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Thymic stromal lymphopoietin is regulated by the intracellular calcium
Cytokine, 2012The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the development and progression of allergic diseases such as atopic dermatitis. However, it has not been clarified that TSLP would be regulated by intracellular calcium in mast cells yet.
Na-Ra, Han +2 more
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Thymic Stromal Lymphopoietin: Master Switch for Allergic Inflammation [PDF]
Journal of Experimental Medicine, 2006 Thymic stromal lymphopoietin (TSLP) is an interleukin (IL) 7–like cytokine that triggers dendritic cell–mediated T helper (Th)2 inflammatory responses. TSLP is highly expressed by keratinocytes in skin lesions of patients with atopic dermatitis and is associated with dendritic cell activation in situ, suggesting that TSLP might be a master switch for ...
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The suppression of thymic stromal lymphopoietin expression by selenium
Amino Acids, 2011Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis. Selenium (Se) has various effects such as antioxidant, antitumor, antiulcer, and anti-inflammatory effects. However, the effect of Se on the production of TSLP has not been clarified. Thus, we investigated how Se inhibits
Phil-Dong, Moon, Hyung-Min, Kim
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Thymic stromal lymphopoietin and atopic diseases
Revue Française d'Allergologie, 2014Abstract Studies from the last ten years have seen great progress in recognizing the role of cytokine thymic stromal lymphopoietin (TSLP) in pathogenesis of atopic diseases, particularly atopic dermatitis (AD) and asthma. We provide here a review of the findings from four aspects: (1) TSLP: expression triggers and cellular sources; (2) TSLP receptor:
Leyva-Castillo, J.M., Li, M.
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The role of thymic stromal lymphopoietin in cutaneous disorders
Archives of Dermatological ResearchThymic Stromal Lymphopoietin (TSLP) is an important cytokine that invokes early immune responses. TSLP, an IL-7-like cytokine encoded by the TSLP gene, activates JAK1 and JAK2 signaling pathways, stimulating dendritic cells to induce inflammatory Th2 cells.
Alexander J. Jafari +2 more
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Therapy Directed Against Thymic Stromal Lymphopoietin
Drug News & Perspectives, 2008Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine and has been shown to be one of the factors released by epithelial cells following allergen contact with an important role instructing dendritic cells (DCs) to induce a T-helper type 2 (Th2) response.
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The Regulation of Thymic Stromal Lymphopoietin in Gut Immune Homeostasis
Digestive Diseases and Sciences, 2011Thymic stromal lymphopoietin is a novel IL-7-like cytokine that exerts immunomodulatory effects and is constitutively expressed by intestinal epithelial cells in response to commensal bacteria colonization. Thymic stromal lymphopoietin can directly or indirectly promote Th2 and Treg responses, and is believed to inhibit Th1 and Th17 responses and limit
Ming, Li +3 more
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Thymic stromal lymphopoietin is present in human breast milk
Pediatric Allergy and Immunology, 2010Macfarlane TV, Seager AL, Moller M, Morgan G, Thornton CA. Thymic stromal lymphopoietin (TSLP) is present in human breast milk. Pediatr Allergy Immunol 2010: 21: e454–e456. © 2010 The Authors Journal compilation © 2010 Blackwell MunksgaardThymic stromal lymphopoietin (TSLP) has emerged as a potential key mediator of both the initiation and maintenance ...
Trisha V, Macfarlane +4 more
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Functions of thymic stromal lymphopoietin in non-allergic diseases
Cellular Immunology, 2015Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine produced mainly by epithelial cells. Many studies indicate that TSLP contributes to promote T helper (Th) 2 immune responses which are associated with the pathogenesis of allergic inflammatory diseases.
Guoqing, Ying +3 more
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Role of Thymic Stromal Lymphopoietin in the Pathogenesis of Nasal Polyposis
The American Journal of the Medical Sciences, 2011Polyposis is an end form of chronic mucosal inflammation in a number of disorders and has an important impact on patient's life quality. Thymic stromal lymphopoietin (TSLP) is involved in many inflammatory processes such as asthma and allergic rhinitis (AR).
Tao, Liu +8 more
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