Results 81 to 90 of about 3,493 (156)

Supernatants from stored platelet concentrates modulate the inflammatory response in platelet-depleted blood ex vivo

Frontiers in Immunology
IntroductionPlatelets contain a wide range of bioactive mediators, many of which accumulate during storage of platelet concentrates and have immunomodulatory properties.
Linnea I. Andersson, Linnea I. Andersson, Dick J. Sjöström, Dick J. Sjöström, Nahreen Tynngård, Nahreen Tynngård, Camilla Mohlin, Camilla Mohlin, Huy Quang Quach, Ivar Tjernberg, Ivar Tjernberg, Sofia Ramström, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson   +15 more
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Fetal systemic inflammatory response syndrome, thromboinflammation and neonatal septic shock: pathogenesis, diagnostics and treatment

Акушерство, гинекология и репродукция
The article is dedicated to outlining the pathogenic mechanisms, diagnostic criteria, and treatment of systemic inflammatory response syndrome (SIRS), thromboinflammation, and septic shock in fetuses and newborns. SIRS is a body hyperreaction to external
V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, N. A. Makatsariya, R. I. Gabidullina, A. V. Mostovoi, A. L. Karpova, A. E. Voynovskiy, M. G. Novosartyan, A. V. Lazarchuk, A. R. Khisamieva, A. Yu. Tatarintseva, A. V. Vorobev, K. V. Agasyan, D. L. Kapanadze, M. S. Zainulina, V. N. Serov, D. V. Blinov, Jean-Christophe Gris, P. Van Dreden, I. Elalamy, G. Gerotziafas, A. D. Makatsariya   +22 more
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Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration

The cardiovascular and renovascular complications of metabolic deterioration are associated with localized adipose tissue dysfunction. We have previously demonstrated that metabolic impairment delineated the heightened vulnerability of both the ...
Mougharbil, Nahed, Arab, Ghida Al, El-Yazbi, Ahmed F., Abdalla, Samaya, Eid, Ali H., Al-Saidi, Aya, Alzaim, Ibrahim F., Hammoud, Safaa H.   +7 more
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Fibrin drives thromboinflammation and neuropathology in COVID-19 [PDF]

Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection1–4.
Red-Horse, Kristy, Bouhaddou, Mehdi, Ott, Melanie, Helmy, Ekram, Shin, Min-Gyoung, Arun, Nikhita, Alzamora, Maria del Pilar S, Rios Coronado, Pamela E, Tognatta, Reshmi, Thomas, Reuben, Meyer-Franke, Anke, Matsui, Yusuke, Liu, Yixin, Kouznetsova, Valentina L, Trevino, Troy N, Petersen, Mark A, Ellisman, Mark H, Kaushal, Prashant, Makanani, Sara K, Deerinck, Thomas J, Agrawal, Ayushi, Montano, Mauricio, Suryawanshi, Rahul K, Akassoglou, Katerina, Schuck, Renaud, Meza Acevedo, Rosa, Aries, Oliver, Le, Lucas, Miyajima, Hisao, MacDonald, Eilidh, Sozmen, Elif G, Guo, Brandon, Tsigelny, Igor F, Weaver, Olivia, Greene, Warner C, Yan, Aaron, Mendiola, Andrew S, Taha, Taha Y, Krogan, Nevan J, Ryu, Jae Kyu, Yan, Zhaoqi, Traglia, Michela, Pico, Alexander R, Dixit, Karuna   +43 more
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Development and Validation of the CARRA-VID Prognostic Score: C Reactive Protein to Albumin Ratio, Red Blood Cell Distribution Width and Age-Based Score for Prognostication of Hospitalized COVID-19 Patients

Viruses
Patients hospitalized due to coronavirus disease 2019 (COVID-19) usually present with severe or critical intensity of symptoms, accompanied by a marked systemic inflammatory response.
Marko Lucijanic, Nevenka Piskac Zivkovic, Nikolina Busic, Josip Stojic, Armin Atic, Lovorka Derek, Ivan Krecak, Bruno Barsic, Ivica Luksic   +8 more
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Mechanisms of Thromboinflammation in Viral Infections—A Narrative Review

Viruses
The circulatory and immune systems function in close coordination to maintain homeostasis and act as a frontline defense against infections. However, under certain conditions, this interaction becomes dysregulated, leading to thromboinflammation, a ...
Viviane Lima Batista, Jenniffer Ramos Martins, Celso Martins Queiroz-Junior, Eugenio Damaceno Hottz, Mauro Martins Teixeira, Vivian Vasconcelos Costa   +5 more
doaj   +1 more source

Evaluation of the podoplanin/C-type lectin-like receptor-2 (CLEC-2) pathway as a mediator of platelet and coagulation activation in sickle cell disease

Research and Practice in Thrombosis and Haemostasis
Background: Sickle cell disease (SCD) is a condition characterized by a prothrombotic state attributed to the simultaneous activation of hemostasis and innate immunity, referred to as thromboinflammation.
Ivanio Teixeira Borba-Junior, Mayck da Silva Barbosa, Carla Roberta Peachazepi Moraes, Letícia Queiroz Silva, Irene Santos, Bruno Benites, Joyce M. Annichino-Bizzacchi, Fernando Ferreira Costa, Erich Vinicius De Paula   +8 more
doaj   +1 more source

Platelets-driven monocyte activation promotes hypoxic thromboinflammation through the HIF-1α-NLRP3-EGR-1 axis [PDF]

Hypoxia exacerbates thromboembolism and sterile inflammation through NLRP3 inflammasome, which is directly activated by HIF-1α that plays a pivotal role in potentiating deep vein thrombosis (DVT). One of the clinical manifestations of thromboinflammation
Kashika Singh, Mohammad Zahid Ashraf, Syed Mohd, Tathagata Chatterjee, Tashi Thinlas, Sayeed Ahmad, Shankar Chanchal, Raishal Safdar   +7 more
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Innovative approaches to assessing risk factors, diagnostics and treatment of neonatal thrombosis

Акушерство, гинекология и репродукция
Compared to children of other ages, neonates especially seriously ill and premature subjects comprise a high thrombotic risk group. A decline in the incidence of neonatal thrombosis may be accounted for by improved treatment of severe conditions in ...
A. D. Makatsariya, A. V. Vorobev, A. V. Lazarchuk, S. E. Einullaeva, N. A. Gomenko, F. A. Magomedova, V. O. Bitsadze, J. Kh. Khizroeva, N. A. Makatsariya, V. B. Zubenko, M. V. Tretyakova, D. V. Blinov, F. E. Yagubova, N. R. Gashimova, K. N. Grigoreva, M. A. Ponimanskaya, O. N. Li, A. V. Mostovoi, A. L. Karpova, J-C. Gris, I. Elalamy   +20 more
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TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice: Brief Report

, 2016
Objective-It is known that both platelets and coagulation strongly influence infarct progression after ischemic stroke, but the mechanisms and their interplay are unknown.
Wanitchakool, Podchanart, Kunzelmann, Karl, Kleinschnitz, Christoph, Swieringa, Frauke, Stegner, David, Geuss, Eva, Heemskerk, Johan W. M., Baig, Ayesha A., Nieswandt, Bernhard, Schuhmann, Michael K., Braun, Attila, Beck, Sarah, Haining, Elizabeth J.   +12 more
core   +1 more source