurus at each frequency tested. f = frequency; for exact size ranges see Materials and Methods.
Egon Heiss (305002)   +4 more
core   +1 more source

ON THE INFLUENCE OF STRATEGIC GAPS IN ECONOMY ON MANAGERIAL DECISIONS MAKING IN STATE MANAGEMENT

open access: yesRussian Journal of Economics and Law, 2011
The article presents the approaches towards investigating the interrelation between the analyses results of strategic gaps in social-economic development and determining the values of indicators-warnings of possible threats and risks of stability ...
N. Aksyonova
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

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