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Pruritus as a Distinctive Feature of Type 2 Inflammation [PDF]
Vaccines, 2021 Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus might have a tremendous impact on patients’ quality of life and strongly interfere with sleep, social, and work activities.
Simone Garcovich +5 more
doaj +5 more sources
Targeting type 2 inflammation in dermatology: mechanisms and clinical implications [PDF]
Frontiers in ImmunologyType 2 inflammation is a fundamental immunologic pathway underlying a growing spectrum of dermatologic diseases. While classically associated with atopic dermatitis, type 2 immune responses are increasingly recognized as key contributors to prurigo ...
Nicole Khalil +2 more
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Biomarkers of type 2 and non-type 2 inflammation in asthma exacerbations
Central European Journal of ImmunologyIntroduction In adult-onset asthma, two major endotypes have been proposed: T2 with eosinophilia and non-T2 characterised by neutrophils and interleukin (IL)-17. The objective of the study was to examine the endotype marker profile in patients with severe asthma who were hospitalized for exacerbations, with a ...
Kosar M. Ali +6 more
doaj +4 more sources
Contributions of innate type 2 inflammation to adipose function [PDF]
Journal of Lipid Research, 2019 A critical contributor to the health consequences of the obesity epidemic is dysregulated adipose tissue (AT) homeostasis. While white, brown, and beige AT function is altered in obesity-related disease, white AT is marked by progressive inflammation and
W. Reid Bolus, Alyssa H. Hasty
doaj +3 more sources
Modulation of type 2 inflammation during grass pollen-specific sublingual immunotherapy [PDF]
Frontiers in ImmunologyIntroductionBoth ILC2 and Th2 cell subsets play a critical role as functional effector cells in the pathogenesis of allergic diseases. Although allergen-specific immunotherapy is currently the only disease-modifying therapy available for allergic ...
Lorenzo Salvati +16 more
doaj +2 more sources
Neuroplasticity and neuroimmune interactions with type 2 inflammation in asthma [PDF]
European Respiratory ReviewThe lungs are innervated by both afferent and efferent nerve fibres that regulate key respiratory functions, including the cough reflex, airway tone, mucus secretion, and the detection of mechanical and chemical stimuli.
Carli S. Koster +4 more
doaj +2 more sources
Examining the Role of Type 2 Inflammation in Eosinophilic Esophagitis
Gastro Hep Advances, 2022 Eosinophilic esophagitis (EoE) is a chronic type 2 inflammatory disease characterized by an eosinophilic inflammatory infiltrate in the esophagus, leading to remodeling, stricture formation, and fibrosis.
Mirna Chehade +11 more
doaj +3 more sources
Biologic therapies targeting type 2 inflammation in NSAID−exacerbated respiratory disease [PDF]
Frontiers in ImmunologyNonsteroidal anti−inflammatory drug-exacerbated respiratory disease (N−ERD) is an inflammatory airway disease characterized by adult−onset asthma, chronic rhinosinusitis with nasal polyps and hypersensitivity reactions to cyclooxygenase−1 (COX−1 ...
Piotr Szatkowski +3 more
doaj +2 more sources
Type 2 inflammation and cardiometabolic disease in middle-aged adults [PDF]
ERJ Open ResearchBackground Asthma has been associated with a higher risk for cardiometabolic disease. One possible explanation is the activation of type 2 inflammation.
Johanna Haglund +3 more
doaj +2 more sources
Type 2 Inflammation and Its Role in Dermatologic Diseases. [PDF]
Int J DermatolABSTRACT Atopic dermatitis, prurigo nodularis, and chronic spontaneous urticaria are immune‐mediated, inflammatory skin conditions characterized by intense itch and disease‐specific skin lesions. Despite their different clinical presentations, the three diseases are unified by an aberrant type 2 immune response involving type 2 ...
Chovatiya R +5 more
europepmc +3 more sources