Results 51 to 60 of about 68,330 (260)

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Clinical characteristics of unknown symptom onset stroke patients with and without diffusion-weighted imaging and fluid-attenuated inversion recovery mismatch [PDF]

, 2017
Background: Diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) mismatch was suggested to identify stroke patients with unknown time of symptom onset likely to be within the time window for thrombolysis. Aims: We aimed
Boutitie, Florent, Cheng, Bastian, Cho, Tae-Hee, Ebinger, Martin, Endres, Matthias, Fiebach, Jochen B., Fiehler, Jens, Ford, Ian, Galinovic, Ivana, Gerloff, Christian, Lemmens, Robin, Muir, Keith W., Nighoghossian, Norbert, Pedraza, Salvador, Puig, Josep, Roy, Pascal, Simonsen, Claus Z., Thijs, Vincent, Thomalla, Götz   +18 more
core   +2 more sources

Efficacy and Safety of Intravenous Tenecteplase Before Endovascular Thrombectomy for Acute Ischemic Stroke: The Multicenter, Randomized, BRIDGE‐TNK Trial Protocol

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Six randomized trials have not detected a difference between intravenous alteplase plus endovascular thrombectomy and endovascular thrombectomy alone in stroke.
Zhongming Qiu, Fengli Li, Dongjing Xie, Guangxiong Yuan, Thanh N. Nguyen, Kai Zhou, Raul G. Nogueira, Jeffrey L. Saver, Bruce C.V. Campbell, Gregory W. Albers, Hongfei Sang, Linyu Li, Yan Tian, Zhaoyou Meng, Duolao Wang, Wenjie Zi, Qingwu Yang   +16 more
doaj   +1 more source

How a thrombectomy service can reduce hospital deficit: a cost-effectiveness study

Cost Effectiveness and Resource Allocation, 2022
Background There is level 1 evidence for cerebral thrombectomy with thrombolysis in acute large vessel occlusion. Many hospitals are now contemplating setting up this life-saving service.
Iris Q. Grunwald, Viola Wagner, Anna Podlasek, Gouri Koduri, Paul Guyler, Stephen Gerry, Sweni Shah, Horst Sievert, Aarti Sharma, Shrey Mathur, Klaus Fassbender, Kaveh Shariat, Graeme Houston, Avinash Kanodia, Silke Walter   +14 more
doaj   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Percutaneous thrombectomy of mural aortic thrombus using intravascular ultrasound guidance

Journal of Vascular Surgery Cases and Innovative Techniques, 2019
Mural aortic thrombus is a challenging clinical problem with significant potential complications. Particularly precarious are situations with involvement of the visceral segment of the aorta. We describe a technique for percutaneous thrombectomy of mural
Christopher D. Murter, MD, Abindra Sigdel, MD, Amit J. Dwivedi, MD, Erik J. Wayne, MD   +3 more
doaj   +1 more source

Abstract 218: Evaluating Thrombectomy Candidacy in Large Core Strokes: Lessons from the SELECT2 Trial at Our Institution

Stroke: Vascular and Interventional Neurology, 2023
Introduction Reperfusion therapy for patients with large vessel occlusion stroke includes thrombolytics and mechanical thrombectomy. Candidacy for thrombectomy depends on patient factors under active investigation.
Mohammad Khasawneh, Eve Moll, Brendan Eby, Laura Heitsch   +3 more
doaj   +1 more source

Endovascular Thrombectomy [PDF]

Stroke, 2018
Background and Purpose— This study aimed to explore safety of tirofiban in endovascular treatment of acute ischemic stroke. Methods— Two hundred eighteen ischemic stroke patients receiving endovascular ...
Wu, Yuefei, Yin, Congguo, Yang, Jianhong, Jiang, Lin, Parsons, Mark W., Lin, Longting   +5 more
openaire   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

No space Left for Intravenous thrombolysis in acute stroke [PDF]

, 2016
Recent successful clinical trials of endovascular thrombectomy for large artery ischaemic stroke have established the value of this treatment modality as an adjunct to intravenous thrombolysis, not as an alternative: thrombectomy delivery was undertaken ...
Muir, Keith
core   +1 more source