Results 91 to 100 of about 7,460 (217)

Utility and Safety of Romiplostim in Pediatric Allogeneic Stem Cell Transplantation

Pediatric Transplantation, Volume 29, Issue 8, December 2025.
ABSTRACT Background The use of romiplostim, a thrombopoietin agonist, has increased in the last decade for the treatment of immune mediated thrombocytopenia and severe aplastic anemia. Its utility has been explored in the management of delayed platelet engraftment and secondary platelet failure during stem cell transplant (SCT), but its use has ...
Srividhya Senthil, Abdul Moothedath, Jane Elizabeth Potter, Heather Mcgrath Wilkinson, Eden Whiteside, Ramya Nataraj, Omima Mustafa, Claire Horgan, Denise Bonney, Sarah Brett, Rob Wynn   +10 more
wiley   +1 more source

Regulating mitochondrial oxidative phosphorylation and MAPK signaling: wedelolactone as a novel therapeutic for radiation-induced thrombocytopenia

Frontiers in Pharmacology
IntroductionRadiation-induced thrombocytopenia (RIT) is a serious complication of cancer radiotherapy, for which therapeutic options are limited. This study investigates wedelolactone (WED), a metabolite of a botanical drug, as a potential treatment for ...
Zhichao Li, Qinyao Li, Shuang Wu, Xinyue Mei, Xiao Qi, Sheng Liu, Gan Qiao, Hongping Shen, Jiesi Luo, Jing Zeng, Feihong Huang, Rong Li, Rong Li, Long Wang   +13 more
doaj   +1 more source

A Rare Hematopoietic Stem Cell‐Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging

Aging Cell, Volume 24, Issue 11, November 2025.
Manso et al. developed strategies for isolating and testing the functional mechanisms regulating age‐specific megakaryocyte progenitors derived from hematopoietic stem cells. ABSTRACT Distinct routes of cellular production from hematopoietic stem cells (HSCs) have defined our current view of hematopoiesis.
Bryce A. Manso, Paloma Medina, Stephanie Smith‐Berdan, Alessandra Rodriguez y Baena, Elmira Bachinsky, Lydia Mok, Angela Deguzman, Sarah Beth Avila, Connor Van Voorhis, Saran Chattopadhyaya, Marcel G. E. Rommel, Jenna Myers, Vanessa D. Jönsson, E. Camilla Forsberg   +13 more
wiley   +1 more source

Physiologic Role of TPO in Thrombopoiesis [PDF]

Stem Cells, 1996
Recombinant human thrombopoietin (rHuTPO) serves as a megakaryocyte colony-stimulating factor and predominantly acts on GPIIb/IIIa+ rat late megakaryocyte progenitor cells, colony forming units-megakaryocyte (CFU-MK). The GPIIb/IIIa+ fraction of CFU-MK differentiates into mature megakaryocytes and further into proplatelets in liquid culture containing ...
openaire   +2 more sources

Prolonged Thrombocytopenia in a Child with Severe Neonatal Alloimmune Reaction and Noonan Syndrome [PDF]

, 2015
Fetomaternal alloimmune thrombocytopenia (FMAIT) caused by maternal antibodies is the leading cause of severe neonatal thrombocytopenia. A 1-month-old Caucasian girl was referred to our Hematology Clinic for persistent thrombocytopenia diagnosed after a ...
Batalha, S, Kjollerstrom, P, Maia, R, Salva, I   +3 more
core   +1 more source

Prognostic Role of Platelets in Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 15, Issue 4, October 2025.
ABSTRACT Platelets have emerged as immune‐inflammatory cells that may contribute to the pathogenesis and prognosis of pulmonary arterial hypertension (PAH), although their clinical relevance remains uncertain. We retrospectively evaluated platelet indices in 243 patients with PAH from a tertiary referral center and compared them with 50 normopressoric ...
Caio Julio Cesar dos Santos Fernandes, Ilma Alves de Oliveira Nascimento, Talita Oliveira, Carlos Vianna Poyares Jardim, Susana Hoette, Rogerio de Souza   +5 more
wiley   +1 more source

Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis

Platelets, 2017
Autophagy is an effective strategy for cell development by recycling cytoplasmic constituents. Genetic deletion of autophagy mediator Atg7 in hematopoietic stem cells (HSCs) can lead to failure of megakaryopoiesis and enhanced autophagy has been ...
Qi Wang, Tao You, Hongqiong Fan, Yinyan Wang, Tinatian Chu, Mortimer Poncz, Li Zhu   +6 more
doaj   +1 more source

The molecular mechanisms that control thrombopoiesis [PDF]

Journal of Clinical Investigation, 2005
Our understanding of thrombopoiesis--the formation of blood platelets--has improved greatly in the last decade, with the cloning and characterization of thrombopoietin, the primary regulator of this process. Thrombopoietin affects nearly all aspects of platelet production, from self-renewal and expansion of HSCs, through stimulation of the ...
openaire   +2 more sources

The efficacy of recombinant thrombopoietin in murine and nonhuman primate models for radiation-induced myelosuppression and stem cell transplantation [PDF]

, 1998
Radiation-induced pancytopenia proved to be a suitable model system in mice and rhesus monkeys for studying thrombopoietin (TPO) target cell range and efficacy.
Eaton, D.L., Fielder, P.J., Hartong, S.C.C. (Simone), Neelis, K.J. (Karen), Thomas, G.R. (Roger), Wagemaker, G. (Gerard), Wognum, A.W. (Albert)   +6 more
core   +1 more source

Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia [PDF]

, 2011
Background Capillary leak syndrome (CLS) is a rare condition characterized by recurrent episodes of generalized edema and severe hypotension associated with hypoproteinemia. Interleukin-11 (IL-11) is a promising therapeutic agent for thrombocytopenia.
Wang Kai-Feng, Pan Hong-Ming, Lou Hai-Zhou, Shen Li-Rong, Zhu Xi-Yan   +4 more
core   +1 more source