Results 131 to 140 of about 102,290,503 (289)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Type 2 inflammation drives an airway basal stem cell program through insulin receptor substrate signaling

, 2023
Type 2 inflammation drives an airway basal stem cell program through insulin receptor substrate ...
Sachin Samuchiwal (18178216), Kathleen M Buchheit (18178222), Soumya Raychaudhuri (229153), Joshua A Boyce (18178243), Neil Bhattacharyya (16019924), Maria Gutierrez-Arcelus (170921), Xin Wang (91924), Qihua Ye (18178219), Nora A Barrett (18178246), Alice Z Maxfield (18178225), Rachel E Roditi (18178228), Regan W Bergmark (18178231), Deb Gakpo (18178237), Tanya M Laidlaw (18178240), Tessa Ryan (18178234), Minkyu Lee (9414611), Dan Dwyer (12413236), Nils R Hallen (18178213)   +17 more
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Stapokibart (CM310) targets IL-4Rα for the treatment of type 2 inflammation

iScience
Summary: Stapokibart (CM310) is a humanized IL-4Rα monoclonal antibody currently undergoing phase 3 trials for type 2 inflammatory diseases. In contrast to dupilumab, which bound exclusively to human IL-4Rα, stapokibart demonstrated cross-species ...
Wei Liu, Yan Zhao, Yanyun He, Xinyu Yan, Juntao Yu, Qin Song, Libo Zhang, Bohan Dong, Gang Xu, Changyu Wang, Jianzhong Zhang, Bo Chen   +11 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

The role of NLRP3 inflammasome in type 2 inflammation related diseases

Autoimmunity
Type 2 inflammation related diseases, such as atopic dermatitis, asthma, and allergic rhinitis, are diverse and affect multiple systems in the human body.
Shenming Xu, Dan Wang, Lina Tan, Jianyun Lu   +3 more
doaj   +1 more source

HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling

, 2020
HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle ...
A Ullah (13375230), RJ Steptoe (14458038), Z Loh (13371966), SB Mazzone (14458035), E Porrello (13375239), K Lane (9875315), WJ Gan (14458023), AA Sikder (14458029), PD Sly (14453628), JP Lynch (11118801), MB Sukkar (14458041), S Phipps (13370940), KM Spann (14457480), RB Werder (14458026), JW Upham (14458044), V Zhang (13370919), J Simpson (8412294), CB Sim (14458032)   +17 more
core  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source