Results 211 to 220 of about 162,133 (299)

The XX Factor in Hemophilia: Diagnostic, Therapeutic, and Research Gaps for Women and Girls

Haemophilia, EarlyView.
ABSTRACT Introduction Hemophilia has traditionally been viewed as an X‐linked disorder affecting men and boys, with women and girls labeled as “carriers”, presumed to be clinically unaffected. This paradigm has contributed to under‐recognition, delayed diagnosis, and undertreatment of females with hemophilia‐associated genotypes despite an increasingly
Kelsey Uminski, Ellen Cusano
wiley   +1 more source

Beyond Rebalanced Haemostasis: Haemostatic Phenotypes, Thrombin Generation, and Clinical Risk in Chronic Liver Disease. [PDF]

TH Open
Agouba SM, Bradacova P, Mikler J, Drotarova M, Belakova KM, Brunclikova M, Voskova Gemelova V, Stasko J, Skornova I, Simurda T.   +9 more
europepmc   +1 more source

Population Pharmacokinetics of Plasma‑Derived Factor X Using Clotting and Chromogenic Assays: A WAPPS‑Hemo Model

Haemophilia, EarlyView.
ABSTRACT Background Hereditary factor X (FX) deficiency is a rare autosomal recessive bleeding disorder for which individualized pharmacokinetic (PK) assessment can support optimized prophylactic management. The WAPPS‐Hemo platform enables population pharmacokinetic (PopPK) individualized PK predictions based on sparse sampling.
Dagmar M. Hajducek, Pierre Chelle, Manuela Scarpellini, Andrea Edginton, Alfonso Iorio   +4 more
wiley   +1 more source

Correlation Between Von Willebrand Factor, Thrombin-Antithrombin Complex, and Disease Severity in Sickle Cell Disease: Implications for Thrombosis. [PDF]

J Blood Med
Onorhide AK, Nkarense OA, Banturaki A, Godwin U.   +3 more
europepmc   +1 more source

Perioperative Management in Persons With Haemophilia on Rebalancing Therapies: A Narrative Review

Haemophilia, EarlyView.
ABSTRACT Introduction Perioperative management in haemophilia often requires on‐demand use of clotting factor concentrates (CFC) and/or bypassing agents. Rebalancing agents (fitusiran, concizumab, marstacimab) offer a novel approach to prophylaxis by modulating endogenous anticoagulant pathways to restore haemostatic balance.
Amanda M. Henderson, Roy Khalife, Kelsey Uminski   +2 more
wiley   +1 more source

Mesoscale Simulations of Blood Coagulation in Flow and Quiescent Domains Using SDPD. [PDF]

Int J Numer Method Biomed Eng
Ferrero ME, Moreno N, Ellero M.
europepmc   +1 more source

Shared Decision‐Making in Haemophilia Involves More Treatment Differentiators in 2026

Haemophilia, EarlyView.
ABSTRACT Introduction Shared decision‐making regarding treatment choice in haemophilia care has become increasingly more complex and essential due to the availability of several innovative therapeutics that are characterized by their own advantages and limitations, which need to be tailored to individual patient needs.
Quentin Van Thillo, Guy Young, Cedric Hermans   +2 more
wiley   +1 more source

Senescent cardiac cells promote thrombus formation and impair fibrinolysis. [PDF]

Geroscience
Shahar T, Ezra N, Chen S, Kryukov O, Cohen S.   +4 more
europepmc   +1 more source

Coagulation Testing Practices and Guideline Adherence in Hemophilia A: A Retrospective Quality Assessment of a Dutch Expertise Hemophilia Treatment Center

Haemophilia, EarlyView.
Abstract Background Coagulation testing in persons with hemophilia A (PwHA) is required for diagnosis, monitoring replacement therapy, assessment of adherence, and detection of inhibitors. However, data on testing practices are limited, and alignment with guideline recommendations is unclear.
A. P. Bavinck, W. van Heerde, S. R. Rijpma, N. Blijlevens, S. E. M. Schols   +4 more
wiley   +1 more source

Antithrombin in Hyperuricemic Nephropathy: Unveiling Its Noncanonical Renoprotective Roles and Therapeutic Repurposing Potential.

Kidney Blood Press Res
Jin L, Zhang X, Wang F.
europepmc   +1 more source