Results 111 to 120 of about 31,231,377 (293)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The roles of secreted protein acidic and rich in cystiene (Sparc) in intestinal inflammation, healing and fibrosis [PDF]
, 2012 Secreted Protein Acidic and Rich in Cysteine (SPARC) is a matricellular protein expressed during tissue repair and regulates cell proliferation and migration.
Ng, Yoke Leng
core
Quantitative Expression of C-Type Lectin Receptors in Humans and Mice [PDF]
, 2012 C-type lectin receptors, their adaptor molecules and S-type lectins (galectins) are involved in the recognition of glycosylated self-antigens and pathogens.
Lech, Maciej +12 more
core +1 more source
Targeted Biologic Therapies in Severe Asthma: Mechanisms, Biomarkers, and Clinical Applications
PharmaceuticalsAsthma represents a heterogeneous disorder characterized by a dynamic balance between pro-inflammatory and anti-inflammatory forces, with allergic sensitization contributing substantially to airway hyperresponsiveness and remodeling.
Renata Maria Văruț +7 more
doaj +1 more source
Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation
Journal of Diabetes Research, 2017 Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood.
Chang Xia, Xiaoquan Rao, Jixin Zhong
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Nitric oxide synthase in skeletal muscle fibres of patients with type 2 diabetes [PDF]
, 2012 Muscle-derived nitric oxide (NO) mediates fundamental physiological actions on skeletal muscle including glucose uptake into muscle cells. Recently, we have shown that the altered glucose metabolism in skeletal muscle of patients with type 2 diabetes ...
Karla Punkt +5 more
core
Neuroimmune mechanisms of type 2 inflammation in the skin and lung
Allergology InternationalType 2 inflammation has a major role in barrier tissues such as the skin and airways and underlies common conditions including atopic dermatitis (AD) and asthma.
Masato Tamari, Aaron M. Ver Heul
doaj +1 more source
Type 2 Diabetes, PUFAs, and Vitamin D: Their Relation to Inflammation
Journal of Immunology Research, 2014 Chronic diseases have become one of the most important public health problems, due to their high costs for treatment and prevention. Until now, researchers have considered that the etiology of Type 2 diabetes mellitus (T2DM) is multifactorial.
Ana L. Guadarrama-López +2 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source