Results 41 to 50 of about 102,290,503 (289)

Type 2 diabetes foot inflammation prevention reminder socks

Heliyon
It is not easy to determine the time between diagnosis and inflammation in patients with type 2 diabetes foot disease. In severe cases, it can lead to ulceration or even amputation.
Xiangfang Ren
doaj   +1 more source

Secondary Publication: New Aspects of Biologically Active Substances: Atopic Dermatitis

Tokyo Women's Medical University Journal
Atopic dermatitis is characterized by three factors: decreased skin barrier function, type 2 immune response, and itching. In recent years, the elucidation of the pathological condition of atopic dermatitis has progressed from the immunological aspect ...
Yuko Takenaka
doaj   +1 more source

The Role of Type 2 Inflammation in Schistosoma-Induced Pulmonary Hypertension

Frontiers in Immunology, 2019
Approximately 5% of individuals chronically infected with Schistosoma mansoni develop pulmonary hypertension (PH). The disease is progressive and often fatal, and treatment options are palliative, not curative. Recent studies have unraveled major players
Claudia S. Mickael, Brian B. Graham
doaj   +1 more source

Pathobiology of Type 2 Inflammation in Asthma and Nasal Polyposis

Journal of Clinical Medicine, 2023
Asthma and nasal polyposis often coexist and are frequently intertwined by tight pathogenic links, mainly consisting of the cellular and molecular pathways underpinning type 2 airway inflammation. The latter is characterized by a structural and functional impairment of the epithelial barrier, associated with the eosinophilic infiltration of both the ...
Corrado Pelaia, Giulia Pelaia, Angelantonio Maglio, Caterina Tinello, Luca Gallelli, Nicola Lombardo, Rosa Terracciano, Alessandro Vatrella   +7 more
openaire   +2 more sources

Real-World Evaluation of Dupilumab in the Long-Term Management of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps: A Focus on IL-4 and IL-13 Receptor Blockade

Medicina
Background and Objectives: Chronic rhinosinusitis (CRS) is a complex inflammatory condition of the nasal passages that severely impairs quality of life. Type 2 CRS is characterized by eosinophilic inflammation, driven by cytokines like IL-4, IL-5, and IL-
Nicola Lombardo, Aurelio D’Ecclesia, Emanuela Chiarella, Corrado Pelaia, Debbie Riccelli, Annamaria Ruzza, Nadia Lobello, Giovanna Lucia Piazzetta   +7 more
doaj   +1 more source

Dupilumab improve acquired reactive perforating collagenosis characterized by type 2 inflammation

Frontiers in Immunology, 2023
BackgroundAcquired reactive perforating collagenosis (ARPC) is a clinically challenging disease with an unclear pathogenesis.ObjectiveTo evaluate the efficacy and safety of dupilumab for the treatment of ARPC, and analyze the expression of type 2 ...
Ben Liu, Yibei Wu, Xiaoyan Wu, Xinyu Zhong, Ruzeng Xue, Zhenying Zhang   +5 more
doaj   +1 more source

Tanis: A Link Between Type 2 Diabetes and Inflammation? [PDF]

Diabetes, 2002
Here we describe a novel protein, which we have named Tanis, that is implicated in type 2 diabetes and inflammation. In Psammomys obesus, a unique polygenic animal model of type 2 diabetes and the metabolic syndrome, Tanis is expressed in the liver in inverse proportion to circulating glucose (P = 0.010) and insulin levels (P = 0.004) and in direct ...
Walder, Ken, Kantham, Lakshmi, McMillan, Janine S, Trevaskis, James, Kerr, Lyndal, De Silva, Andrea, Sunderland, Terry, Godde, Nathan, Gao, Yuan, Bishara, Natalie, Windmill, Kelly, Tenne-Brown, Janette, Augert, Guy, Zimmet, Paul Z, Collier, Greg R   +14 more
openaire   +4 more sources

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Nitric oxide in acute and chronic inflammation. [PDF]

, 2002
PhDNitric oxide (NO) is a signalling molecule formed when L-arginine is converted to L-citrulline by the enzyme NO synthase (NOS. NOS exists as three isoforms, ecNOS is constitutively expressed in endothelial cells and nNOS in neuronal cells, while a ...
Paul-Clark, Mark John
core   +2 more sources

Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice [PDF]

Fungal spores are abundant in the environment and a major cause of asthma. Originally characterised as a type 2 inflammatory disease, allergic airway inflammation that underpins asthma can also involve type 17 inflammation, which can exacerbate disease ...
EL Houlder (21930581), SAP Colombo (21973997), M Bertuzzi (21974003), SL Brown (14574785), S Baker (9861626), PC Cook (21924899), CR Thornton (21817148), FR Svedberg (21974000), L Boon (13158816), AS MacDonald (9344264), DP Conn (21973994), G Howell (13729981), JE Allen (14538209), JE Konkel (9720440), J Furlong-Silva (21973991)   +14 more
core   +6 more sources