Results 51 to 60 of about 1,603,529 (309)

The relational threshold: a life that is valued, or a life of value? [PDF]

open access: yesJournal of Medical Ethics, 2019
The four thoughtful commentaries on our feature article draw out interesting empirical and normative questions. The aim of our study was to examine the views of a sample of the general public about a set of cases of disputed treatment for severely impaired infants.1 We compared those views with legal determinations that treatment was or was not in the ...
Dominic Wilkinson   +3 more
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Odour Detection Threshold Values for Fifty-two Selected Pure Compounds

open access: yesChemical Engineering Transactions, 2022
This paper provides updated odour detection threshold values (ODTV) for fifty-two (52) pure compounds. In 2014, the first updated odour threshold data (Bokowa, 2014) was presented for twenty-four (24) pure compounds.
Anna H. Bokowa
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Identification of a threshold to discriminate fasting hypertriglyceridemia with postprandial values

open access: yesLipids in Health and Disease, 2018
Background Postprandial lipemia is an important cardiovascular risk factor. The assessment of postprandial lipid metabolism is a newly trend that several consortiums and countries have adopted.
Magdalena del Rocío Sevilla-González   +11 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Foreign Economic Aspects of Ensuring Economic Security

open access: yesУправленческое консультирование
Foreign economic aspects of ensuring economic security are key in the modern world economy, which is determined by the processes of its internalization, globalization and regionalization. Foreign economic activity has a significant impact on the economic
A. A. Beda
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Threshold stochastic unit root models [PDF]

open access: yes, 2002
This paper introduces a new class of stochastic unit root (STUR) processes, where the randomness of the autorregresive unit root is driven by a threshold variable.
Gonzalo, Jesús, Montesinos, Raquel
core  

Multivariate contemporaneous threshold autoregressive models [PDF]

open access: yes
In this paper we propose a contemporaneous threshold multivariate smooth transition autoregressive (C-MSTAR) model in which the regime weights depend on the ex ante probabilities that latent regime-specific variables exceed certain threshold values.
Michael J. Dueker   +3 more
core   +2 more sources

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