Results 111 to 120 of about 94,849 (390)

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

Agile Autonomous Driving using End-to-End Deep Imitation Learning

open access: yes, 2019
We present an end-to-end imitation learning system for agile, off-road autonomous driving using only low-cost sensors. By imitating a model predictive controller equipped with advanced sensors, we train a deep neural network control policy to map raw ...
Boots, Byron   +6 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

open access: yesFEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen   +2 more
wiley   +1 more source

Prediction of the Maximum Erosion Rate of Gas–Solid Two-Phase Flow Pipelines

open access: yesEnergies, 2018
Erosion is one of the important reasons for the thickness decrease and perforation of the pipe walls. Understanding the gas–solid two-phase flow pipe erosion mechanism is the basis for monitoring pipe erosion.
Jingyuan Xu   +3 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

open access: yesFEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li   +3 more
wiley   +1 more source

Throttle characteristics of multi-stage circumfluence nozzle during the separate-layer injection of CO2

open access: yesPetroleum, 2018
Separate-layer injection of CO2 is an important method to improve oil and gas production and recovery. Conventional single-stage nozzle is usually blocked by impurities, and the ice-barrier phenomenon is very common. To solve this problem, large-diameter
Haizhu Wang   +8 more
doaj   +1 more source

An Autonomous Surface Vehicle for Long Term Operations

open access: yes, 2018
Environmental monitoring of marine environments presents several challenges: the harshness of the environment, the often remote location, and most importantly, the vast area it covers.
Bukhsbaum, Sharon   +7 more
core   +1 more source

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