Results 311 to 320 of about 249,410 (353)
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Blood Coagulation & Fibrinolysis, 2007
For intravenous anticoagulation, heparin has been the mainstay drug, but its use may be contraindicated in heparin-induced thrombocytopenia and thrombosis. Heparin alternatives including direct thrombin inhibitors are available, but clotting assays (e.g.
Taro, Taketomi +4 more
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For intravenous anticoagulation, heparin has been the mainstay drug, but its use may be contraindicated in heparin-induced thrombocytopenia and thrombosis. Heparin alternatives including direct thrombin inhibitors are available, but clotting assays (e.g.
Taro, Taketomi +4 more
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Trends in Cardiovascular Medicine, 1998
Thrombin plays both procoagulant and anticoagulant roles in the blood coagulation cascade. This dual role is influenced allosterically by the binding of Na(+) near the primary specificity pocket of the enzyme. Recent findings demonstrate that it is possible to engineer recombinant thrombins that have practically lost anticoagulant activity but retain ...
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Thrombin plays both procoagulant and anticoagulant roles in the blood coagulation cascade. This dual role is influenced allosterically by the binding of Na(+) near the primary specificity pocket of the enzyme. Recent findings demonstrate that it is possible to engineer recombinant thrombins that have practically lost anticoagulant activity but retain ...
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Chest, 2003
After generation from prothrombin, thrombin plays multiple roles in the blood coagulation cascade that are mediated by interaction with a number of physiologic substrates, effectors, and inhibitors. Structural and mutagenesis studies have helped unravel the molecular basis of thrombin interactions in the context of both well-established and emerging ...
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After generation from prothrombin, thrombin plays multiple roles in the blood coagulation cascade that are mediated by interaction with a number of physiologic substrates, effectors, and inhibitors. Structural and mutagenesis studies have helped unravel the molecular basis of thrombin interactions in the context of both well-established and emerging ...
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Chest, 2003
The generation of the enzyme thrombin from its precursor prothrombin is the central event of the blood coagulation process, which is essential to hemostasis and the culprit in thrombosis. Thrombin is produced by a complex series of proteolytic events that are initiated when cryptic tissue factor interacts with plasma factor VIIa to initiate the complex
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The generation of the enzyme thrombin from its precursor prothrombin is the central event of the blood coagulation process, which is essential to hemostasis and the culprit in thrombosis. Thrombin is produced by a complex series of proteolytic events that are initiated when cryptic tissue factor interacts with plasma factor VIIa to initiate the complex
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Thrombin-soaked Coils: Estimation of Thrombin Dose
Journal of Vascular and Interventional Radiology, 1991Thrombin-soaked coils have been used as embolic agents for the treatment of various conditions. Intravascular injection of thrombin also has been used for thrombus formation; however, the effects of high doses of intravascular thrombin may be detrimental.
J T, Harman, G J, Becker
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012
Thrombin is the final protease generated in the blood coagulation cascade. It has multiple substrates and cofactors, and serves both pro- and anti-coagulant functions. How thrombin activity is directed throughout the evolution of a clot and the role of conformational change in determining thrombin specificity are issues that lie at the heart of the ...
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Thrombin is the final protease generated in the blood coagulation cascade. It has multiple substrates and cofactors, and serves both pro- and anti-coagulant functions. How thrombin activity is directed throughout the evolution of a clot and the role of conformational change in determining thrombin specificity are issues that lie at the heart of the ...
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Canadian Journal of Biochemistry and Physiology, 1957
The enzymatic properties of thrombin have been examined and compared with those of two related enzymes, plasmin and trypsin. The effects of factors such as pH, substrate specificity, ionic strength, cations, anions, and organic reagents on the enzymatic activity of thrombin have been studied. While the three enzymes discussed possess differences, such
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The enzymatic properties of thrombin have been examined and compared with those of two related enzymes, plasmin and trypsin. The effects of factors such as pH, substrate specificity, ionic strength, cations, anions, and organic reagents on the enzymatic activity of thrombin have been studied. While the three enzymes discussed possess differences, such
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Thrombin and Thrombin Inhibitors
1998Thrombin is a 37 kDa glycosylated trypsin-like serine protease that has multiple biological functions. It is formed from a precursor protein, the zymogen prothrombin, by a complex of Factor Xa, Va, phospholipid, and calcium (Tracy et al., 1981). Prothrombin is synthesized by the liver and secreted into the blood stream (Fenton, 1986), where it is ...
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Neurology, 2004
Not so long ago, events altering neurologic function were classified as “spells,” underscoring their cryptic nature. In time, many of these events were found to be ischemic strokes. That cerebral ischemia can be accompanied by alterations in the plasma is the basis for the hunt for convenient markers of brain injury that may suggest the cause.
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Not so long ago, events altering neurologic function were classified as “spells,” underscoring their cryptic nature. In time, many of these events were found to be ischemic strokes. That cerebral ischemia can be accompanied by alterations in the plasma is the basis for the hunt for convenient markers of brain injury that may suggest the cause.
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The international journal of biochemistry & cell biology, 1998
Thrombin is a multifunctional serine protease which plays a central role in haemostasis by regulating platelet aggregation and blood coagulation. It is formed from its precursor prothrombin following tissue injury and converts fibrinogen to fibrin in the final step of the clotting cascade. It also promotes numerous cellular effects including chemotaxis,
N R, Goldsack +3 more
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Thrombin is a multifunctional serine protease which plays a central role in haemostasis by regulating platelet aggregation and blood coagulation. It is formed from its precursor prothrombin following tissue injury and converts fibrinogen to fibrin in the final step of the clotting cascade. It also promotes numerous cellular effects including chemotaxis,
N R, Goldsack +3 more
openaire +1 more source