Results 31 to 40 of about 102,290,503 (289)

Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]

, 2011
p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Iversen, Lars, A Funding, JS Arthur, Johansen, Claus, Kragballe, Knud, BM Bibby, Lilleholt, Louise Langer, Funding, Anne, L Iversen, Bibby, Bo Martin, K Kragballe, C Johansen, Arthur, J. Simon C.; id_orcid, LL Lilleholt   +13 more
core   +1 more source

High-fat diet and palmitic acid amplify airway type 2 inflammation

Frontiers in Allergy, 2023
IntroductionMetabolic dysfunction such as elevated levels of saturated fatty acids (SFA) may play a role in obese asthma, but its contribution to airway inflammation remains unclear.
Kris Genelyn Dimasuay, Bruce Berg, Niccolette Schaunaman, Fernando Holguin, Daniel Winnica, Hong Wei Chu   +5 more
doaj   +1 more source

Some mechanisms of inflammation development in type 2 diabetes mellitus

Сахарный диабет, 2021
Inflammation plays a key role in the development and progression of type 2 diabetes (T2DM), a disease characterized by peripheral insulin resistance and systemic glucolipotoxicity.
L. A. Bochkareva, L. V. Nedosugova, N. A. Petunina, M. Е. Теlnova, E. V. Goncharova   +4 more
doaj   +1 more source

Periostin activates distinct modules of inflammation and itching downstream of the type 2 inflammation pathway

, 2023
Atopic dermatitis (AD) is a chronic relapsing skin disease accompanied by recurrent itching. Although type 2 inflammation is dominant in allergic skin inflammation, it is not fully understood how non-type 2 inflammation co-exists with type 2 inflammation
Naoko Ejiri, Yamamoto, Sayaka, Nanri, Yasuhiro, Hitoshi Ikemitsu, Hironobu Takedomi, Misaki Koga, Ikemitsu, Hitoshi, Andoh, Tsugunobu, Kitajima, Isao, Takedomi, Hironobu, Sayaka Yamamoto, Yuko Honda, Tsugunobu Andoh, Kenji Izuhara, Kosuke Matsuda, Satoshi Nunomura, Daisuke Uta, Yasuhiro Nanri, Midori Kitajima, Matsuda, Kosuke, Kitajima, Midori, Nunomura, Satoshi, Uta, Daisuke, Conway, Simon J., Izuhara, Kenji, Simon J. Conway, Koga, Misaki, Honda, Yuko, Isao Kitajima, Ejiri, Naoko   +29 more
core   +1 more source

Strategies Targeting Type 2 Inflammation: From Monoclonal Antibodies to JAK-Inhibitors

Biomedicines, 2021
Bronchial asthma and its frequent comorbidity chronic rhinosinusitis (CRS), are characterized by an inflammatory process at lower and upper respiratory tract, with a variability in terms of clinical presentations (phenotypes) and distinct underpin ...
Andrea Matucci, Emanuele Vivarelli, Francesca Nencini, Enrico Maggi, Alessandra Vultaggio   +4 more
doaj   +1 more source

The role of childhood social position in adult type 2 diabetes: evidence from the English longitudinal study of ageing [PDF]

, 2014
Background: socioeconomic circumstances in childhood and early adulthood may influence the later onset of chronic disease, although such research is limited for type 2 diabetes and its risk factors at the different stages of life.
Pikhartova, J., Blane, David, Netuveli, G, Blane, D, Gopalakrishnan Netuveli, David Blane, Netuveli, Gopalakrishnan, Jitka Pikhartova, Pikhartova, J   +8 more
core   +2 more sources

Inflammation and the Incidence of Type 2 Diabetes [PDF]

Diabetes Care, 2010
OBJECTIVE Many studies have documented associations between inflammation and type 2 diabetes incidence. We assessed potential variability in this association in the major U.S. racial/ethnic groups. RESEARCH DESIGN AND METHODS Incident ...
Bertoni, Alain G., Burke, Gregory L., Owusu, James A., Carnethon, Mercedes R., Vaidya, Dhananjay, Barr, R. Graham, Jenny, Nancy S., Ouyang, Pamela, Rotter, Jerome I.   +8 more
openaire   +2 more sources

Effects of probiotics in patients with diabetes mellitus type 2 : study protocol for a randomized, double-blind, placebo-controlled trial [PDF]

, 2013
Background: Low grade chronic inflammation is observed in patients with type 2 diabetes mellitus (T2DM). Endotoxin derived from gut bacteria may act as a potent inflammatory stimulant.
Majed S Alokail, Sabico, S, Yousef Al-Saleh, Sabico, Shaun, McTernan, PG, Alokail, MS, Nasser M Al-Daghri, Vanhoutte, Paul M., Alokail, Majed S., Al-Daghri, NM, Shaun Sabico, Alkharfy, KM, Vanhoutte, PMGR, Philip G McTernan, Al-Saleh, Yousef, Al-Daghri, Nasser M., Al-Saleh, Y, Alkharfy, Khalid M., McTernan, P. G. (Philip G.), Khalid M Alkharfy, Paul M Vanhoutte   +20 more
core   +1 more source

Sex Differences in IL-33-Induced STAT6-Dependent Type 2 Airway Inflammation

Frontiers in Immunology, 2019
Sex differences in asthma prevalence are well-documented but poorly understood. Murine models have contributed to our understanding of mechanisms that could regulate this sex disparity, though the majority of these studies have examined responses present
Hedi Zhao, Vanessa Moarbes, Véronique Gaudreault, Jichuan Shan, Haya Aldossary, Louis Cyr, Elizabeth D. Fixman   +6 more
doaj   +1 more source

RAGE-mediated inflammation, type 2 diabetes and diabetic vascular complication

Frontiers in Endocrinology, 2013
Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions.
Yasuhiko eYamamoto, Hiroshi eYamamoto
doaj   +1 more source