Results 171 to 180 of about 12,489 (234)

T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2292-2304, November 2026.
Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3819-3830, November 2026.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

MEK1/2 Signalling establishes an alloreactive effector T cell program through SMAD4 during cardiac allograft rejection

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Upon T cell receptor (TCR) engagement by alloantigens, MEK1/2–ERK1/2 signalling promotes SMAD4 nuclear translocation and supports SMAD4‐dependent transcription of effector genes, including Ifng, Tnf, and Il2ra. This transcriptional program promotes alloreactive T cell effector function and contributes to cardiac allograft rejection.
Jiulu Zhao, Shuan Ran, Sijie Zhou, Yuan Li, Wang Zhan, Longyong Lai, Jikai Cui, Jiahong Xia, Jie Wu   +8 more
wiley   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, Volume 110, Issue 6, Page 452-462, November 2026.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Medjool Date Seed Polysaccharides Attenuate DSS‐Induced Colitis and Associated Hepatic Oxidative Injury in Mice, Accompanied by Gut Microbiota Alterations

Food Frontiers, Volume 7, Issue 6, November 2026.
Medjool date seeds were dried, milled, and extracted (80°C, 180 min), followed by centrifugation (1000 rpm, 15 min) and BCA analysis to obtain the polysaccharide fraction (MDSP), which was characterized by TEM, FTIR, XPS, NMR, UV‐Vis, and TGA. In Balb/c mice with DSS‐induced colitis (2.25% DSS, Day 1.15), oral administration of MDSP‐H (300 mg/Kg ...
Sadeeq Ullah, Caixia Guo, Xiao Zou, Junhong Xie, Hidayat Ullah, Muhammad Ishaq, Xiang Xiao, Wenqi Xu, Yanguang Cong, Chuanjiang Dong, Lu Li   +10 more
wiley   +1 more source

Food Properties, Bioactive Components, and Human Factors as Determinants of Low Nutrient Supply From Foods Can Be Improved With Adequate Nutritional Strategies

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Nutrient adequacy depends on food composition, bioaccessibility, absorption, physiological utilization, dietary access, supply stability, etc. Food properties, human health, agricultural conditions, and socioeconomic barriers influence nutrient delivery.
Chinaza Godswill Awuchi
wiley   +1 more source

Lineage switch in childhood leukemia

HemaSphere, Volume 10, Issue 11, November 2026.
Abstract Lineage switch (LS) is a rare but aggressive immunophenotypic transformation of acute leukemia associated with limited therapeutic options and poor clinical outcome. Although LS has been increasingly recognized in the era of CD19‐directed immunotherapies, its biological basis remains incompletely understood.
Katharina Daugs, Anna Prazmo, Anindita Roy, Arndt Borkhardt   +3 more
wiley   +1 more source

Integration of Aromatherapy and Essential Oils in Asthma Symptom Relief: A Narrative Review

Health Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background and Aims Asthma affects 262 million people globally, causing 455,000 preventable deaths, with higher mortality in low‐resource areas due to limited diagnosis and treatment. Aromatherapy, using bioactive essential oils (EOs), has emerged as a promising complementary approach for asthma symptom management.
Alex Odoom
wiley   +1 more source

Maladaptive DNA damage responses impair CD8 T‐cell fitness after allogeneic stem cell transplantation

HemaSphere, Volume 10, Issue 11, November 2026.
Tobias Ronny Haage, Domenica Saul, Romy Böttcher‐Loschinski, Martin Böttcher, Simon Völkl, Andreas Mackensen, Matthias Leisegang, Maurice Michel, Denise Walther, Dimitrios Mougiakakos   +9 more
wiley   +1 more source

Thyme Madonna

, 1994
openaire   +1 more source