Results 141 to 150 of about 15,812 (182)

Thrombopoietin in Patients with Hepatoblastoma

STEM CELLS, 1998
Marked thrombocytosis (over 50 x 10(4)/microl) is frequently seen in patients with hepatoblastoma. Thrombopoietin (TPO), c-mpl ligand, has recently been purified as the major physiological regulator of the thrombopoiesis and is mainly produced in the liver.
E, Komura, T, Matsumura, T, Kato, T, Tahara, Y, Tsunoda, T, Sawada   +5 more
openaire   +2 more sources

Thrombopoietin-receptor agonists

Current Opinion in Hematology, 2012
Thrombopoietin-receptor agonists (TPO-RAs) have been approved for use in immune thrombocytopenia (ITP) after showing safety and efficacy. There is increasing interest to expand the role of TPO-RAs, both in ITP as well as in other thrombocytopenic disorders.In ITP, more studies are providing evidence of TPO-RA efficacy and safety, as well as their ...
Paul A, Basciano, James B, Bussel
openaire   +2 more sources

Thrombopoietin — Clinically Realized?

New England Journal of Medicine, 1997
For approximately 30 years, hematologists have sought the humoral regulator of platelet production, thrombopoietin.1 Although a factor with the appropriate physiologic effects was partially purifie...
openaire   +2 more sources

Thrombopoietin

Cancer Investigation, 2001
R L, Basser, C G, Begley
openaire   +2 more sources

Protein Characteristics of Thrombopoietin

Stem Cells, 1996
Thrombopoietin (TPO) was purified from irradiated thrombocytopenic rat plasma. In the process of purification, some biochemical and biological characteristics were investigated. Rat plasma TPO was extremely hydrophobic and exhibited multiple peaks of activity on gel filtration.
openaire   +2 more sources

Thrombopoietin and Platelet Function

Seminars in Thrombosis and Hemostasis, 2006
In hematopoietic stem cells and megakaryocytes, the thrombopoietin (TPO) receptor signals to control proliferation, maturation, and antiapoptosis. In the anucleated platelet, much of this signaling appears out of place. Nevertheless, platelets possess TPO receptors and the cascades for transduction of TPO signals, but the final effect has shifted from ...
openaire   +2 more sources

Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis

Cell, 2023
Naotaka Tsutsumi, K Christopher Garcia
exaly  

Current Status of Thrombopoietin

1988
This review outlines the effects of a thrombocytopoiesis-stimulating factor (TSF or thrombopoietin) on thrombocytopoiesis and megakaryocytopoiesis. Thrombopoietin is a hormone that is now known to be a major controlling factor of blood platelet production.
openaire   +2 more sources

Thrombopoietin Bioassay

2004
Warren S, Alexander, Craig, Hyland
openaire   +2 more sources

The structure, function, and clinical use of the thrombopoietin receptor agonist avatrombopag

Blood Reviews, 2022
David J Kuter
exaly