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Inherited Thrombophilia

Journal of Pharmacy Practice, 2014
Thrombophilia alters normal hemostasis, shifting the balance in favor of thrombus formation. Inherited conditions include factor V Leiden (FVL), prothrombin G20210A mutation, deficiencies in natural anticoagulants (antithrombin [AT], protein C, and protein S), hyperhomocysteinemia, and elevations in clotting factors (factors VIII and XI).
Haley M, Phillippe   +4 more
openaire   +2 more sources

Thrombophilia in Cancer

Seminars in Thrombosis and Hemostasis, 2005
Malignancy is an acquired thrombophilic condition associated with a significant risk of thrombosis. Venous and arterial thromboembolism is a common complication for patients with cancer, who also present with a hypercoagulable state, even in the absence of manifest thrombosis. Furthermore, clotting activation may play a role in tumor progression.
openaire   +2 more sources

Acquired Thrombophilia

Journal of Pharmacy Practice, 2014
Acquired thrombophilia is associated with an increased risk of venous thromboembolism (VTE). Antiphospholipid syndrome (APS) is the most prevalent acquired thrombophilia and is associated with both venous and arterial thromboses. Human immunodeficiency virus (HIV) is another form of acquired thrombophilia.
Lori B Hornsby, Sarah Treadway
exaly   +3 more sources

Inherited Thrombophilia

Critical Reviews in Clinical Laboratory Sciences, 2006
Inherited thrombophilia can be defined as a genetically determined predisposition to the development of thromboembolic complications. Since the discovery of activated protein C resistance in 1993, several additional disorders have been described and, at present, it is possible to identify an inherited predisposition in about 60 to 70% of patients with ...
Franchini M.   +4 more
openaire   +3 more sources

Contraception and thrombophilia

Hämostaseologie, 2009
SummaryThe risk of thromboembolic events (TE) is increased by acquired or inherited thrombo -philias (IT). We know that some hormonal contraceptives also increase the risk of thrombosis, thus, the use of such contraceptives are discussed as contraindications in women with IT.
H, Rott   +4 more
openaire   +2 more sources

Hyperhomocysteinemia and thrombophilia

Clinical Chemistry and Laboratory Medicine, 2010
It is now widely accepted that hyperhomocysteinemia (HHC) is a risk factor for thrombophilia. HHC is the result of either impaired enzyme function or a deficiency of vitamin B (folate, B₆, B₁₂), or both, and can be treated with vitamin supplements.
openaire   +2 more sources

Thrombophilia in childhood

Current Problems in Pediatric and Adolescent Health Care, 2004
Much progress has been made in the understanding of pediatric thrombophilia in the last decade, but many unanswered questions still exist. The incidence of thrombophilia in childhood, though low, may be on the rise because of increases in the occurrence of acquired risk factors and increased detection resulting from improved imaging techniques. In this
Deepa, Bhojwani, David, Hart
openaire   +2 more sources

Thrombophilia

2021
This chapters defines thrombophilia, looks at the causes, and discusses the methods used to identify the defects that may be involved. It explains that the term thrombophilia literally translates to ‘clot-loving’, which is caused by defects or deficiencies of the anticoagulant system that lead to a predisposition to thrombosis.
Gary Moore, Ian Jennings
openaire   +1 more source

Thrombophilia and Stroke

Topics in Stroke Rehabilitation, 2003
Thrombophilia is defined as an enhanced tendency to form intravascular thrombi, which may be arterial or venous. Of the inherited thrombophilias, factor V Leiden and the prothrombin 20210 mutation have been associated with stroke, but this association is statistically significant only in children and adults under age 40.
openaire   +2 more sources

Oral Contraception and Thrombophilia

Postgraduate Obstetrics & Gynecology, 2007
To describe current knowledge related to the association between oral contraception and the thrombophilias.The use of oral contraception increases the risk of venous thromboembolism as well as arterial thrombosis. Third-generation pills seem to increase the risk of venous thromboembolism compared with second-generation pills.
Dorit, Blickstein, Isaac, Blickstein
openaire   +2 more sources

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