Journal of Lipid Research, 2019 Eicosanoids are lipid-mediator molecules with key roles in inflammatory skin diseases, such as psoriasis. Eicosanoids are released close to the source of inflammation, where they elicit local pleiotropic effects and dysregulations.
Cornelia Pipper +8 more
doaj +1 more source
CCL4 Functions as a Biomarker of Type 2 Airway Inflammation
Biomedicines, 2022 Eosinophilic airway inflammatory disease is associated with bronchial asthma, with eosinophilic chronic rhinosinusitis (ECRS) typical of refractory type 2 airway inflammation.
Yoshiki Kobayashi +9 more
doaj +1 more source
Lung Function and Risk of Type 2 Diabetes and Fatal and Nonfatal Major Coronary Heart Disease Events: Possible Associations With Inflammation [PDF]
, 2010 OBJECTIVE - We prospectively examined the relationship between lung function and risk of type-2 diabetes and fatal and nonfatal coronary heart disease (CHD) events and investigated the hypothesis that inflammation may underlie these associations ...
Lowe, G.D. +20 more
core +1 more source
Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population [PDF]
, 2005 Aims Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease.
N Al-Daghri +19 more
core +1 more source
Islet inflammation in type 2 diabetes and physiology [PDF]
Journal of Clinical Investigation, 2017 The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell dysfunction has further highlighted the significance of inflammation in metabolic diseases. The number of intra-islet macrophages is increased in T2D, and these cells are the main source of proinflammatory cytokines within islets. Multiple human studies of T2D have
Kosei, Eguchi, Ryozo, Nagai
openaire +2 more sources
Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy [PDF]
, 2014 Helminth parasites such as the nematode Heligmosomoides polygyrus strongly inhibit T helper type 2 (Th2) allergy, as well as colitis and autoimmunity. Here, we show that the soluble excretory/secretory products of H.
McSorley, H. J.; id_orcid +15 more
core +1 more source
Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system [PDF]
, 2011 The intestinal immune system and the epithelium are the first line of defense in the gut. Constantly exposed to microorganisms from the environment, the gut has complex defense mechanisms to prevent infections, as well as regulatory pathways to tolerate ...
Anna Vossenkämper +5 more
core +1 more source
Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis
Frontiers in Immunology, 2021 Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases.
Chong Deng +9 more
doaj +1 more source
Role of type 2 immunity in intestinal inflammation [PDF]
Current Opinion in Gastroenterology, 2015 Type 2 (Th2) immune responses play important roles in intestinal immunity by contributing to the maintenance of mucosal homeostasis, not only conferring protection against helminthic infection but also participating in pro-inflammatory pathways in chronic intestinal inflammatory disorders, including inflammatory bowel disease.
Bamias, G., Cominelli, F.
openaire +3 more sources
The role of childhood social position in adult type 2 diabetes: evidence from the English longitudinal study of ageing [PDF]
, 2014 Background: socioeconomic circumstances in childhood and early adulthood may influence the later onset of chronic disease, although such research is limited for type 2 diabetes and its risk factors at the different stages of life.
Pikhartova, J. +8 more
core +2 more sources