Results 161 to 170 of about 22,958 (212)
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Seminars in Hematology, 2005
Significant progress in our understanding of the molecular pathogenesis of essential thrombocythemia (ET) and the other Philadelphia (Ph) chromosome-negative myeloproliferative disorders (MPDs) has recently been achieved. Unfortunately, the diagnosis of ET still relies on a set of exclusion criteria developed years ago, as recent advances have yet to ...
Guido, Finazzi, Claire, Harrison
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Significant progress in our understanding of the molecular pathogenesis of essential thrombocythemia (ET) and the other Philadelphia (Ph) chromosome-negative myeloproliferative disorders (MPDs) has recently been achieved. Unfortunately, the diagnosis of ET still relies on a set of exclusion criteria developed years ago, as recent advances have yet to ...
Guido, Finazzi, Claire, Harrison
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Thrombocytosis and Thrombocythemia
Hematology/Oncology Clinics of North America, 1990Elevated platelet counts may be encountered as a reactive phenomenon secondary to a variety of systemic conditions (thrombocytosis) or may represent a primary disorder of the bone marrow (thrombocythemia). The diagnosis of essential thrombocythemia is difficult and relies on exclusion of other myeloproliferative states and nonhematologic illnesses ...
A J, Mitus, A I, Schafer
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Thrombocytosis and thrombocythemia
Blood Reviews, 2001Thrombocytosis is caused by three major pathophysiological mechanisms: (1) reactive or secondary thrombocytosis; (2) familial thrombocytosis; and (3) clonal thrombocytosis, including essential thrombocythemia and related myeloproliferative disorders.
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Current Opinion in Hematology, 1996
The pathogenesis of essential thrombocythemia as a clonal myeloproliferative disorder has been clearly established. However, there continues to be considerable controversy concerning the management of this disease, particularly because its natural history is consistent with a nearly normal life expectancy. Therapeutic decisions have been complicated by
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The pathogenesis of essential thrombocythemia as a clonal myeloproliferative disorder has been clearly established. However, there continues to be considerable controversy concerning the management of this disease, particularly because its natural history is consistent with a nearly normal life expectancy. Therapeutic decisions have been complicated by
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Management of Essential Thrombocythemia
Critical Reviews in Oncology/Hematology, 19993. Risk stratification of patients with ET . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 258 3.1. Bleeding and thrombosis in ET . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 258 3.2. Risk factors for major bleeding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259 3.3. Risk factors for thrombosis. .
T, Barbui, G, Finazzi
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Annals of Internal Medicine, 1978
Excerpt To the editor: The recent article by Dr. Wu (Ann Intern Med88:7-11, 1978) adds valuable data to the study of platelet disorders in patients with myeloproliferative diseases.
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Excerpt To the editor: The recent article by Dr. Wu (Ann Intern Med88:7-11, 1978) adds valuable data to the study of platelet disorders in patients with myeloproliferative diseases.
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Pharmacotherapy of essential thrombocythemia
Expert Opinion on Pharmacotherapy, 2008The natural history of essential thrombocythemia is characterized by an increased incidence of thrombotic and hemorrhagic events and, in the long-term, a tendency for disease transformation to myelofibrosis or acute leukemia. Advanced age and a prior history of thrombosis are the major predictors of thrombotic complications.The aim of this study was to
Naseema, Gangat, Ayalew, Tefferi
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Primary hemorrhagic thrombocythemia
The American Journal of Medicine, 1960Abstract 1.1. Six new cases of primary hemorrhagic thrombocythemia are reported. All six patients exhibited thrombohemorrhagic phenomena in one form or another. Purpura, epistaxis, and bleeding of the gums and gastrointestinal tract were common. All had hepatosplenomegaly.
F L, OZER +3 more
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Essential Thrombocythemia in Childhood
Seminars in Thrombosis and Hemostasis, 1997In addition to the criteria of the Polycythemia Vera Study Group, positive markers for essential thrombocythemia (ET) include spontaneous BFU-E, splenomegaly, and megakaryocyte morphology in bone marrow smears and biopsy material. The hematologic features of 11 reported cases of ET in childhood showed platelet counts in excess of 1000 x 10(9)/L in all,
J J, Michiels, P J, Van Genderen
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JAMA
ImportanceEssential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis and bleeding. The annual incidence rate of essential thrombocythemia in the US is 1.5/100 000 persons.ObservationsPatients with essential thrombocythemia have a persistent platelet count of 450
Ayalew, Tefferi +8 more
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ImportanceEssential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis and bleeding. The annual incidence rate of essential thrombocythemia in the US is 1.5/100 000 persons.ObservationsPatients with essential thrombocythemia have a persistent platelet count of 450
Ayalew, Tefferi +8 more
openaire +2 more sources