Results 61 to 70 of about 31,231,377 (293)

MAJOR DEPRESSIVE DISORDER, TYPE 2 DIABETES MELLITUS AND INFLAMMATION

Trakia Journal of Sciences
Inflammation may play a key role in the pathogenesis of both depression and type 2 diabetes. However, elevated levels of circulating IL-6 are an independent predictor of type 2 diabetes and are thought to occurwith the development of ...
Y.Petkov
doaj   +1 more source

Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis

JID Innovations, 2022
Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple interacting systems. In AD, skin inflammation is caused by host–environment interactions involving keratinocytes as well as tissue-resident immune cells such as ...
Lisa A. Beck, Michael J. Cork, Masayuki Amagai, Anna De Benedetto, Kenji Kabashima, Jennifer D. Hamilton, Ana B. Rossi   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A basophil-fibroblast pro-inflammatory axis fuels type 2 skin inflammation

Cell Reports
Summary: Chronic inflammatory skin diseases arise from dysregulated interactions between tissue-resident and infiltrating cells, the complexity of which hinders disease understanding and treatment.
Ichiro Imanishi, Raman Gill, Alexis Wilder, Paula Restrepo, Arjun Nair, Inchul Cho, James G. Krueger, Emma Guttman-Yassky, Brian S. Kim, Andrew L. Ji   +9 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The role of air pollution in the aetiology of type 2 diabetes [PDF]

, 2015
Background. The public health burden of type 2 diabetes cannot be overestimated. Prevalence of type 2 diabetes is continuously increasing and has caused a great number of deaths and economic losses.
Eze, Ikenna Collins
core   +1 more source

Periostin activates distinct modules of inflammation and itching downstream of the type 2 inflammation pathway

, 2023
Atopic dermatitis (AD) is a chronic relapsing skin disease accompanied by recurrent itching. Although type 2 inflammation is dominant in allergic skin inflammation, it is not fully understood how non-type 2 inflammation co-exists with type 2 inflammation
Naoko Ejiri, Yamamoto, Sayaka, Nanri, Yasuhiro, Hitoshi Ikemitsu, Hironobu Takedomi, Misaki Koga, Ikemitsu, Hitoshi, Andoh, Tsugunobu, Kitajima, Isao, Takedomi, Hironobu, Sayaka Yamamoto, Yuko Honda, Tsugunobu Andoh, Kenji Izuhara, Kosuke Matsuda, Satoshi Nunomura, Daisuke Uta, Yasuhiro Nanri, Midori Kitajima, Matsuda, Kosuke, Kitajima, Midori, Nunomura, Satoshi, Uta, Daisuke, Conway, Simon J., Izuhara, Kenji, Simon J. Conway, Koga, Misaki, Honda, Yuko, Isao Kitajima, Ejiri, Naoko   +29 more
core   +1 more source

The impact of obesity and inflammation on metabolic risk factors for cardiovascular disease and type two diabetes in black and white South African women [PDF]

, 2011
[T]he overall aim of this thesis was to investigate the ethnic-specific role of inflammation in obesity and related metabolic risk factors associated with T2DM and CVD in apparently healthy black and white premenopausal South African ...
Evans, Juliet P
core   +1 more source