Results 141 to 150 of about 4,399 (180)

Molecular Control of Megakaryopoiesis and Thrombopoiesis

International Journal of Hematology, 2002
Megakaryopoiesis and subsequent thrombopoiesis occur through complex biologic steps: megakaryocyte precursors that developed from hematopoietic stem cells initially proliferate, then differentiate into mature polyploid megakaryocytes, and finally release platelets.
Itaru, Matsumura, Yuzuru, Kanakura
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Pathologic thrombopoiesis of rheumatoid arthritis

Rheumatology International, 2003
Rheumatoid arthritis (RA) is frequently complicated by thrombocytosis correlated with disease activity. The exact pathogenetic mechanism(s) that cause increased platelet counts in RA are still unknown. Recent investigations indicate that proinflammatory pleiotropic cytokines of RA also have megakaryocytopoietic/thrombopoietic properties.
Celik, I, Haznedaroglu, IC, Calguneri, M, Ozturk, MA, Kiraz, S, Ertenli, I   +5 more
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Megakaryopoiesis and Thrombopoiesis

2017
Platelets are formed from the cytoplasm of megakaryocytes (MKs) that reside in the bone marrow (BM). MKs arise from hematopoietic stem cells in the osteoblastic niche in BM. The primary regulator of megakaryopoiesis is thrombopoietin. It is generally accepted that MKs migrate into the vascular niche and produce platelets; however, the mechanism by ...
Shugo Kowata, Yoji Ishida
openaire   +1 more source

Megakaryocytes and Thrombopoiesis

Journal of thrombosis and haemostasis, 2009
http://onlinelibrary.wiley.com/doi/10.1111/jth.2009.7.issue-s2 ...
Hartwig, John H, Begonja, Antonija, Falet, Herve, Patel-Hett, Sunita, Thon, Jonathan, Italiano, Joeseph   +5 more
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Transcriptional Regulation of Thrombopoiesis.

Blood, 2008
Abstract Over the past two decades, a number of key transcription factors have been identified that play essential roles in megakaryocyte development. These include GATA-1, GATA-2, Friend of GATA-1 (FOG-1), Runx-1, Cbf-β, Fli-1, GABPα, TEL, NF-E2 p45, Gfi-1b, and SCL/TAL.
Alan B. Cantor, Hui Huang, Andrew Woo, James Mann, Ming Yu, Thomas Akie, Nathan Tu, Barry H. Paw   +7 more
openaire   +1 more source

3D Model of Thrombopoiesis.

Blood, 2010
Abstract Abstract 1609 Background. The mechanisms that regulate megakaryocytic (Mk) development within the bone marrow environment remain poorly understood. The underlying relationships between Mk maturation and bone marrow components are key factors in this process.
Isabella Pallotta, Michael L. Lovett, David L. Kaplan, Alessandra Balduini   +3 more
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Thrombopoietins and Thrombopoiesis: A Clinical Perspective

Vox Sanguinis, 1998
AbstractSince the discovery of thrombopoietin four years ago there has been much interest in the clinical use of this growth factor and its impact on platelet transfusions. Two recombinant thrombopoietin molecules are currently under intense clinical investigation.
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Mechanisms of embryonic thrombopoiesis

2021
Platelets are generated by specialized cells called megakaryocytes (MKs) throughout embryonic development and adulthood. In adult bone marrow, MKs form and release proplatelets into circulation which mature into functional peripheral platelets. However, platelet generation in embryos is not fully understood. This is due to limitations of existing mouse
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Thrombopoietin: a tool for understanding thrombopoiesis

Journal of Thrombosis and Haemostasis, 2003
Although first proposed to be the primary regulator of platelet production 45 years ago, the gene for thrombopoietin was cloned only within the last decade. Since then, our understanding of megakaryocyte and platelet production has increased substantially, and it is now appreciated that in addition to its critical role in regulating thrombopoiesis, the
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Humoral control of thrombopoiesis.

Blood cells, 1981
There is increasing evidence that an important mechanism by which platelet production is regulated depends upon a humoral substance (thrombopoietin) that affects the production of platelets by megakaryocytes. Plasma from thrombocytopenic donors increases the rate of appearance or concentrations of subsequently administered Na235SO4 or selenomethionine ...
J, Levin, B L, Evatt
openaire   +1 more source