Results 131 to 140 of about 4,128 (175)
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Effect of ethanol on thrombopoiesis
British Journal of Haematology, 1986Summary. Chronic ethanol abuse causes thrombocytopenia but the underlying mechanism is unknown. To determine the target cells involved, we examined the effects of the drug in vitro on both megakaryocyte progenitor cells (CFU‐Meg) and isolated, maturing megakaryocytes.
R F, Levine +3 more
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Seminars in Hematology, 2015
The production of platelets is a complex process that involves hematopoietic stem cells (HSCs), their differentiated progeny, the marrow microenvironment and hematopoietic cytokines. Much has been learned in the 110 years since James Homer Wright postulated that marrow megakaryocytes were responsible for blood platelet production, at a time when ...
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The production of platelets is a complex process that involves hematopoietic stem cells (HSCs), their differentiated progeny, the marrow microenvironment and hematopoietic cytokines. Much has been learned in the 110 years since James Homer Wright postulated that marrow megakaryocytes were responsible for blood platelet production, at a time when ...
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Proceedings, annual meeting, Electron Microscopy Society of America, 1990
In effective thrombopoies is has been inferred to occur in several disease sates from considerations of megakaryocyte mass and platelet kinetics. Microscopic examination has demonstrated increased numbers of megakaryocytes, with a typical forms particularly pronounced, in primary myelofibrosis.
JM Radley, SL Ellis
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In effective thrombopoies is has been inferred to occur in several disease sates from considerations of megakaryocyte mass and platelet kinetics. Microscopic examination has demonstrated increased numbers of megakaryocytes, with a typical forms particularly pronounced, in primary myelofibrosis.
JM Radley, SL Ellis
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The Journal of Pediatrics, 1965
An extract of fresh normal human plasma was shown to contain a factor capable of inducing platelet formation in rats. This thrombopoietic factor, which is labile on storage, was markedly deficient in the plasma of a child with chronic congenital thrombocytopenic purpura who responded repeatedly to infusions of normal human plasma.
Irving Schulman +4 more
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An extract of fresh normal human plasma was shown to contain a factor capable of inducing platelet formation in rats. This thrombopoietic factor, which is labile on storage, was markedly deficient in the plasma of a child with chronic congenital thrombocytopenic purpura who responded repeatedly to infusions of normal human plasma.
Irving Schulman +4 more
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Thrombopoiesis: Capturing the unicorn
Current Biology, 1994The elusive factor that stimulates megakaryocytes to produce platelets has at last been found; as well as its physiological interest, this factor--thrombopoietin--may be of considerable therapeutic importance.
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Effects of Endotoxemia on Thrombopoiesis in Men
Thrombosis and Haemostasis, 1999Summary Background. Febrile conditions are often associated with increased platelet turnover and refractoriness to platelet transfusions, although several pyrogenic cytokines enhance thrombopoiesis. This study aimed to characterize the effects of experimental human endotoxemia on platelet turnover and thrombopoiesis. Methods.
P, Stohlawetz +6 more
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Molecular Control of Megakaryopoiesis and Thrombopoiesis
International Journal of Hematology, 2002Megakaryopoiesis and subsequent thrombopoiesis occur through complex biologic steps: megakaryocyte precursors that developed from hematopoietic stem cells initially proliferate, then differentiate into mature polyploid megakaryocytes, and finally release platelets.
Itaru, Matsumura, Yuzuru, Kanakura
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Megakaryocytes and Thrombopoiesis
Journal of thrombosis and haemostasis, 2009http://onlinelibrary.wiley.com/doi/10.1111/jth.2009.7.issue-s2 ...
Hartwig, John H +5 more
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Pathologic thrombopoiesis of rheumatoid arthritis
Rheumatology International, 2003Rheumatoid arthritis (RA) is frequently complicated by thrombocytosis correlated with disease activity. The exact pathogenetic mechanism(s) that cause increased platelet counts in RA are still unknown. Recent investigations indicate that proinflammatory pleiotropic cytokines of RA also have megakaryocytopoietic/thrombopoietic properties.
Ihsan, Ertenli +5 more
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Megakaryopoiesis and Thrombopoiesis
2017Platelets are formed from the cytoplasm of megakaryocytes (MKs) that reside in the bone marrow (BM). MKs arise from hematopoietic stem cells in the osteoblastic niche in BM. The primary regulator of megakaryopoiesis is thrombopoietin. It is generally accepted that MKs migrate into the vascular niche and produce platelets; however, the mechanism by ...
Shugo Kowata, Yoji Ishida
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