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Key content The epidemiology and pathophysiology of AFLP, HELLP syndrome and infectious viral hepatitis in late pregnancy. Clinical presentation, diagnosis and management of these conditions. Complications (maternal and fetal) and how these can be managed. The role of a multidisciplinary team in management.
Victor N. Chilaka+4 more
wiley +1 more source
BMQ: Boston Medical Quarterly was published from 1950-1966 by the Boston University School of Medicine and the Massachusetts Memorial ...
Antuna, Juan+25 more
core
ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis [PDF]
Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis.
Jones, GC, Riley, GP
core +2 more sources
Introduction: Caplacizumab is a humanized anti-von Willebrand Factor (vWF) Nanobody® for the treatment of acquired Thrombotic Thrombocytopenic Purpura (aTTP). Caplacizumab targets the A1-domain of vWF, inhibiting the interaction between vWF and platelets.
M. Sargentini‐Maier+5 more
semanticscholar +1 more source
ABSTRACT Xenotransplantation is becoming an emerging field of interest for the treatment of end‐stage heart disease. In fact, the shortage of human heart donors in European countries requires the increasing investigation of alternative strategies such as heart xenotransplantation.
Nicola Pradegan+6 more
wiley +1 more source
A case of congenital TTP presenting with microganiopathy in adulthood [PDF]
BACKGROUND: Congenital thrombotic thrombocytopenic purpura (TTP), also known as Upshaw-Schulman Syndrome is a rare inherited deficiency of ADAMTS13. Unlike the more common acquired TTP which is characterized by an acquired inhibitor of ADAMTS13, patients
Andrea K Kew+2 more
core +1 more source
ABSTRACT Shiga toxin‐producing Escherichia coli (STEC) are pathogenic E. coli strains that have been associated with a wide range of human clinical illness ranging from mild diarrhoea to bloody diarrhoea (BD) and haemolytic uremic syndrome (HUS). In its opinion of 18 May 2017, the French Agency for Food, Environmental and Occupational Health and Safety
Philippe Fravalo+33 more
wiley +1 more source
Frequency and Significance of HIV Infection among Patients Diagnosed with Thrombotic Thrombocytopenic Purpura [PDF]
Background. Case series of patients with a diagnosis of thrombotic thrombocytopenic purpura (TTP) have reported different frequencies of human immunodeficiency virus (HIV) infection; some series suggest that HIV infection may cause TTP. Methods.
Benjamin, Melody+7 more
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Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura [PDF]
Complement dysregulation is key in the pathogenesis of atypical Haemolytic Uraemic Syndrome (aHUS), but no clear role for complement has been identified in Thrombotic Thrombocytopenic Purpura (TTP).
Heelas, E+4 more
core +1 more source