Results 1 to 10 of about 1,471,060 (116)

Modulation of type 2 inflammation during grass pollen-specific sublingual immunotherapy [PDF]

Frontiers in Immunology
IntroductionBoth ILC2 and Th2 cell subsets play a critical role as functional effector cells in the pathogenesis of allergic diseases. Although allergen-specific immunotherapy is currently the only disease-modifying therapy available for allergic ...
Lorenzo Salvati, Lorenzo Salvati, Manuela Capone, Alessio Mazzoni, Alessio Mazzoni, Anna Vanni, Giulia Lamacchia, Cristina Scaletti, Paola Parronchi, Paola Parronchi, Francesco Liotta, Francesco Liotta, Francesco Annunziato, Francesco Annunziato, Lorenzo Cosmi, Lorenzo Cosmi, Laura Maggi   +16 more
doaj   +2 more sources

Neuroplasticity and neuroimmune interactions with type 2 inflammation in asthma [PDF]

European Respiratory Review
The lungs are innervated by both afferent and efferent nerve fibres that regulate key respiratory functions, including the cough reflex, airway tone, mucus secretion, and the detection of mechanical and chemical stimuli.
Carli S. Koster, Chiara Lavitola, Raluca Teodorescu, Bart A. Bakker, Reinoud Gosens   +4 more
doaj   +2 more sources

Type 2 inflammation and cardiometabolic disease in middle-aged adults [PDF]

ERJ Open Research
Background Asthma has been associated with a higher risk for cardiometabolic disease. One possible explanation is the activation of type 2 inflammation.
Johanna Haglund, Fredrik Sundbom, Andrei Malinovschi, Christer Janson   +3 more
doaj   +2 more sources

Beyond CCR7: dendritic cell migration in type 2 inflammation [PDF]

Frontiers in Immunology
Conventional dendritic cells (cDCs) are crucial antigen-presenting cells that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, and self-antigens. The migration of cDCs from peripheral tissues
Audrey Meloun, Audrey Meloun, Beatriz León   +2 more
doaj   +2 more sources

Correlation between bullous pemphigoid and type 2 inflammation

Pifu-xingbing zhenliaoxue zazhi, 2022
Bullous pemphigoid (BP) is one of the common autoimmune blister diseases that mainly affects the elderly. Most bullous pemphigoid patients have obvious symptom of pruritus, accompanied by elevated levels of serum total IgE, peripheral blood eosinophils ...
Yao ZHOU, Guomin LI, Zhijun XU, Jie XU, Jinjin ZHENG, Hao FANG, Ruzeng XUE   +6 more
doaj   +1 more source

Pruritus as a Distinctive Feature of Type 2 Inflammation

Vaccines, 2021
Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus might have a tremendous impact on patients’ quality of life and strongly interfere with sleep, social, and work activities.
Simone Garcovich, Martina Maurelli, Paolo Gisondi, Ketty Peris, Gil Yosipovitch, Giampiero Girolomoni   +5 more
doaj   +1 more source

Type 2 inflammation in asthma and other airway diseases

ERJ Open Research, 2022
Chronic inflammatory airway diseases, including asthma, chronic rhinosinusitis, eosinophilic COPD and allergic rhinitis are a global health concern.
Jorge Maspero, Yochai Adir, Mona Al-Ahmad, Carlos A. Celis-Preciado, Federico D. Colodenco, Pedro Giavina-Bianchi, Hani Lababidi, Olivier Ledanois, Bassam Mahoub, Diahn-Warng Perng, Juan C. Vazquez, Arzu Yorgancioglu   +11 more
doaj   +1 more source

Type 2 inflammatory diseases in atopic dermatitis: A short review

Indian Journal of Paediatric Dermatology, 2022
Type 2 inflammatory diseases are characterized by the dysregulation of the T helper (Th) 2 pathway, the prototype being atopic dermatitis (AD). The common inflammatory pathways, genetic risk factors, epidermal barrier dysfunction, parental atopy, and ...
Ankita Choudhary, Pooja Agarwal, Sandeep Kulkarni, Bhushan Madke   +3 more
doaj   +1 more source

LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation[S]

Journal of Lipid Research, 2019
Eicosanoids are lipid-mediator molecules with key roles in inflammatory skin diseases, such as psoriasis. Eicosanoids are released close to the source of inflammation, where they elicit local pleiotropic effects and dysregulations.
Cornelia Pipper, Natalie Bordag, Bernadette Reiter, Kyriakos Economides, Peter Florian, Thomas Birngruber, Frank Sinner, Manfred Bodenlenz, Anita Eberl   +8 more
doaj   +1 more source

CCL4 Functions as a Biomarker of Type 2 Airway Inflammation

Biomedicines, 2022
Eosinophilic airway inflammatory disease is associated with bronchial asthma, with eosinophilic chronic rhinosinusitis (ECRS) typical of refractory type 2 airway inflammation.
Yoshiki Kobayashi, Hanh Hong Chu, Akira Kanda, Yasutaka Yun, Masami Shimono, Linh Manh Nguyen, Akitoshi Mitani, Kensuke Suzuki, Mikiya Asako, Hiroshi Iwai   +9 more
doaj   +1 more source