Results 41 to 50 of about 31,231,377 (293)

Secondary Publication: New Aspects of Biologically Active Substances: Atopic Dermatitis

Tokyo Women's Medical University Journal
Atopic dermatitis is characterized by three factors: decreased skin barrier function, type 2 immune response, and itching. In recent years, the elucidation of the pathological condition of atopic dermatitis has progressed from the immunological aspect ...
Yuko Takenaka
doaj   +1 more source

The Role of Type 2 Inflammation in Schistosoma-Induced Pulmonary Hypertension

Frontiers in Immunology, 2019
Approximately 5% of individuals chronically infected with Schistosoma mansoni develop pulmonary hypertension (PH). The disease is progressive and often fatal, and treatment options are palliative, not curative. Recent studies have unraveled major players
Claudia S. Mickael, Brian B. Graham
doaj   +1 more source

Pathobiology of Type 2 Inflammation in Asthma and Nasal Polyposis

Journal of Clinical Medicine, 2023
Asthma and nasal polyposis often coexist and are frequently intertwined by tight pathogenic links, mainly consisting of the cellular and molecular pathways underpinning type 2 airway inflammation. The latter is characterized by a structural and functional impairment of the epithelial barrier, associated with the eosinophilic infiltration of both the ...
Corrado Pelaia, Giulia Pelaia, Angelantonio Maglio, Caterina Tinello, Luca Gallelli, Nicola Lombardo, Rosa Terracciano, Alessandro Vatrella   +7 more
openaire   +2 more sources

Real-World Evaluation of Dupilumab in the Long-Term Management of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps: A Focus on IL-4 and IL-13 Receptor Blockade

Medicina
Background and Objectives: Chronic rhinosinusitis (CRS) is a complex inflammatory condition of the nasal passages that severely impairs quality of life. Type 2 CRS is characterized by eosinophilic inflammation, driven by cytokines like IL-4, IL-5, and IL-
Nicola Lombardo, Aurelio D’Ecclesia, Emanuela Chiarella, Corrado Pelaia, Debbie Riccelli, Annamaria Ruzza, Nadia Lobello, Giovanna Lucia Piazzetta   +7 more
doaj   +1 more source

Dupilumab improve acquired reactive perforating collagenosis characterized by type 2 inflammation

Frontiers in Immunology, 2023
BackgroundAcquired reactive perforating collagenosis (ARPC) is a clinically challenging disease with an unclear pathogenesis.ObjectiveTo evaluate the efficacy and safety of dupilumab for the treatment of ARPC, and analyze the expression of type 2 ...
Ben Liu, Yibei Wu, Xiaoyan Wu, Xinyu Zhong, Ruzeng Xue, Zhenying Zhang   +5 more
doaj   +1 more source

Tanis: A Link Between Type 2 Diabetes and Inflammation? [PDF]

Diabetes, 2002
Here we describe a novel protein, which we have named Tanis, that is implicated in type 2 diabetes and inflammation. In Psammomys obesus, a unique polygenic animal model of type 2 diabetes and the metabolic syndrome, Tanis is expressed in the liver in inverse proportion to circulating glucose (P = 0.010) and insulin levels (P = 0.004) and in direct ...
Walder, Ken, Kantham, Lakshmi, McMillan, Janine S, Trevaskis, James, Kerr, Lyndal, De Silva, Andrea, Sunderland, Terry, Godde, Nathan, Gao, Yuan, Bishara, Natalie, Windmill, Kelly, Tenne-Brown, Janette, Augert, Guy, Zimmet, Paul Z, Collier, Greg R   +14 more
openaire   +4 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]

, 2011
p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Iversen, Lars, A Funding, JS Arthur, Johansen, Claus, Kragballe, Knud, BM Bibby, Lilleholt, Louise Langer, Funding, Anne, L Iversen, Bibby, Bo Martin, K Kragballe, C Johansen, Arthur, J. Simon C.; id_orcid, LL Lilleholt   +13 more
core   +1 more source

Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets

Frontiers in Physiology, 2022
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation, whose incidence is rising.
Francesca Racca, Francesca Racca, Gaia Pellegatta, Giuseppe Cataldo, Edoardo Vespa, Edoardo Vespa, Elisa Carlani, Corrado Pelaia, Giovanni Paoletti, Giovanni Paoletti, Maria Rita Messina, Maria Rita Messina, Emanuele Nappi, Emanuele Nappi, Giorgio Walter Canonica, Giorgio Walter Canonica, Alessandro Repici, Alessandro Repici, Enrico Heffler, Enrico Heffler   +19 more
doaj   +1 more source

Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie‐Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton   +11 more
wiley   +1 more source