Results 111 to 120 of about 1,711,818 (299)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
New Simple Procedure To Determine The Threshold Voltage Of Mosfets
, 2000 A new alternative technique is proposed to extract the threshold voltage from the subthreshold-to-strong inversion transition region of MOSFETs. It uses an auxiliary operator that involves integration of the drain current as a function of gate voltage ...
Ortiz-Conde, A. +8 more
core +2 more sources
, 2010 A method is proposed for determining the threshold voltage in a MOSFET, based on the derivative of the gm/Id ratio with respect to the gate voltage, which theoretically originates from the unified charge-control model similar to the capacitance ...
Kilchytska, Valeriya +5 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Self-Assembled Au Nanoelectrodes: Enabling Low-Threshold-Voltage HfO2‑Based Artificial Neurons
Filamentary-type resistive switching devices, such as conductive bridge random-access memory and valence change memory, have diverse applications in memory and neuromorphic computing.
Hongyi Dou (10144316) +11 more
core +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Voltage pulse generator for electroporation threshold evaluation
, 2016 Electrochemotherapy is a clinical therapy that uses voltage pulses to electropore cell membranes. This paper presents the description of an experimental set-up including the design of a prototype of voltage pulses generator for laboratory experiments in ...
F. Dughiero +23 more
core +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
A Fast and Accurate Process Variation-aware Modeling Technique for Resistive Bridge Defects
Recent research has shown that tests generated without taking process variation into account may lead to loss of test quality. At present there is no efficient device-level modeling technique that models the effect of process variation on resistive ...
Khursheed, Saqib +2 more
core +1 more source