Results 31 to 40 of about 1,781 (263)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Multiparameter Collaborative Optimization and Analysis of the Non-Penetrating Tunnel Thruster

Journal of Marine Science and Engineering
A brand new non-penetrating tunnel thruster (short for NPT thruster) is proposed in this paper. The tunnel structural parameters of the thruster are optimized, and the performance and optimization effect are verified by experiments. First, the design and
Jinyu Guo, Yi Yang, Chao Wang, Zhiqiang Hu, Quan Zheng, Chuanzhi Fan   +5 more
doaj   +1 more source

Modelling Rocket System Performance Parameters

Academy Journal of Science and Engineering, 2022
What distinguishes the rocket system from airbreathing engines is that the rocket carries its own propellants, fuel and oxidants.  The modern rocket was originally developed for ballistic missiles.
Nnorom Achara
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

PROBE AND SPECTRAL INVESTIGATIONS OF ELECTRIC PROPULSION HALL EFFECT THRUSTER

Авіаційно-космічна техніка та технологія, 2017
The work is devoted to the study of a low-power Hall Effect Thruster. The currency of developing and increasing of integral characteristics of Hall Effect Thruster with power consumption less 0,3 kW is substantiated. The main directions of low-power Hall
Сергей Николаевич Кулагин
doaj   +1 more source

Numerical simulation and experimental research of LRIT-30 radio frequency ion thruster

AIP Advances, 2021
This study aimed at discussing the laws of the design parameters of a radio frequency (RF) ion thruster that influence the thruster performance, guide the performance optimization-oriented design of the thruster, and realize the high-accuracy continuous ...
Yanxu Pu, Xingda Li, Chenchen Wu, Xinfeng Sun, Lianjun Jia, Tianping Zhang, Fangwei Lv, Xinwei Chen   +7 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

A Computational Multiphysics Study of a Satellite Thruster

Engineering Proceedings
This work concerns a study of the thermomechanical behaviour of a commercial thruster for aerospace use. The thruster, operated using a bipropellant liquid mixture, is used for the motion and in-orbit altitude control of small telecommunications ...
Marcello A. Lepore, Marzio Piller, Mario Guagliano, Angelo R. Maligno   +3 more
doaj   +1 more source