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Pruritus as a Distinctive Feature of Type 2 Inflammation [PDF]
Vaccines, 2021 Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus might have a tremendous impact on patients’ quality of life and strongly interfere with sleep, social, and work activities.
Simone Garcovich +5 more
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Targeting type 2 inflammation in dermatology: mechanisms and clinical implications [PDF]
Frontiers in ImmunologyType 2 inflammation is a fundamental immunologic pathway underlying a growing spectrum of dermatologic diseases. While classically associated with atopic dermatitis, type 2 immune responses are increasingly recognized as key contributors to prurigo ...
Nicole Khalil +2 more
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Modulation of type 2 inflammation during grass pollen-specific sublingual immunotherapy [PDF]
Frontiers in ImmunologyIntroductionBoth ILC2 and Th2 cell subsets play a critical role as functional effector cells in the pathogenesis of allergic diseases. Although allergen-specific immunotherapy is currently the only disease-modifying therapy available for allergic ...
Lorenzo Salvati +16 more
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Biologic therapies targeting type 2 inflammation in NSAID−exacerbated respiratory disease [PDF]
Frontiers in ImmunologyNonsteroidal anti−inflammatory drug-exacerbated respiratory disease (N−ERD) is an inflammatory airway disease characterized by adult−onset asthma, chronic rhinosinusitis with nasal polyps and hypersensitivity reactions to cyclooxygenase−1 (COX−1 ...
Piotr Szatkowski +3 more
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Neuroplasticity and neuroimmune interactions with type 2 inflammation in asthma [PDF]
European Respiratory ReviewThe lungs are innervated by both afferent and efferent nerve fibres that regulate key respiratory functions, including the cough reflex, airway tone, mucus secretion, and the detection of mechanical and chemical stimuli.
Carli S. Koster +4 more
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Type 2 inflammation, bronchiectasis and clinical trials: expanding from MAHALE [PDF]
ERJ Open ResearchB. Shoshana Zha +1 more
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Correlation between bullous pemphigoid and type 2 inflammation
Pifu-xingbing zhenliaoxue zazhi, 2022 Bullous pemphigoid (BP) is one of the common autoimmune blister diseases that mainly affects the elderly. Most bullous pemphigoid patients have obvious symptom of pruritus, accompanied by elevated levels of serum total IgE, peripheral blood eosinophils ...
Yao ZHOU +6 more
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Type 2 inflammation in asthma and other airway diseases
ERJ Open Research, 2022 Chronic inflammatory airway diseases, including asthma, chronic rhinosinusitis, eosinophilic COPD and allergic rhinitis are a global health concern.
Jorge Maspero +11 more
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Type 2 inflammatory diseases in atopic dermatitis: A short review
Indian Journal of Paediatric Dermatology, 2022 Type 2 inflammatory diseases are characterized by the dysregulation of the T helper (Th) 2 pathway, the prototype being atopic dermatitis (AD). The common inflammatory pathways, genetic risk factors, epidermal barrier dysfunction, parental atopy, and ...
Ankita Choudhary +3 more
doaj +1 more source
Journal of Lipid Research, 2019 Eicosanoids are lipid-mediator molecules with key roles in inflammatory skin diseases, such as psoriasis. Eicosanoids are released close to the source of inflammation, where they elicit local pleiotropic effects and dysregulations.
Cornelia Pipper +8 more
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