Results 141 to 150 of about 1,445,591 (343)

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

open access: yesMolecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo   +6 more
wiley   +1 more source

A Designed Thresholding Operator for Low-Rank Matrix Completion

open access: yesMathematics
In this paper, a new thresholding operator, namely, designed thresholding operator, is designed to recover the low-rank matrices. With the change of parameter in designed thresholding operator, the designed thresholding operator can apply less bias to ...
Angang Cui, Haizhen He, Hong Yang
doaj   +1 more source

Threshold cointegration and threshold dynamics

open access: yes, 2018
This study utilized monthly averages of daily rates for the 10-year constant maturity Treasury note, the Ibbotson Bond Index with maturity of 20-year Treasury Index, and Moody's Aaa and Baa seasoned bond indices to investigate the threshold behavior of interest rates pairs.
openaire   +4 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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