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Thrombotic Thrombocytopenic Purpura
New England Journal of Medicine, 2019Thrombotic Thrombocytopenic Purpura A 35-year-old man presented with a 2-day history of abdominal pain and headache. A peripheral-blood smear showed numerous schistocytes, and a diagnosis of thrombotic thrombocytopenic purpura was made.
Shruti Bhandari, Rohit Kumar
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THROMBOTIC THROMBOCYTOPENIC PURPURA
Annals of Internal Medicine, 1953Excerpt Thrombotic thrombocytopenic purpura is a rare disease of which only a few cases have been diagnosed ante mortem.4Because of the rarity of diagnosis, other than at the autopsy table, few lab...
W S, GREEN, T W, GREEN
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Postoperative thrombotic thrombocytopenic purpura
Surgery Today, 2013Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease characterized by acute episodes of thrombocytopenia and microangiopathic hemolytic anemia occurring due to platelet and von Willebrand factor deposition and hyaline thrombi formation in arterioles and capillaries throughout the body, which results in organ ischemia.
Ahmet Emre, Eskazan +2 more
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Thrombotic Thrombocytopenic Purpura
JAMA: The Journal of the American Medical Association, 1982Though thrombotic thrombocytopenic purpura (TTP) is not a common disorder, having an estimated annual incidence of one per million population, it merits attention.1First, it afflicts those in the prime of life between the third and fourth decade. Second, it generally runs a fulminant course with mortality in excess of 8096.
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Thrombotic Thrombocytopenic Purpura
Annals of Internal Medicine, 1980Excerpt Originally described in 1925 (1), thrombotic thrombocytopenic purpura remained until recently a fulminating and rapidly fatal disorder. Fortunately, it has been rare.
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Thrombotic Thrombocytopenic Purpura
Annual Review of Medicine, 1988Platelet thrombus formation in small vessels is triggered by certain stimuli, including vascular injury, primary platelet agglutination, or both. The formation and dissolution of platelet thrombi is modulated by proteolysis, plasma factors, PGI2 synthesis and stability, and immune mechanisms.
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Platelets: Thrombotic Thrombocytopenic Purpura
Hematology, 2002Abstract Abnormalities of plasma von Willebrand factor (VWF) have been recognized to be associated with thrombotic thrombocytopenic purpura (TTP) for over 20 years. Patients with chronic, relapsing TTP have VWF multimers that are larger than normal, similar in size to those secreted by cultured endothelial cells. Recent observations have
James N, George +2 more
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Thrombotic thrombocytopenic purpura in pregnancy
BJOG: An International Journal of Obstetrics & Gynaecology, 1982Summary. A 20 week primigravida with intrauterine fetal death and the rare occurrence of thrombotic thrombocytopenic purpura (TTP) in pregnancy is presented. Aprotinin has been used to overcome uterine inertia non‐responsive to oxytocin stimulation. TTP was successfully treated with repeated plasmaphereses.
M, Atlas +4 more
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Autoimmunity in Thrombotic Thrombocytopenic Purpura
Seminars in Thrombosis and Hemostasis, 2005In the last few years, an autoimmune hypothesis for the pathogenesis of thrombotic thrombocytopenic purpura (TTP) has been proposed often, with variable success because of inconsistent supporting data. We are now aware that at least one subgroup of TTP patients does present with pathogenic autoantibodies (i.e, anti-ADAMTS13); this group consequently is
Porta, Camillo +2 more
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Thrombotic Thrombocytopenic Purpura Today
Hospital Practice, 1999Thrombotic thrombocytopenic purpura (TTP) usually responds to plasma exchange and plasma infusion. However, until recently, it was not clear how the treatment works. New understanding of the pathophysiology of TTP has clarified that issue and suggested new therapies that may eliminate plasma infusion and its risks.
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