Results 91 to 100 of about 1,394,911 (165)

The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin [PDF]

, 2017
A well-functioning hematopoietic system requires a certain robustness and flexibility to maintain appropriate quantities of functional mature blood cells, such as red blood cells and platelets.
Stefan N. Constantinescu, Jean-Philippe Defour, Constantinescu, SN, Varghese, Leila, Varghese, LN, Constantinescu, Stefan N., Christian Pecquet, Pecquet, Christian, Leila N. Varghese, Pecquet, C, Defour, Jean-Philippe, Defour, JP   +11 more
core   +1 more source

Haemostatic imbalance in a patient with psoriasis

Journal of Clinical and Scientific Research
Psoriasis is a chronic immune-mediated inflammatory skin disease that if left untreated, can impair most of the systems, especially the haemostatic system.
Sasidharan Athira, Rafi Aboobacker Mohamed   +1 more
doaj   +1 more source

Biologic aspects of thrombopoietin and the development of novel thrombopoietic agents for clinical use

, 2007
Thrombocytopenia is a frequent finding in several clinical settings, including bone marrow failure associated with various disorders, immune-mediated thrombocytopenia, and chronic liver diseases.
Evangelista M. L., AMADORI, SERGIO, Stasi R., Evangelista M.L., Amadori S., Stasi R.   +3 more
core   +1 more source

Thrombotic risk in patients with primary immune thrombocytopenia is only mildly increased and explained by personal and treatment-related risk factors

, 2014
An increased risk of thrombosis has been reported in primary immune thrombocytopenia (ITP) and with the use of thrombopoietin (TPO) receptor agonists, on the basis of population studies using administrative ...
De Stefano, Valerio
core   +1 more source

ITP: Tregs come to the rescue

, 2010
In this issue of Blood, Bao et al report an increase in regulatory T-cell activity in patients with ITP treated with thrombopoietin receptor (TPO-R) agonists.1 This finding implies that TPO-R agonists may have an unexpected immune-regulatory activity. If
Beng H. Chong
core   +1 more source

THROMBOPOIETIN RECEPTOR FRAGMENTS AND USES THEREOF

, 2023
The present invention relates to a polypeptide comprising fragments of the extracellular domain of thrombopoietin receptor, a fusion protein and a pharmaceutical composition comprising said polypeptide, and uses ...
UNIVERSITE CATHOLIQUE DE LOUVAIN, Constantinescu, Stefan N., Nedelec, Audrey, Papadopoulos, Nicolas   +3 more
core  

Thrombopoietin-receptor agonists in haematological disorders:The Danish experience

, 2012
The objective of this study was to investigate the use of thrombopoietin-receptor agonists (TPO-ra) in patients with refractory primary immune thrombocytopenia (ITP) as well as off-label use of TPO-ra in Danish haematology departments.
Frederiksen, H., Hasselbalch, Hans, Gudbrandsdottir, Sif, Frederiksen, Henrik; id_orcid, Hasselbalch, H., Gudbrandsdottir, S.   +5 more
core   +1 more source

Thrombopoietin receptor agonists for the treatment of inherited thrombocytopenia

Haematologica, 2020
Michael Makris
doaj   +1 more source

Clinical and laboratory aspects of patients diagnosed with various inherited platelet disorders

Research and Practice in Thrombosis and Haemostasis
Background: Inherited platelet disorders (IPDs) are characterized by thrombocytopenia, platelet dysfunction, or both, leading to recurrent bleeding and diagnostic challenges.
Veysel Gök, Alper Ozcan, Fatma Türkan Mutlu, Ebru Yılmaz, Deniz Kocak Göl, Mustafa Ozay, Baver Demir, Hüseyin Taskiran, Hasan Bas, Mehmet Burak Mutlu, Muhammet Ensar Dogan, Atil Bisgin, Ido Somekh, Meino Rohlfs, Munis Dundar, Yusuf Ozkul, Christoph Klein, Musa Karakukcu, Ekrem Unal   +18 more
doaj   +1 more source

Thrombopoietin Receptor Agonists for Chemotherapy-Induced Thrombocytopenia: A Systematic Review and Network Meta-Analysis

Journal of Clinical Question
Background: Chemotherapy-induced thrombocytopenia (CIT) can lead to chemotherapy delays, dose reductions, and the need for platelet transfusions. However, comparative evidence for thrombopoietin receptor agonists (TPO-RAs) is limited.
Yong-Mei Guo, Yan Zhao, Toshiyoshi Maeda, Nouhaila Ezzaoui, Chinwebudu M. Melford   +4 more
doaj   +1 more source