Results 31 to 40 of about 145,313 (292)
Advanced Science, EarlyView.This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen +10 more
wiley +1 more source
Antioxidants, 2023 The antioxidative proteolytic fraction, MA-1, was partially purified from Mycoleptodonoides aitchisonii. MA-1 was purified to homogeneity using a two-step procedure, which resulted in an 89-fold increase in specific activity and 42.5% recovery.
Sung-Ho Lee +8 more
doaj +1 more source
Advanced Science, EarlyView.Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong +22 more
wiley +1 more source
Thromboembolism after Astra Zeneca COVID-19 vaccine: Not always PF4- antibody mediated
Human Vaccines & Immunotherapeutics, 2023 Cases of thromboembolic events in 2021 flared up the discussion about the safety of Astra Zeneca’s AZD1222 vaccine. We hereby report three cases of pulmonary embolism (PE), one case of extended portal vein thrombosis, and one case of combined portal vein
Sascha d’Almeida +11 more
doaj +1 more source
Impact of Combined Resection of the Pancreas on Long‐Term Survival in Gastric Cancer
Annals of Gastroenterological Surgery, EarlyView.Short‐term and long‐term results of patients underwent conbined pancreatectomy was investigated in 64 patients with gastric cancer. R1 resection and postoperative intraabdominal infectious complications were identified as independent prognostic factors.
Taku Hattori +8 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.This single‐center retrospective study evaluated perioperative outcomes after hepatectomy in 749 patients, including 140 receiving ATT, using propensity score matching to compare ATT and non‐ATT cohorts. Under standardized perioperative management, ATT did not increase major bleeding, transfusion, or severe morbidity overall; however, within the ATT ...
Haruki Mori +9 more
wiley +1 more source
The Oncologist, EarlyView., 2021 Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi +21 more
wiley +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Postpartum hemorrhage (PPH) remains the leading cause of preventable maternal mortality despite standard interventions. Recent fibrinogen trials failed to improve outcomes, prompting interest in coagulation factor XIII (FXIII). FXIII functions as “molecular cement,” cross‐linking fibrin and stabilizing clots.
Jeremy W. Jacobs +8 more
wiley +1 more source
Coagulation and thrombotic risk in thalassemia intermedia
Thalassemia Reports, 2011 As the life expectancy of β-thalassemia patients has markedly improved over the last few decades, several manifestations are increasingly recognized.
A.T. Taher, K.M. Musallam
doaj +1 more source
Swedish obstetric thromboprophylaxis guideline: background and update
Journal of Obstetrics and Gynaecology, 2023 Risk estimation concerning venous thromboembolism (VTE) and thromboprophylaxis for those at risk is routine in pregnancy. For 20 years, Swedish obstetricians have followed a weighted-risk algorithm guideline for risk estimation, based on which patient ...
Pelle G. Lindqvist +2 more
doaj +1 more source