Results 21 to 30 of about 102,290,503 (289)

Induction of sterile type 2 inflammation [PDF]

Nature Materials, 2019
Microparticle debris from prosthetic implants has been shown to induce a type 2 inflammatory response through a Bruton’s tyrosine kinase-dependent signalling pathway.
Dimitri A, de Kouchkovsky, Sourav, Ghosh, Carla V, Rothlin   +2 more
openaire   +2 more sources

Inflammation and the etiology of type 2 diabetes [PDF]

Diabetes/Metabolism Research and Reviews, 2005
AbstractType 2 diabetes is increasingly common worldwide and is beginning to strike younger age groups. Almost 90% of all patients with diabetes show insulin resistance, which also precedes the first symptoms of diabetes. The mechanisms underlying the development of insulin resistance are not well understood.
Ake, Sjöholm, Thomas, Nyström
openaire   +2 more sources

Lung Function and Risk of Type 2 Diabetes and Fatal and Nonfatal Major Coronary Heart Disease Events: Possible Associations With Inflammation [PDF]

, 2010
OBJECTIVE - We prospectively examined the relationship between lung function and risk of type-2 diabetes and fatal and nonfatal coronary heart disease (CHD) events and investigated the hypothesis that inflammation may underlie these associations ...
Lowe, G.D., Lowe, GD, Wannamethee, S. G., Whincup, PH, Sattar, N, Sattar, N., Thomas, MC, Peter H. Whincup, Rumley, A., Ann Rumley, Naveed Sattar, A. Gerald Shaper, S. Goya Wannamethee, Shaper, AG, Gordon D. Lowe, Rumley, A, Whincup, P. H., Mary C. Thomas, Wannamethee, SG, Shaper, A. G., Thomas, M. C.   +20 more
core   +1 more source

CCL4 Functions as a Biomarker of Type 2 Airway Inflammation

Biomedicines, 2022
Eosinophilic airway inflammatory disease is associated with bronchial asthma, with eosinophilic chronic rhinosinusitis (ECRS) typical of refractory type 2 airway inflammation.
Yoshiki Kobayashi, Hanh Hong Chu, Akira Kanda, Yasutaka Yun, Masami Shimono, Linh Manh Nguyen, Akitoshi Mitani, Kensuke Suzuki, Mikiya Asako, Hiroshi Iwai   +9 more
doaj   +1 more source

Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population [PDF]

, 2005
Aims Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease.
N Al-Daghri, R Chetty, Al-Rubean, K., McTernan, P.G, Al-Attas, O., Kumar, Sudhesh, K Al-Rubean, Al-Daghri, N., Jones, A.F., Chetty, R., Al-Rubean , K., Al-Attas, Omar S., Al-Daghri, Nasser M., PG McTernan, O Al-Attas, Kumar, S., McTernan, P. G. (Philip G.), AF Jones, Jones, A. F., S Kumar   +19 more
core   +1 more source

Islet inflammation in type 2 diabetes and physiology [PDF]

Journal of Clinical Investigation, 2017
The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell dysfunction has further highlighted the significance of inflammation in metabolic diseases. The number of intra-islet macrophages is increased in T2D, and these cells are the main source of proinflammatory cytokines within islets. Multiple human studies of T2D have
Kosei, Eguchi, Ryozo, Nagai
openaire   +2 more sources

Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy [PDF]

, 2014
Helminth parasites such as the nematode Heligmosomoides polygyrus strongly inhibit T helper type 2 (Th2) allergy, as well as colitis and autoimmunity. Here, we show that the soluble excretory/secretory products of H.
McSorley, H. J.; id_orcid, Smith, K A, Blair, N.F., McSorley, H J, McSorley, H.J., Maizels, R M, McSorley, H. J., Smith, K. A., Smith, K.A., Maizels, R. M., Blair, N F, McKenzie, A.N.J., Blair, N. F., McKenzie, A N J, Maizels, R.M., McKenzie, A. N. J.   +15 more
core   +1 more source

Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system [PDF]

, 2011
The intestinal immune system and the epithelium are the first line of defense in the gut. Constantly exposed to microorganisms from the environment, the gut has complex defense mechanisms to prevent infections, as well as regulatory pathways to tolerate ...
Anna Vossenkämper, Thomas T MacDonald, Marches, O, Vossenkamper, A, Olivier Marchès, MacDonald, TT   +5 more
core   +1 more source

Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis

Frontiers in Immunology, 2021
Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases.
Chong Deng, Na Peng, Yuan Tang, Na Yu, Cuicui Wang, Xiaoyan Cai, Lijun Zhang, Dajun Hu, Francesco Ciccia, Liwei Lu   +9 more
doaj   +1 more source

Role of type 2 immunity in intestinal inflammation [PDF]

Current Opinion in Gastroenterology, 2015
Type 2 (Th2) immune responses play important roles in intestinal immunity by contributing to the maintenance of mucosal homeostasis, not only conferring protection against helminthic infection but also participating in pro-inflammatory pathways in chronic intestinal inflammatory disorders, including inflammatory bowel disease.
Bamias, G., Cominelli, F.
openaire   +3 more sources