Results 91 to 100 of about 1,445,591 (343)
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
A Threshold for Unsatisfiability
Journal of Computer and System Sciences, 1992 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Physics in Medicine and Biology, 1982 Interpretations of radiation effects frequently call upon the word 'threshold'. The authors explore the meaning of this word, its relationship to the fundamental character of radiation effects, and its influence on perception. Although the existence of either a dose or an LET threshold can never be settled by experimental radiobiological investigations,
Katz, Robert, Hofmann, Werner
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Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
IMAGE SEGMENTATION BY USING THRESHOLDING TECHNIQUES FOR MEDICAL IMAGES
, 2016 Image binarization is the process of separation of pixel values into two groups, black as background and white as foreground. Thresholding can be categorized into global thresholding and local thresholding.
Niblack Thresholding +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
A Comparative Study of Image Processing Techniques for Javanese Ancient Manuscripts Enhancement
IEEE AccessDigital preservation to preserve information in ancient manuscripts is often not optimal because of the object’s condition, which has degraded over time.
Imam Yuadi +3 more
doaj +1 more source
The Annals of Statistics, 2010 A new thresholding method, based on L-statistics and called order thresholding, is proposed as a technique for improving the power when testing against high-dimensional alternatives. The new method allows great flexibility in the choice of the threshold parameter. This results in improved power over the soft and hard thresholding methods.
Kim, Min Hee, Akritas, Michael G.
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