Results 131 to 140 of about 1,025,996 (357)

Thrombotic Storm: When Thrombosis Begets Thrombosis

The American Journal of Medicine, 1998
Patients with hypercoagulability may present with a single thrombosis and subsequently develop progressive thromboses at other sites. With inadequate therapy, the thrombotic process may self-perpetuate, leading to multiple thromboses and even death.
Department of Medicine, University of Florida, and Department of Veterans Affairs Medical Center, Gainesville, Florida, USA. ( host institution ), Kitchens, Craig S ( author )   +1 more
openaire   +3 more sources

Optimization of Magnetic Milli‐Spinner for Robotic Endovascular Intervention

Advanced Robotics Research, EarlyView.
This work presents the design optimization of a multifunctional magnetic milli‐spinner for high‐speed propulsion and efficient clot debulking. The optimized design achieves an ultrafast swimming velocity of 55 cm/s (≈175 body lengths/s) in saline water, enabling stable upstream swimming against strong physiological flows and establishing magnetic milli‐
Lu Lu, Luca Higgins, Jack Bernardo, Ruike Renee Zhao   +3 more
wiley   +1 more source

Identification of reference miRNAs in plasma useful for the study of oestrogen-responsive miRNAs associated with acquired Protein S deficiency in pregnancy

BMC Research Notes, 2017
Background Accumulating evidence indicate that circulating microRNAs (miRNAs) are useful independent non-invasive biomarkers, with unique miRNA signatures defined for various pathophysiological conditions.
J. W. Tay, I. James, Q. W. Hughes, J. Y. Tiao, R. I. Baker   +4 more
doaj   +1 more source

Coagulation abnormalities and thrombosis in patients with COVID-19

The Lancet Haematology, 2020
M. Levi, J. Thachil, T. Iba, J. Levy
semanticscholar   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Infrared thermography for detecting compensatory load in people with haemophilia: a cross-sectional study

Thrombosis Journal
Background Haemophilia, caused by deficiencies in factor VIII or IX, leads to deep tissue bleeding and haemophilic arthropathy. Bleeding, arthropathy, and the perioperative period of surgery for arthropathy are associated with severe pain.
Yuya Mawarikado, Asuka Sakata, Midori Shima, Chihiro Hosoda, Naoki Matsumoto, Ryohei Kawasaki, Kenichi Ogiwara, Shoko Furukawa, Naruto Shimonishi, Tetsuhiro Soeda, Kohei Tatsumi, Yusuke Inagaki, Akira Kido, Keiji Nogami   +13 more
doaj   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

A commitment to global collaboration, welcoming international participation and advancing science for the benefit of patients

Bleeding, Thrombosis and Vascular Biology
On behalf of the International Society on Thrombosis and Haemostasis (ISTH) Council and Annual Congress Planning Committee (ACPC)   As we prepare for the International Society on Thrombosis and Haemostasis (ISTH) 2025 Congress in Washington, D.C ...
Pantep Angchaisuksiri, Wolfram Ruf, Jeffrey Weitz, Sam Schulman, Guy A. Young   +4 more
doaj   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

Sepsis and obesity: a scoping review of diet-induced obesity murine models

Intensive Care Medicine Experimental
Background Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability to sepsis; however, some degree of obesity may be protective, called the “obesity paradox”.
Mikaela Eng, Keshikaa Suthaaharan, Logan Newton, Fatima Sheikh, Alison Fox-Robichaud, the National Preclinical Sepsis Platform, Sepsis Canada   +5 more
doaj   +1 more source