Results 101 to 110 of about 102,290,503 (289)

IL1RL1 asthma risk variants regulate airway type 2 inflammation [PDF]

, 2016
Genome-wide association studies of asthma have identified genetic variants in the IL1RL1 gene, but the molecular mechanisms conferring risk are unknown. IL1RL1 encodes the ST2 receptor (ST2L) for IL-33 and an inhibitory decoy receptor (sST2).
Michael A. Matthay, Nocka, Karl H, Lachowicz-Scroggins, Marrah E, Max A. Seibold, Agata Wesolowska-Andersen, Mason, Robert J, Karl H. Nocka, Joe Palandra, Hannah J. MacLeod, Lando Ringel, Lee, Jae W, Sheldon, Richard T, Louis Z. Sharp, Gordon, Erin D, Michael C. Peters, Palandra, Joe, Ringel, Lando, John V. Fahy, Jae W. Lee, Sharp, Louis Z, Wesolowska-Andersen, Agata, Matthay, Michael A, Peters, Michael C, Cydney L. Rios, Marrah E. Lachowicz-Scroggins, Seibold, Max A, Richard T. Sheldon, Rios, Cydney L, Erin D. Gordon, MacLeod, Hannah J, Jamie L. Everman, Robert J. Mason, Fahy, John V, Everman, Jamie L   +33 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Tasting type 2 inflammation in the airways [PDF]

Journal of Allergy and Clinical Immunology, 2018
Snelgrove, RJ, Lloyd, CM
openaire   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension

Frontiers in Immunology
BackgroundSchistosomiasis is a common cause of pulmonary hypertension (PH) worldwide. Type 2 inflammation contributes to the development of Schistosoma-induced PH. Specifically, interstitial macrophages (IMs) derived from monocytes play a pivotal role by
Rahul Kumar, Rahul Kumar, Sushil Kumar, Claudia Mickael, Dara Fonseca Balladares, Dara Fonseca Balladares, Kevin Nolan, Kevin Nolan, Michael H. Lee, Michael H. Lee, Linda Sanders, Julia Nilsson, Ari B. Molofsky, Rubin M. Tuder, Kurt R. Stenmark, Brian B. Graham, Brian B. Graham   +16 more
doaj   +1 more source

Effects of resveratrol in ınflammatory arthritis [PDF]

, 2007
Inflammation, Vol. 30, Nos. 1Y2, April 2007 ( 2006)Summary: Nuclear factor kappa B (NF-kB), is a pivotal transcription factor involved in the activation of the TNF-a and IL-1b genes.
Baysal, Özlem, Esenkaya, İrfan, Mızrak, Bülent, Elmalı, Nurzat, Harma, Ahmet   +4 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Targeted Biologic Therapies in Severe Asthma: Mechanisms, Biomarkers, and Clinical Applications

Pharmaceuticals
Asthma represents a heterogeneous disorder characterized by a dynamic balance between pro-inflammatory and anti-inflammatory forces, with allergic sensitization contributing substantially to airway hyperresponsiveness and remodeling.
Renata Maria Văruț, Dop Dalia, Kristina Radivojevic, Diana Maria Trasca, George-Alin Stoica, Niculescu Stefan Adrian, Niculescu Elena Carmen, Cristina Elena Singer   +7 more
doaj   +1 more source

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Journal of Diabetes Research, 2017
Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood.
Chang Xia, Xiaoquan Rao, Jixin Zhong
doaj   +1 more source

IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma [PDF]

, 2018
RATIONALE: Quantification of type 2 inflammation provided a molecular basis for heterogeneity in asthma. Non-type 2 pathways that contribute to asthma pathogenesis are not well understood.
Jung, Kyle L, Arron, Joseph R, David F. Choy, Kyle L. Jung, Nirav R. Bhakta, David J. Erle, Garudadri, Suresh, Owen D. Solberg, Lorna T. Zlock, Christine P. Nguyen, Bonser, Luke R, Pollack, Joshua L, John V. Fahy, Srilaxmi Nerella, Suresh Garudadri, Christenson, Stephanie A, Nguyen, Christine P, Solberg, Owen D, Erle, David J, Nerella, Srilaxmi, Joshua L. Pollack, Choy, David F, Langelier, Charles, Zlock, Lorna T, Joseph R. Arron, Prescott G. Woodruff, Stephanie A. Christenson, Joseph L. Derisi, Bhakta, Nirav R, Derisi, Joseph L, Fahy, John V, Woodruff, Prescott G, Luke R. Bonser, Charles Langelier   +33 more
core   +1 more source