Results 151 to 160 of about 1,471,209 (258)

Integrated Single-Cell Profiling Reveals TL1A as a Biomarker and Driver of Type 2 Inflammation via Macrophage-Dependent Immunoregulation in Asthma. [PDF]

Research (Wash D C)
Zhang J, Liu X, Qi Q, Pan Y, Zeng R, Qiao C, Xu C, Wang P, Shi S, Wang Y, Liu X, Dong L.   +11 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Type 2 inflammation in chronic obstructive pulmonary disease: A promising treatable trait and practice recommendations. [PDF]

Chin Med J Pulm Crit Care Med
Chen Y, Yang T, Zhang J, Chen X, Chen X, Cheng Z, Li Y, Fan X, Han W, He Z, Ma D, Meng Y, Yan J, Yin Y, Zeng H, Zhou Q, Zhou X, Cai H, Cui Y, Ma Y, Wen F, Sun Y, Sun D, Liu X, Zheng J, Wang W, Zheng Z, Yan X, Cai S, Cao J, Song Y, Zhao J, Zhou Y, Zhu H, Li M, Guo Y, Ma Q, Liang Z, Zhao L, Chen Y, Wang J, Wang F, Yang Y, Yang H, Kang J, Chen R, Assembly of Chronic Obstructive Pulmonary Disease (COPD) of Chinese Thoracic Society (CTS), COPD Working Group of Chinese Association of Chest Physician (CACP) of the Chinese Medical Doctor Association, Evidence-Based Medicine Group of the Clinical Epidemiology Branch of the Chinese Medical Association, Respiratory Disease Control Committee of the Chinese Preventive Medicine Association, Precision Medicine Group of the Respiratory Disease Committee of the Cross-Strait Medical and Health Exchange Association.   +50 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Global Airways in Practice: Long-term Effects of Mepolizumab With or Without FESS on Type 2 Inflammation in Patients With CRSwNP. [PDF]

Int Forum Allergy Rhinol
Tidemandsen J, Backer V, Homøe AS, Jensen THL, Aanæs K, Meteran H, Hostrup M, Moesgaard L, Haase C, Gibson PG.   +9 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Burden of COPD with Type 2 Inflammation in North-West Continental Europe. [PDF]

Int J Chron Obstruct Pulmon Dis
Sandelowsky H, Løkke A, Kocks JWH, Grøttum HS, Bakke PS, Vasankari T.   +5 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Impact of Effect Modification of Type 2 Inflammation and Sex on Asthma Exacerbation Rates. [PDF]

CHEST Pulm
Agarwal T, Peterson R, Jimenez G, Taich Z, Sharma S, Holguin F, Althoff MD.   +6 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source