Results 131 to 140 of about 145,978 (310)

Animal models of chronic thromboembolic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
Current animal models of CTEPH. Created using BioRender.com. Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, yet life‐threatening disorder characterized by persistent pulmonary vascular obstruction and elevated pulmonary artery pressure, with progressive remodeling and subsequent right heart failure.
Yong‐Jian Zhu, Lin‐Chao Zhou, Xiao‐Xue Zhang, Xiao‐Yang Ren, Yi Yan, Shao‐Fei Liu   +5 more
wiley   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Free-Energy Landscape of a Thrombin-Binding DNA Aptamer in Aqueous Environment

, 2012
Thrombin-bindingaptamer(TBA-15)isasingle-stranded15-meroligonucleotidethathasawiderangeof biomedicalapplications.Inthepresenceofmetalcationsofpropersizes,thisaptamerdisplaysG-quadruplexeswithasingle ...
김은애
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A mouse model of mechanical stress injury to the basal ganglia using thermosensitive PNIPAM hydrogel for intracerebral hemorrhage research

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a novel mouse model of intracerebral hemorrhage (ICH) by stereotactically injecting thermosensitive PNIPAM hydrogel into the internal capsule to impose localized mechanical stress on the corticospinal tract, which provides a straightforward and reproducible tool for preclinical studies on focal mechanical stress–induced ...
Mingxi Li, Yujie Chen, Rongsu Huang, Min Xia, Chao Mi, Yuan Tian, Peiwen Guo, Taotao Jin, Shilei Hao, Hua Feng, Yujie Chen, Zhi Chen   +11 more
wiley   +1 more source

Neurogenesis and apoptosis in the developmentally regulated loss of spinal cord regeneration.

, 2006
Unlike the adult mammal, the chick can successfully regenerate its spinal cord until embryonic day (E) 13. Multiple factors may contribute to the subsequent loss of regenerative capacity, although most research has concentrated on axonal re-growth ...
Whalley, K.A., Whalley, Katherine Ann
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Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood

Advanced NanoBiomed Research, EarlyView.
Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Anke Schmidt, Linus Hübner, Julia van der Linde   +5 more
wiley   +1 more source

Schematic of thrombin metrics.

, 2018
Three physiologically relevant metrics of Thrombin generation were calculated for sensitivity analysis: 1) lag time (Red), 2) maximum relative rate of thrombin generation, measured after 0.1nM of thrombin have been obtained (Green), and 3) final ...
Michael T. Stobb (5562881), Aaron L. Fogelson (483966), Karin Leiderman (483965), Suzanne S. Sindi (3332550), Kathryn G. Link (5562878), Jorge Di Paola (3181545), Keith B. Neeves (276368)   +6 more
core   +1 more source

Thrombin-induced platelet inhibition by 2′,4′-dihydroxychalcone and 2′,4′-dihydroxydihydrochalcone is mediated by inhibition of ROS production and Thromboxane synthase a activity: structure-activity relationship of polyphenol secondary metabolites from Empetrum nigrum

In this study, we expanded our previous work by testing compounds 1–12 for their ability to inhibit platelet activation at low (30 µM) concentration by inhibition of ROS production, thromboxane synthase (TxS) activity, and activation of cyclic nucleotide
Stepan Gambaryan (547351), Ekaterina Fock (18295888), Nikita Pronin (18295891), Anastasiia Whaley (18295894), Natalia Rukoyatkina (3369104), Andrei Whaley (18295897)   +5 more
core   +1 more source

Caracterización de la enzima similar a trombina del veneno de Bothrops pictus "jergón de costa

Revista Peruana de Medicina Experimental y Salud Pública
Objetivos. Realizar una caracterización bioquímica y molecular del principio coagulante del veneno de Bothrops pictus. Materiales y métodos. Se realizó la amplificación del gen a partir de cDNA, se analizó la homología de la secuencia nucleotídica y de ...
Dan Vivas-Ruiz, Gustavo A. Sandoval, Fanny Lazo, Edith Rodríguez, Armando Yarlequé, Eladio Flores-Sánchez   +5 more
doaj  

Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells

, 2013
G protein-coupled receptor signaling is mediated by three main mechanisms of action; these are the classical pathway, B-arrestin scaffold signaling, and the transactivation of protein-tyrosine kinase receptors such as those for EGF and PDGF. Recently, it
Micah Burch (20019435), M Febbraio (13279419), Peter Little AM (18043684), Robel Getachew (20019432), Narin Derrick (18031564)   +4 more
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