Results 141 to 150 of about 4,128 (175)

The bone marrow is the primary site of thrombopoiesis

Blood
AbstractMegakaryocytes (MKs) generate thousands of platelets over their lifespan. The roles of platelets in infection and inflammation has guided an interest to the study of extramedullary thrombopoiesis and therefore MKs have been increasingly reported within the spleen and lung.
Nathan L Asquith, Estelle Carminita, Virginia Camacho   +2 more
exaly   +3 more sources

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Transcriptional Regulation of Thrombopoiesis.

Blood, 2008
Abstract Over the past two decades, a number of key transcription factors have been identified that play essential roles in megakaryocyte development. These include GATA-1, GATA-2, Friend of GATA-1 (FOG-1), Runx-1, Cbf-β, Fli-1, GABPα, TEL, NF-E2 p45, Gfi-1b, and SCL/TAL.
Alan B. Cantor, Hui Huang, Andrew Woo, James Mann, Ming Yu, Thomas Akie, Nathan Tu, Barry H. Paw   +7 more
openaire   +1 more source

Mechanisms of embryonic thrombopoiesis

2021
Platelets are generated by specialized cells called megakaryocytes (MKs) throughout embryonic development and adulthood. In adult bone marrow, MKs form and release proplatelets into circulation which mature into functional peripheral platelets. However, platelet generation in embryos is not fully understood. This is due to limitations of existing mouse
openaire   +1 more source

3D Model of Thrombopoiesis.

Blood, 2010
Abstract Abstract 1609 Background. The mechanisms that regulate megakaryocytic (Mk) development within the bone marrow environment remain poorly understood. The underlying relationships between Mk maturation and bone marrow components are key factors in this process.
Isabella Pallotta, Michael L. Lovett, David L. Kaplan, Alessandra Balduini   +3 more
openaire   +1 more source

Thrombopoietin: a tool for understanding thrombopoiesis

Journal of Thrombosis and Haemostasis, 2003
Although first proposed to be the primary regulator of platelet production 45 years ago, the gene for thrombopoietin was cloned only within the last decade. Since then, our understanding of megakaryocyte and platelet production has increased substantially, and it is now appreciated that in addition to its critical role in regulating thrombopoiesis, the
openaire   +2 more sources

Thrombopoietins and Thrombopoiesis: A Clinical Perspective

Vox Sanguinis, 1998
AbstractSince the discovery of thrombopoietin four years ago there has been much interest in the clinical use of this growth factor and its impact on platelet transfusions. Two recombinant thrombopoietin molecules are currently under intense clinical investigation.
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Glucocorticoids regulate thrombopoiesis by remodeling the megakaryocyte transcriptome

Journal of Thrombosis and Haemostasis, 2023
John A Cidlowski, Matias Grodzielski
exaly  

Humoral control of thrombopoiesis.

Blood cells, 1981
There is increasing evidence that an important mechanism by which platelet production is regulated depends upon a humoral substance (thrombopoietin) that affects the production of platelets by megakaryocytes. Plasma from thrombocytopenic donors increases the rate of appearance or concentrations of subsequently administered Na235SO4 or selenomethionine ...
J, Levin, B L, Evatt
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Regulation of thrombopoiesis

American Journal of Physiology-Legacy Content, 1970
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[Current models of thrombopoiesis].

Der Pathologe, 2011
Platelets are essential corpuscular blood components required for hemostasis. They are released from precursor cells in the bone marrow by cellular fragmentation into the blood stream. Although some aspects of platelet biogenesis are well known, studying its occurrence in vivo has been mostly unsatisfactory.
openaire   +1 more source