Results 71 to 80 of about 1,471,209 (258)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Recent Advances in biological targeted therapies for bronchial asthma (2024)
Allergy MedicineBronchial asthma is divided into type 2 and non-type 2 asthma based on the immunopathogenesis. Type 2 inflammation is an inflammation mediated by T helper 2 cells, group 2 innate lymphoid cells and sustained by a specific subset of cytokines.
Nan Su, Bin Cao
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Type 2 Inflammation Is Associated with Emphysema on Computed Tomography. [PDF]
Ann Am Thorac SocBhatt SP, Nakhmani A, Bodduluri S.
europepmc +3 more sources
Tasting type 2 inflammation in the airways [PDF]
Journal of Allergy and Clinical Immunology, 2018 Snelgrove, RJ, Lloyd, CM
openaire +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension
Frontiers in ImmunologyBackgroundSchistosomiasis is a common cause of pulmonary hypertension (PH) worldwide. Type 2 inflammation contributes to the development of Schistosoma-induced PH. Specifically, interstitial macrophages (IMs) derived from monocytes play a pivotal role by
Rahul Kumar +16 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Targeted Biologic Therapies in Severe Asthma: Mechanisms, Biomarkers, and Clinical Applications
PharmaceuticalsAsthma represents a heterogeneous disorder characterized by a dynamic balance between pro-inflammatory and anti-inflammatory forces, with allergic sensitization contributing substantially to airway hyperresponsiveness and remodeling.
Renata Maria Văruț +7 more
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