Results 11 to 20 of about 1,471,209 (258)
Contributions of innate type 2 inflammation to adipose function [PDF]
Journal of Lipid Research, 2019 A critical contributor to the health consequences of the obesity epidemic is dysregulated adipose tissue (AT) homeostasis. While white, brown, and beige AT function is altered in obesity-related disease, white AT is marked by progressive inflammation and
W. Reid Bolus, Alyssa H. Hasty
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Biomarkers of type 2 and non-type 2 inflammation in asthma exacerbations
Central European Journal of ImmunologyIntroduction In adult-onset asthma, two major endotypes have been proposed: T2 with eosinophilia and non-T2 characterised by neutrophils and interleukin (IL)-17. The objective of the study was to examine the endotype marker profile in patients with severe asthma who were hospitalized for exacerbations, with a ...
Kosar M. Ali +6 more
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Islet inflammation in type 2 diabetes [PDF]
Seminars in Immunopathology, 2019 Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell failure is a major component of the pathogenesis of type 2 diabetes. It is now well established that increased numbers of innate immune cells, cytokines, and chemokines have detrimental effects on islets in these chronic conditions.
Böni-Schnetzler M, Meier DT
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Induction of sterile type 2 inflammation [PDF]
Nature Materials, 2019 Microparticle debris from prosthetic implants has been shown to induce a type 2 inflammatory response through a Bruton’s tyrosine kinase-dependent signalling pathway.
Dimitri A, de Kouchkovsky +2 more
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Inflammation and the etiology of type 2 diabetes [PDF]
Diabetes/Metabolism Research and Reviews, 2005 AbstractType 2 diabetes is increasingly common worldwide and is beginning to strike younger age groups. Almost 90% of all patients with diabetes show insulin resistance, which also precedes the first symptoms of diabetes. The mechanisms underlying the development of insulin resistance are not well understood.
Ake, Sjöholm, Thomas, Nyström
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Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis
Frontiers in Immunology, 2021 Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases.
Chong Deng +9 more
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Examining the Role of Type 2 Inflammation in Eosinophilic Esophagitis
Gastro Hep Advances, 2022 Eosinophilic esophagitis (EoE) is a chronic type 2 inflammatory disease characterized by an eosinophilic inflammatory infiltrate in the esophagus, leading to remodeling, stricture formation, and fibrosis.
Mirna Chehade +11 more
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Islet inflammation in type 2 diabetes and physiology [PDF]
Journal of Clinical Investigation, 2017 The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell dysfunction has further highlighted the significance of inflammation in metabolic diseases. The number of intra-islet macrophages is increased in T2D, and these cells are the main source of proinflammatory cytokines within islets. Multiple human studies of T2D have
Kosei, Eguchi, Ryozo, Nagai
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High-fat diet and palmitic acid amplify airway type 2 inflammation
Frontiers in Allergy, 2023 IntroductionMetabolic dysfunction such as elevated levels of saturated fatty acids (SFA) may play a role in obese asthma, but its contribution to airway inflammation remains unclear.
Kris Genelyn Dimasuay +5 more
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Some mechanisms of inflammation development in type 2 diabetes mellitus
Сахарный диабет, 2021 Inflammation plays a key role in the development and progression of type 2 diabetes (T2DM), a disease characterized by peripheral insulin resistance and systemic glucolipotoxicity.
L. A. Bochkareva +4 more
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