Results 131 to 140 of about 162,133 (299)

Multimodal Imaging of Live Cells and Tumor Spheroids by a G‐Quadruplex DNA Selective Ru(II)Polypyridyl Probe

Chemistry – A European Journal, EarlyView.
Harnessing the light‑switch properties of Ru‑PDC3, we demonstrate that it binds to G‑quadruplex DNA within the nuclei of living cells where it can act as a probe for real‑time imaging or at higher concentrations/illumination it can act as photosensitizer inducing phototoxicity.
Karmel S. Gkika, Lorcan Holden, Giuseppe Avella, Rhianne C. Curley, Nirod K. Sarangi, Tia E. Keyes   +5 more
wiley   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Thrombin prevents the expression of inducible nitric oxide synthase in vascular smooth muscle cells by a proteolytically-activated thrombin receptor

, 1995
Proteolytically active forms of thrombin (α- and γ-thrombin) and thrombin receptor peptides inhibited the release of nitrite, a stable endproduct of nitric oxide, evoked by interleukin-1 β (IL-1 β) in cultured vascular smooth muscle cells while ...
Andersen, TT, Fenton Ii, JW, Vanhoutte, PM, Fisslthaler, B, Busse, R, SchiniKerth, VB   +5 more
core  

“Nature's Polymer Reimagined: Conventional and Green Routes to Pectin, Its Bioactive Promise and Industrial Applications”

Food Chemistry International, EarlyView.
Pectin, a versatile natural polymer, is extracted through conventional and emerging green extraction methods, offering multifunctional bioactive properties useful in food, pharmaceutical, and environmental applications. ABSTRACT Pectin, a molecular tapestry woven from diverse polysaccharides, holds a pivotal role across food, pharmaceutical, and ...
Afra Anika Rafique, Aunwesha Sahani, Md Morsaline Billah, Kazi Mohammed Didarul Islam   +3 more
wiley   +1 more source

COMPUTATIONAL STUDY FOR BINDING OF OSCILLARIN TO HUMAN alpha-THROMBIN

, 2009
Quantum mechanical calculation and molecular dynamics simulation have been carried out to study binding of Oscillarin (OSC), an antithrombotic marine natural product to human alpha-thrombin.
韩克利, Wu, Emilia L., Han, Keli, Zhang, John Z. H.   +3 more
core  

Recombinant activated factor VIIa for severe postpartum hemorrhage in Africa: Evidence, appropriate use, and research priorities—A narrative review

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Postpartum hemorrhage (PPH) accounts for 30%–50% of maternal mortality in Africa and occurs in the context of pre‐existing anemia, limited blood product availability, delayed recognition, and constrained referral systems. Although bundle‐based care (E‐MOTIVE), early tranexamic acid (TXA), and uterotonics have substantially improved outcomes, a
Johnny Mahlangu, Haroun Rhemtula, Jarrod Zamparini, Lawrence Chauke   +3 more
wiley   +1 more source

Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells

, 2013
G protein-coupled receptor signaling is mediated by three main mechanisms of action; these are the classical pathway, B-arrestin scaffold signaling, and the transactivation of protein-tyrosine kinase receptors such as those for EGF and PDGF. Recently, it
Micah Burch (20019435), M Febbraio (13279419), Peter Little AM (18043684), Robel Getachew (20019432), Narin Derrick (18031564)   +4 more
core  

Platelet‐Rich Fibrin (PRF) Application and Education in US Graduate Programs: A Cross‐Sectional Study

Journal of Dental Education, EarlyView.
ABSTRACT The aim of this cross‐sectional study was to assess platelet‐rich fibrin (PRF) application and education in clinical use among US graduate periodontology, endodontic, and oral and maxillofacial surgery programs. A survey questionnaire was electronically distributed to 84 oral and maxillofacial surgery (OMFS), 46 endodontic, and 46 ...
Elena Furman, Mark Piroutek, T. Roma Jasinevicius, Andre Paes B. da Silva   +3 more
wiley   +1 more source

Determinants of Early Renal Function Recovery After TIPS in Patients With Portal Hypertension

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Renal dysfunction frequently occurs in patients with portal hypertension and is linked to unfavorable clinical outcomes. Transjugular intrahepatic portosystemic shunt (TIPS) has the potential to enhance renal perfusion through portal decompression; however, factors predicting early improvement in renal function remain insufficiently defined ...
Meng Jia, Yang Luo, Zhao‐Yang Tan, Xiao‐Ling Zhou, Xi‐You Zhang, Jing‐Ying Sun, Ye Du   +6 more
wiley   +1 more source