Results 161 to 170 of about 113,969,313 (213)

A pharmacophore model for sulphonyl-urea (-cyanoguanidine) compounds with dual action, thromboxane receptor antagonists and thromboxane synthase inhibitors

European Journal of Medicinal Chemistry, 2003
A 3D pharmacophore model was developed for original sulphonyl-urea (-cyanoguanidine) compounds and known molecules which behave both as thromboxane receptor antagonists and as thromboxane synthase inhibitors. Five recognition sites appear to be essential
Catherine Michaux, Johan Wouters, Stephanie Rolin   +2 more
exaly   +2 more sources

Induction of thromboxane synthase and prostaglandin endoperoxide synthase mRNAs in human erythroleukemia cells by phorbol ester [PDF]

FEBS Letters, 1992
The effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the mRNA levels of two enzymes, thromboxane synthase (TXS) and prostaglandin endoperoxide synthase (PES), responsible for the synthesis of thromboxane A2 from arachidonic acid, were studied in
R Nüsing, V Ullrich, C Yokoyama
exaly   +2 more sources

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Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion

Journal of Molecular Medicine, 2010
Thromboxane A(2) (TXA(2)) is a potent prothrombotic and immune modulating lipid mediator, which is implicated in cardiovascular diseases, in particular, atherosclerotic lesion development and thrombogenicity. Here, we tested the hypothesis that thromboxane synthase (TXAS), the obligate enzyme required to synthesize TXA(2), is expressed within the human
Anders, Gabrielsen, Hong, Qiu, Magnus, Bäck, Mats, Hamberg, Anne-Louise, Hemdahl, Hanna, Agardh, Lasse, Folkersen, Jesper, Swedenborg, Ulf, Hedin, Gabrielle, Paulsson-Berne, Jesper Z, Haeggström, Göran K, Hansson   +11 more
openaire   +2 more sources

Immunoaffinity purification of human thromboxane synthase

Archives of Biochemistry and Biophysics, 1990
A recently produced monoclonal antibody against human thromboxane synthase was used to purify the enzyme from platelets in a one-step procedure with good yields. The isolated protein exhibited a single band of about 58 kDa by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and contained one heme/mol.
R, Nüsing, S, Schneider-Voss, V, Ullrich   +2 more
openaire   +2 more sources

Differential expression of thromboxane A synthase and prostaglandin H synthase in megakaryocytic cell line [PDF]

Biochimica Et Biophysica Acta - Molecular Cell Research, 1995
We determined the expression of isoforms of prostaglandin H synthase (PGHS) and thromboxane A synthase (TXAS) in a human megakaryocyte cell line (MEG-01.
Kenneth Wu, Lee-Ho Wang
exaly   +2 more sources

Thromboxane synthase: structure and function of protein and gene

Prostaglandins and Other Lipid Mediators, 2002
Lee-Ho Wang
exaly   +3 more sources

Immobilization of catalytically active thromboxane synthase

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1988
Thromboxane synthase has been immobilized on phenyl-Sepharose beads by adsorption. The immobilized enzyme is catalytically active and has a slightly lower apparent Km for PGH2 than the detergent-solubilized enzyme. However, both imidazole- and pyridine-based inhibitors are equally effective in inhibiting the immobilized and solubilized enzyme ...
E R, Hall, G L, Townsend, W M, Tuan, D L, Venton   +3 more
openaire   +2 more sources

Probing Ligand Binding to Thromboxane Synthase

Biochemistry, 2013
Various fluorescence experiments and computer simulations were utilized to gain further understanding of thromboxane A(2) synthase (TXAS), which catalyzes an isomerization of prostaglandins H(2) to give rise to thromboxane A(2) along with a fragmentation reaction to 12-L-hydroxy-5,8,10-heptadecatrienoic acid and malondialdehyde.
Wei-Chih, Chao, Jyh-Feng, Lu, Jinn-Shyan, Wang, Hsiao-Ching, Yang, Tai-An, Pan, Steven Chun-Wei, Chou, Lee-Ho, Wang, Pi-Tai, Chou   +7 more
openaire   +2 more sources

Immunohistochemical localization of thromboxane receptor and thromboxane synthase in rat testis

Endocrinology, 1995
The cellular localization of thromboxane A2 receptor (TXR) and thromboxane synthase (TXS) in rat testes was examined with an antibody against the carboxyl-terminal tail of rat TXR and anti-porcine lung TXS antibody. By light microscopy immunoreactivity for TXR was shown to be present in spermatids, whereas spermatogonia, spermatocytes, and spermatozoa ...
N, Takahashi, K, Takeuchi, T, Abe, K, Murakami, M, Yamaguchi, K, Abe   +5 more
openaire   +3 more sources

Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: Correlation with plaque composition

Atherosclerosis, 2010
Prostaglandins, such as thromboxane A(2) (TxA(2)) and prostacyclin (PGI(2)), are bioactive lipid mediators that are implicated in the pathogenesis of atherosclerosis. In the current study, we tested the hypothesis that thromboxane synthase (TXAS), prostacyclin synthase (PGIS) and thromboxane receptor (TP) are expressed within the atherosclerotic lesion.
Tillmann, Cyrus, Tao, Ding, Domenico, Praticò   +2 more
openaire   +2 more sources