Results 91 to 100 of about 31,231,377 (293)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Adipose tissue derived factors in obesity, inflammation & energy homeostasis [PDF]

Obesity is the foremost contributory factor in the progression to type 2 diabetes mellitus (T2DM). Moreover, chronic inflammation, through activation of innate immunity is proposed to link obesity, insulin resistance and T2DM.
Kusminski, C. M.
core  

Therapeutic Effects of Quercetin on Inflammation, Obesity, and Type 2 Diabetes

Mediators of Inflammation, 2016
In previous studies, abdominal obesity has been related to total low-grade inflammation and in some cases has resulted in insulin resistance and other metabolism related disorders such as diabetes.
Shuang Chen, Hongmei Jiang, Xiaosong Wu, Jun Fang   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects [PDF]

, 2012
OBJECTIVE-To evaluate the changes in circulating endotoxin after a high-saturated fat meal to determine whether these effects depend on metabolic disease state.
Varma, M.C., Saravanan, Ponnusamy, Saravanan, P., Tripathi, Gyanendra, Kumar, Sudhesh, Sabico, Shaun, Sabico, S., O'Hare, J.P., McTernan, P. G., Harte, A. L., Varma, Madhusudhan C., Ceriello, A., Al-Attas, Omar S., McTernan, P.G., Al-Attas, O.S., Al-Daghri, Nasser M., Ceriello, Antonio, McGee, K. C., O'Hare, J. Paul, McGee, K.M., Al-Daghri, N.M., Kumar, S., Harte, A.L., Tripathi, G.   +23 more
core   +1 more source

Type 2 inflammation in cystic fibrosis: New insights

, 2022
Recently, type 2 inflammation has been recognized as one of the most critical factors participating in the pathogenesis of cystic fibrosis (CF). On the one hand, type 2 inflammation restores tissue homeostasis and contributes to the resolution of ...
Parisi, Giuseppe Fabio, Papale, Maria, Leonardi, Salvatore, Licari, Amelia, Manti, Sara, Marseglia, Gian Luigi   +5 more
core   +1 more source

Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention

, 2010
Alaa Badawi1, Amira Klip2, Pierre Haddad3, David EC Cole4, Bibiana Garcia Bailo1,5, Ahmed El-Sohemy5, Mohamed Karmali11Office for Biotechnology, Genomics and Population Health, Public Health Agency of Canada, Toronto, ON, Canada; 2Cell Biology Program ...
et al, Alaa Badawi, Amira Klip, Pierre Haddad   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin [PDF]

, 2012
Background: Evidence that selenium affects the risk of type-2 diabetes is conflicting, with observational studies and a few randomized trials showing both lower and higher risk linked to the level of selenium intake and status. We investigated the effect
Steinbrenner, Holger, Eliseo Guallar, Roberto Pastor-Barriuso, Stranges, S, Steinbrenner Holger, Blundell-Pound, G, Eliseo Guallar (27363), Gabrielle Blundell-Pound, Pastor-Barriuso, R, Margaret P Rayman, Pastor-Barriuso, Roberto, Blundell-Pound Gabrielle, Rayman, Margaret, Blundell-Pound, Gabrielle, Holger Steinbrenner, Stranges, Saverio, Roberto Pastor-Barriuso (62759), Gabrielle Blundell-Pound (135140), Stranges Saverio, Guallar, E, Guallar, Eliseo, Saverio Stranges, Rayman, Margaret P, Pastor-Barriuso, R., Holger Steinbrenner (135147), Steinbrenner, H, Rayman, MP, Saverio Stranges (73786), Pastor-Barriuso Roberto, Margaret P. Rayman (135136), Rayman Margaret P., Guallar Eliseo   +31 more
core   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source