Results 91 to 100 of about 523,717 (316)

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Efficacy and safety of mechanical pulmonary valve replacement: a comprehensive systematic review and meta-analysis

Journal of Cardiothoracic Surgery
Background Pulmonary valve replacement (PVR) is the most common valve replacement procedure for pulmonary valve dysfunction in congenital heart diseases (CHD).
Ali Rafati, Sina Rashedi, Yeganeh Pasebani, Milad Vahedinejad, Hamed Ghoshouni, Yaser Toloueitabar, Mostafa Mousavizadeh, Sedigheh Saedi, Amirhosein Jalali, Zahra Khajali, Hassan Tatari, Fahimeh Farrokhzadeh, Hooman Bakhshandeh, Maziar Gholampour Dehaki, Behshid Ghadrdoost, Parham Sadeghipour   +15 more
doaj   +1 more source

ON A CASE OF THROMBOSIS. [PDF]

The Lancet, 1884
n ...
openaire   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Longitudinal assessment of cerebral infarcts and small vessel disease using magnetic resonance imaging in antiphospholipid syndrome: A single‐centre retrospective study

eJHaem
Introduction Stroke is the most frequent arterial thrombosis in antiphospholipid syndrome (APS) with high rates of recurrence. Methods and patients A retrospective, single‐centre 10‐year review of patients with APS having sequential cerebral magnetic ...
Yishi Tan, Andrew J. Doyle, Jayant Kumar, Peter Somerville, Uzma Faruqi, Anicee Danaee, Pu‐Lin Luo, Beverley J. Hunt, Karen A. Breen   +8 more
doaj   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

Rivaroxaban versus Enoxaparin in Patients with Radial Artery Occlusion after Transradial Coronary Catheterization: A Pilot Randomization Trial

Vascular Specialist International
The radial artery is currently the main vascular access site for cardiac catheterization. Radial artery occlusion (RAO), although a relatively silent complication, raises concerns because of its potential impact on future procedures.
Mohsen Maadani, Soudabeh Shafiee Ardestani, Farnaz Rafiee, Kiara Rezaei-Kalantari, Parham Rabiee, Yasmin Mohtasham Kia, Ali Zahedmehr, Bahram Mohebbi, Armin Elahifar, Ehsan Khalilipur, Ata Firouzi, Parham Sadeghipour   +11 more
doaj   +1 more source

蛋白C缺乏及蛋白S缺乏是台灣中國人靜脈栓塞好發症最重要之危險因子

, 2009
The relative risks (odds ratio, OR) of various risk factors for venous thrombophilia, including sex, antithrombin III, protein C (PC), protein S (PS) and plasminogen deficiencies, and C677T homozygous mutation of methylenetetrahydrofolate reductase gene ...
沈銘鏡;林正修;蔡偉, SHEN, MING-CHING;LIN, JEN-SHIOU;TSAY, WOEI   +1 more
core  

Factor V Leiden, prothrombin G20210A and protein C mutation frequency in Turkish venous thrombosis patients

, 2008
Several inherited polymorphisms are associated with risk of venous thrombosis, including Mutation at codon 506 of the factor V gene, mutation at position 20210 of the prothrombin gene, and mutations in the protein C gene.
Buyru, Nur, Altinisik, Julide, Cengiz, Mujgan, Ates, Omer, Ulutin, Turgut   +4 more
core   +1 more source

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source