Results 61 to 70 of about 116,907 (303)

Complement Factor H Gene Variant in a Patient with Thrombotic Microangiopathy on a Mixed Clinical Background

Case Reports in Nephrology, 2021
We report the case of a patient with complement factor H gene variant, who developed thrombotic microangiopathy on a mixed clinical background. A 79-year-old woman was transferred to Sanjo General Hospital for maintenance hemodialysis.
Yoichi Iwafuchi, Tetsuo Morioka, Yuko Oyama, Shin Goto, Ichiei Narita   +4 more
doaj   +1 more source

Eculizumab in secondary atypical haemolytic uraemic syndrome [PDF]

, 2017
Background. Complement dysregulation occurs in thrombotic microangiopathies (TMAs) other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients have been reported previously to be successfully treated with eculizumab.
Aljama, Pedro, Arjona, Emi, Blasco, Miquel, Borrego, Josefa, Cao, Mercedes, Cavero, Teresa, Espinosa, Mario, Fuentes, Carolina, García, Alba, Gavela, Eva, González-Parra, Emilio, Gracia-Iguacel, Carolina, Huerta, Ana, Jarque, Ana, López, Antía, Macía, Manuel, Mendizabal, Santiago, Morales, Enrique, Portolés, José, Praga, Manuel, Quintana, Luis F., Rabasco, Cristina, Rodríguez de Córdoba, Santiago, Rojas-Rivera, Jorge, Romera, Ana María, Román, Elena, Sevillano, Ángel, Ávila, Ana   +27 more
core   +2 more sources

Pulmonary tumor thrombotic microangiopathy successfully treated with corticosteroids: a case report

Journal of Medical Case Reports, 2017
Background Pulmonary tumor thrombotic microangiopathy is a special type of tumor thromboembolism. We report the case of a patient who developed pulmonary tumor thrombotic microangiopathy with alveolar hemorrhage.
Shinichi Miyazaki, Takuya Ikeda, Genshi Ito, Masahide Inoue, Keiji Nara, Yuko Nishinaga, Yoshinori Hasegawa   +6 more
doaj   +1 more source

COVID-19 and thrombotic microangiopathy

Акушерство, гинекология и репродукция, 2022
As shown by numerous studies conducted during the pandemic, the severe course of COVID-19 is accompanied by multiple organ failure. Cytokine storm, hypercoagulation, complement hyperactivation and other arms comprise the overall picture of the ...
E. V. Sluhanchuk, V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, A. S. Shkoda, O. P. Artyukov, V. I. Tsibizova, A. L. Mishchenko, K. N. Grigorieva, J.-С. Gris, E. Elalamy, A. D. Makatsariya   +11 more
doaj   +1 more source

Everolimus, Cyclosporine, and Thrombotic Microangiopathy: Clinical Role and Preventive Tools in Renal Transplantation [PDF]

, 2014
INTRODUCTION: Thrombotic microangiopathy (TMA) is characterized by endothelial cell injury and formation of fibrin thrombi within capillary and arterioles. In renal allograft recipients, TMA mainly presents as hemolytic uremic syndrome.
Baisi, Alberto, BOTTA, Carmine, CAPPELLI, Gianni, Decenzio, Bonucchi, FONTANA, FRANCESCO, GRANITO, MARIA, MAGNONI, Giacomo, MORI, Giacomo, Nava, Fabio, Sollazzo, A.   +9 more
core   +1 more source

Thrombotic Microangiopathy Complicating Cyclosporine in Renal Transplant Patients

Advanced Medical Journal, 2023
Background and objectives: Experience with cyclosporine associated thrombotic microangiopathy in renal allograft recipients is generally anecdotal; detailed descriptions of clinical behavior, therapeutic options and experience are also anecdotal and few.
Safa Al-Mukhtar
doaj   +1 more source

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

Advanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, Baixin Shen, Min Gu, Zijie Wang   +12 more
wiley   +1 more source

Kidney disease in lupus is not always 'lupus nephritis' [PDF]

, 2013
In lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current classification of the International Society of Nephrology/Renal Pathology ...
A Rahman, D Song, Hans-Joachim Anders, HJ Anders, Jan J Weening, JJ Weening   +5 more
core   +4 more sources

Interferon-complement loop in transplant-associated thrombotic microangiopathy.

Blood Advances, 2020
Transplant-associated thrombotic microangiopathy (TA-TMA) is an important cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The complement inhibitor eculizumab improves TA-TMA, but not all patients respond to therapy,
S. Jodele, M. Medvedovic, Nathan Luebbering, Jenny Chen, C. Dandoy, B. Laskin, S. Davies   +6 more
semanticscholar   +1 more source

Cancer and Thrombotic Microangiopathy [PDF]

Journal of Oncology Practice, 2016
Cancer-Associated Thrombotic Microangiopathy Thrombotic microangiopathy (TMA) is a general term that describes the clinical features of thrombocytopenia and microangiopathic hemolytic anemia, in conjunction with a raised lactate dehydrogenase level, reticulocytosis, and often hyperbilirubinemia.
openaire   +3 more sources