Results 51 to 60 of about 52,108 (298)

Characterization and treatment of congenital thrombotic thrombocytopenic purpura.

Blood, 2019
Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra-rare thrombomicroangiopathy caused by an inherited deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13).
F. Alwan, C. Vendramin, R. Liesner, A. Clark, W. Lester, T. Dutt, W. Thomas, R. Gooding, T. Biss, Henry G. Watson, N. Cooper, R. Rayment, T. Cranfield, J. J. Veen, Q. Hill, Sarah Davis, J. Motwani, N. Bhatnagar, Nicole Priddee, M. Dávid, Maeve P. Crowley, J. Alamelu, H. Lyall, J. Westwood, M. Thomas, M. Thomas, M. Scully, M. Scully   +27 more
semanticscholar   +1 more source

Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome [PDF]

, 2010
Thrombotic microangiopathies (TMAs) are pathological conditions characterized by generalized microvascular occlusion by platelet thrombi, thrombocytopenia, and microangiopathic hemolytic anemia.
Mastroianni Kirsztajn, Gianna, Polito, Maria Goretti   +1 more
core   +2 more sources

Good practice statements (GPS) for the clinical care of patients with thrombotic thrombocytopenic purpura

Journal of Thrombosis and Haemostasis, 2020
Despite advances in treatment options for thrombotic thrombocytopenic purpura (TTP), there are still limited high quality data to inform clinicians regarding its management.
X. L. Zheng, S. Vesely, S. Cataland, P. Coppo, B. Geldziler, A. Iorio, M. Matsumoto, R. Mustafa, M. Pai, G. Rock, L. Russell, R. Tarawneh, J. Valdes, F. Peyvandi   +13 more
semanticscholar   +1 more source

Graves disease-induced thrombotic thrombocytopenic purpura: a case report

Journal of Medical Case Reports, 2019
Background Thrombotic thrombocytopenic purpura is an autoimmune disease that carries a high mortality. Very few case reports in the literature have described a relationship between Graves disease and thrombotic thrombocytopenic purpura. We present a case
Saira Chaughtai, Ijaz Khan, Varsha Gupta, Zeeshan Chaughtai, Raquel Ong, Arif Asif, Mohammad A. Hossain   +6 more
doaj   +1 more source

Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain

Haematologica, 2011
Background The majority of patients diagnosed with thrombotic thrombocytopenic purpura have autoantibodies directed towards the spacer domain of ADAMTS13.Design and Methods In this study we explored the epitope specificity and immunoglobulin class and ...
Wouter Pos, Nicoletta Sorvillo, Rob Fijnheer, Hendrik B. Feys, Paul H.P Kaijen, Gestur Vidarsson, Jan Voorberg   +6 more
doaj   +1 more source

The diagnosis and management of the haematologic manifestations of lupus [PDF]

, 2016
Haematological manifestations in systemic lupus erythematosus (SLE) are frequently observed. They are diverse and range from mild to severe.
Castro, SG, Isenberg, DA, Velo-García, A   +2 more
core   +1 more source

Vitamin B12 deficiency-induced pseudothrombotic microangiopathy without macrocytosis presenting with acute renal failure: a case report

Journal of Medical Case Reports, 2018
Background Vitamin B12 deficiency-induced thrombotic microangiopathy, known as pseudothrombotic microangiopathy, is a rare condition which resembles the clinical features of thrombotic thrombocytopenic purpura but requires a markedly different treatment.
Jennifer Vanoli, Andrea Carrer, Roberto Martorana, Guido Grassi, Michele Bombelli   +4 more
doaj   +1 more source

Reduced sensitivity of PLASMIC and French scores for the diagnosis of thrombotic thrombocytopenic purpura in older individuals

Transfusion, 2020
Thrombotic thrombocytopenic purpura (TTP) is a life‐threatening disorder characterized by thrombocytopenia, microangiopathic hemolysis, and ischemic organ failure.
A. Liu, Noor Dhaliwal, H. Upreti, Jamil Kasmani, Kathryn E. Dane, A. Moliterno, Evan M. Braunstein, R. Brodsky, Shruti Chaturvedi   +8 more
semanticscholar   +1 more source

How I treat thrombotic thrombocytopenic purpura in pregnancy.

Blood, 2020
Thrombotic thrombocytopenic purpura (TTP) is an acute, life-threatening thrombotic microangiopathy (TMA) caused by acquired or congenital severe deficiency of ADAMTS13.
B. Ferrari, F. Peyvandi
semanticscholar   +1 more source

Inherited thrombotic thrombocytopenic purpura mimicking immune thrombocytopenic purpura during pregnancy: a case report

Journal of Medical Case Reports, 2018
Background Thrombotic thrombocytopenic purpura is a very rare hereditary blood deficiency disorder of ADAMTS13 (von Willebrand factor-cleaving protease) and a life-threatening thrombotic microangiopathy characterized by thrombocytopenia and ...
Valter Romão de Souza, Ana Beatriz Cavalcante de Oliveira, Ana Maria Vanderlei, Amanda Queiroz da Mota Silveira Aroucha, Bruna Pontes Duarte, Aureli Nunes Machado, Lívia Netto Chaer, Cláudia Wanderley de Barros Correia, Maria da Conceição de Barros Correia, Manuela Freire Hazin Costa   +9 more
doaj   +1 more source