Results 31 to 40 of about 1,471,209 (258)

Pathobiology of Type 2 Inflammation in Asthma and Nasal Polyposis

Journal of Clinical Medicine, 2023
Asthma and nasal polyposis often coexist and are frequently intertwined by tight pathogenic links, mainly consisting of the cellular and molecular pathways underpinning type 2 airway inflammation. The latter is characterized by a structural and functional impairment of the epithelial barrier, associated with the eosinophilic infiltration of both the ...
Corrado Pelaia, Giulia Pelaia, Angelantonio Maglio, Caterina Tinello, Luca Gallelli, Nicola Lombardo, Rosa Terracciano, Alessandro Vatrella   +7 more
openaire   +2 more sources

Secondary Publication: New Aspects of Biologically Active Substances: Atopic Dermatitis

Tokyo Women's Medical University Journal
Atopic dermatitis is characterized by three factors: decreased skin barrier function, type 2 immune response, and itching. In recent years, the elucidation of the pathological condition of atopic dermatitis has progressed from the immunological aspect ...
Yuko Takenaka
doaj   +1 more source

The Role of Type 2 Inflammation in Schistosoma-Induced Pulmonary Hypertension

Frontiers in Immunology, 2019
Approximately 5% of individuals chronically infected with Schistosoma mansoni develop pulmonary hypertension (PH). The disease is progressive and often fatal, and treatment options are palliative, not curative. Recent studies have unraveled major players
Claudia S. Mickael, Brian B. Graham
doaj   +1 more source

Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets

Frontiers in Physiology, 2022
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation, whose incidence is rising.
Francesca Racca, Francesca Racca, Gaia Pellegatta, Giuseppe Cataldo, Edoardo Vespa, Edoardo Vespa, Elisa Carlani, Corrado Pelaia, Giovanni Paoletti, Giovanni Paoletti, Maria Rita Messina, Maria Rita Messina, Emanuele Nappi, Emanuele Nappi, Giorgio Walter Canonica, Giorgio Walter Canonica, Alessandro Repici, Alessandro Repici, Enrico Heffler, Enrico Heffler   +19 more
doaj   +1 more source

Real-World Evaluation of Dupilumab in the Long-Term Management of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps: A Focus on IL-4 and IL-13 Receptor Blockade

Medicina
Background and Objectives: Chronic rhinosinusitis (CRS) is a complex inflammatory condition of the nasal passages that severely impairs quality of life. Type 2 CRS is characterized by eosinophilic inflammation, driven by cytokines like IL-4, IL-5, and IL-
Nicola Lombardo, Aurelio D’Ecclesia, Emanuela Chiarella, Corrado Pelaia, Debbie Riccelli, Annamaria Ruzza, Nadia Lobello, Giovanna Lucia Piazzetta   +7 more
doaj   +1 more source

Tanis: A Link Between Type 2 Diabetes and Inflammation? [PDF]

Diabetes, 2002
Here we describe a novel protein, which we have named Tanis, that is implicated in type 2 diabetes and inflammation. In Psammomys obesus, a unique polygenic animal model of type 2 diabetes and the metabolic syndrome, Tanis is expressed in the liver in inverse proportion to circulating glucose (P = 0.010) and insulin levels (P = 0.004) and in direct ...
Walder, Ken, Kantham, Lakshmi, McMillan, Janine S, Trevaskis, James, Kerr, Lyndal, De Silva, Andrea, Sunderland, Terry, Godde, Nathan, Gao, Yuan, Bishara, Natalie, Windmill, Kelly, Tenne-Brown, Janette, Augert, Guy, Zimmet, Paul Z, Collier, Greg R   +14 more
openaire   +4 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

352 Macrophage regulation of inflammation in type 2 diabetes

Journal of Clinical and Translational Science
Objectives/Goals: Type 2 diabetes is a metabolic disease characterized by non-resolving inflammation. Our objective is to investigate how macrophages contribute to this dysregulation.
Tanvi Banota, Valerie Horsley, Kathryn Miller-Jensen   +2 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source