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Biologicals, 2010
The Prothrombin Time (PT) test is used for monitoring of treatment with Vitamin K-antagonists (VKA). The result of the PT test should be expressed as the International Normalized Ratio (INR). Calculation of INR is based on the availability of International Standards (IS) for thromboplastin and a calibration model. Calibration of a new PT test system is
A. M. van den Besselaar +2 more
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The Prothrombin Time (PT) test is used for monitoring of treatment with Vitamin K-antagonists (VKA). The result of the PT test should be expressed as the International Normalized Ratio (INR). Calculation of INR is based on the availability of International Standards (IS) for thromboplastin and a calibration model. Calibration of a new PT test system is
A. M. van den Besselaar +2 more
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The Inactivation of Plasma-Thromboplastin
Thrombosis and Haemostasis, 1958Summary1. Anti-plasmathromboplastin activity is found in plasma and in serum.2. The anti-plasmathromboplastin activity was increased in the majority of patients with hemophilia A and B, with chronic idiopathic thrombocytopenia, uremia, and in the cases of obstetrical afibrinogenemia, obstructive jaundice and Morbus Addison examined.
Deutsch E, Mammen E
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Calibration of thromboplastins
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1995Anticoagulant therapy with coumarin drugs requires tests on the patient's blood to determine the dose rate for the drug. The tests involve measuring the effect of a preparation of a certain reagent, thromboplastin, in accelerating the clotting of the patient's blood.
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Thrombosis and Haemostasis, 1970
SummaryTissue thromboplastin is the key reagent in the one-stage prothrombin time test. To obtain reliable results, a potent thromboplastin with constant activity and stability is required. This need is met by acetone-dehydrated rabbit brain. This reagent, when protected against oxidation by sealing in an evacuated tube, retains its full activity ...
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SummaryTissue thromboplastin is the key reagent in the one-stage prothrombin time test. To obtain reliable results, a potent thromboplastin with constant activity and stability is required. This need is met by acetone-dehydrated rabbit brain. This reagent, when protected against oxidation by sealing in an evacuated tube, retains its full activity ...
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Thromboplastin generation by saliva
Oral Surgery, Oral Medicine, Oral Pathology, 1962Abstract In order to determine directly whether saliva has any specific thromboplastic activity or whether its effect in accelerating blood coagulation is nonspecific, we compared saliva with commercial tissue thromboplastins in the following modified hematologic tests: 1. 1.
Richard G. Taylor, H.Chris Doku
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The thermolability of tissue thromboplastins
Irish Journal of Medical Science, 19661. The thermolability of tissue thromboplastins is markedly increased in the presence of cysteine, glutathione sulphite and hydrosulphite, but not in the presence of cysteine, ascorbate, thiosulphate or thiocyanate. 2. Thermostability is increased by fluoride (and ageing), but is overcome by cysteine. 3.
R. A. Q. O’Meara, W. A. Boggust
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1984
A few years ago, a field trial was carried out in which a large number of plasma samples (100 normals, 806 anticoagulated patients, as well as patients with deficiencies of the factors II, V, VII and X) were tested with a newly developed rabbit brain thromboplastin (Thromboplastin FS) and with Human Brain Thromboplastin prepared by Prof.
R. Spaethe, I. Shirley
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A few years ago, a field trial was carried out in which a large number of plasma samples (100 normals, 806 anticoagulated patients, as well as patients with deficiencies of the factors II, V, VII and X) were tested with a newly developed rabbit brain thromboplastin (Thromboplastin FS) and with Human Brain Thromboplastin prepared by Prof.
R. Spaethe, I. Shirley
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Pediatrics, 1956
Infants less than 6 months of age have decreased thromboplastin generation, resulting in part from a deficiency of plasma thromboplastin component. Some factor or factors other than a low level of plasma thromboplastin component may contribute to this deficiency.
Arthur E. McElfresh +2 more
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Infants less than 6 months of age have decreased thromboplastin generation, resulting in part from a deficiency of plasma thromboplastin component. Some factor or factors other than a low level of plasma thromboplastin component may contribute to this deficiency.
Arthur E. McElfresh +2 more
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THROMBOPLASTIN REFERENCE PREPARATIONS
Scandinavian Journal of Haematology, 1980The need for standardization of methods for the control of anticoagulant therapy was apparent 25 years ago. With the development of the ratio method for comparing the sensitivity of different thromboplastin preparations it became possible to equate the value obtained with one preparation in terms of the value which would be obtained with any other ...
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Thromboplastin Generation Test
JAMA: The Journal of the American Medical Association, 1967In the classical theory of blood coagulation, it was postulated that prothrombin was converted to thrombin through the action of calcium and thromboplastin. It is now established that circulating blood contains no active thromboplastin but that thromboplastin is generated during coagulation.
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