Results 101 to 110 of about 162,133 (299)

The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity

, 2000
The role of the platelet glycoprotein (GP) Ib-V-IX receptor in thrombin activation of platelets has remained controversial although good evidence suggests that blocking this receptor affects platelet responses to this agonist. The mechanism of expression
Dörmann, D, Kehrel, BE, Clemetson, KJ
core  

Patient‐Personalized Membrane‐Coated Magnetic Nanovectors: Probing the Biomimetic Interface for Targeted Tumor Theranostics

Advanced NanoBiomed Research, EarlyView.
This study presents a label‐free spectroscopic platform to evaluate membrane protein conformation on patient‐derived glioblastoma cell membrane‐coated magnetic nanovectors. This work demonstrates that preserving membrane protein integrity during nanoparticle fabrication enhances homotypic tumor targeting and reduces hard protein corona formation ...
Daniele De Pasquale, Michela Patrucco, Melike Belenli Gümüş, Alessandra Flori, Luca Menichetti, Stefania Moscato, Valentina Bonanni, Alessandra Gianoncelli, Milan Žižić, Pietro Fiaschi, Monica Truffelli, Andrea Bianconi, Melis Emanet, Gianmarco Ferri, Chiara Maria Mazzanti, Carlotta Pucci, Gianni Ciofani   +16 more
wiley   +1 more source

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIba.

, 2015
BACKGROUND: Platelets are essential for maintaining haemostasis and play a key role in the pathogenesis of cardiovascular disease. Upon ligation of platelet receptors through subendothelial matrix proteins, intracellular reactive oxygen species (ROS) are
E. Gardiner (23305693), Pat Metharom (23340427), J. Hamilton (1599490), J. Arthur (23305696), N. Carrim (23322985), R. Andrews (2731252), Michael Berndt (23285713), N. Moran (23401801)   +7 more
core  

Neurogenesis and apoptosis in the developmentally regulated loss of spinal cord regeneration. [PDF]

, 2006
Unlike the adult mammal, the chick can successfully regenerate its spinal cord until embryonic day (E) 13. Multiple factors may contribute to the subsequent loss of regenerative capacity, although most research has concentrated on axonal re-growth ...
Whalley, K.A., Whalley, Katherine Ann
core  

Clinical use of topical thrombin as a surgical hemostat

, 2008
Wesley K Lew1, Fred A Weaver21University of Southern California, Department of Surgery, Los Angeles, CA, USA; 2CardioVascular Thoracic Institute at the University of Southern California, Los Angeles, CA, USAAbstract: When surgical ligation of bleeding ...
Fred A Weaver, Wesley K Lew
core  

Modulation of thrombin and thrombin receptor peptide mitogenicity by human lung mast cell tryptase

, 1994
In previous studies, mast cell tryptase acted as a potent mitogen for fibroblasts from human lung and rodent embryonic tissue but failed to stimulate growth of cultured rat aortic vascular smooth muscle cells (VSMC).
G. H. Caughey, S. J. Ruoss, T. Hartmann
core   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

β-Adrenoceptor Agonists Attenuate Thrombin-Induced Impairment of Human Lung Endothelial Cell Barrier Function and Protect the Lung Vascular Barrier during Resuscitation from Hemorrhagic Shock

Biomedicines
β-adrenoceptor (β-AR) agonists are known to antagonize thrombin-induced impairment (TII) of bovine and ovine lung endothelial barrier function. The effects of adrenoceptor agonists and other vasoactive agents on human lung microvascular endothelial cell (
Michelle Y. McGee, Ololade Ogunsina, Sadia N. Boshra, Xianlong Gao, Matthias Majetschak   +4 more
doaj   +1 more source

Study on the modulating mechanism of human thrombomodulin on thrombin activated signaling

, 2009
[[abstract]]Thrombin, a multifunctional serine protease generated at sites of vascular injury, induces multiple phenotypic changes of blood and vascular cells to affect vascular tone, cell permeability and growth, and leukocyte trafficking.
tang chien hao
core  

Thrombin specificity assay.

, 2014
Wild type and engineered CBG were incubated with thrombin. Only CBG-antitrypsinPittsburgh and CBG-Thr349Arg were successfully cleaved by thrombin, while wild type CBG remained unreactive.
Randy J. Read (666315), Aiwu Zhou (666314), Wee Lee Chan (666313)   +2 more
core   +1 more source