Results 71 to 80 of about 232,266 (302)

Unveiling Palmitoyl Thymidine Derivatives as Antimicrobial/Antiviral Inhibitors: Synthesis, Molecular Docking, Dynamic Simulations, ADMET, and Assessment of Protein–Ligand Interactions

Pharmaceuticals
Background/Objectives: Nucleoside precursors and derivatives play pivotal roles in the development of antimicrobial and antiviral therapeutics. The 2022 global outbreak of monkeypox (Mpox) across more than 100 nonendemic countries underscores the urgent ...
Sarkar M. A. Kawsar, Samiah Hamad Al-mijalli, Gassoumi Bouzid, Emad M. Abdallah, Noimul H. Siddiquee, Mohammed A. Hosen, Mabrouk Horchani, Houcine Ghalla, Hichem B. Jannet, Yuki Fujii, Yasuhiro Ozeki   +10 more
doaj   +1 more source

Magnetic DNA Origami Nanorotors

Advanced Materials, EarlyView.
Magnetic actuation is a powerful and broadly applicable actuation mechanism due to its programmability and compatibility with biological entities. Here we demonstrate magnetic DNA origami nanorotors (MADONAs) by assembling magnetic nanocubes on DNA origami.
Lennart J. K. Weiß, Florian Rothfischer, Yihao Wang, Christoph Pauer, Xin Yin, Kevin Lang, Rabia Amin, Thomas Tsalos, Susanne Kempter, Jan Lipfert, Tim Liedl, Friedrich C. Simmel, Joe Tavacoli, Aidin Lak   +13 more
wiley   +1 more source

Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases [PDF]

, 2003
Crystal structures of equine herpesvirus type-4 thymidine kinase (EHV4-TK) in complex with (i) thymidine and ADP, (ii) thymidine and SO4 and the bisubstrate analogs, (iii) TP4A, and (iv) TP5A have been solved.
Shuvalova, L., Konrad, M., Shuvalova, Ludmilla, Monnerjahn, Christian, Lavie, Arnon, Gardberg, A., Konrad, Manfred, Lavie, A., Monnerjahn, C., Gardberg, Anna   +9 more
core   +2 more sources

Mitochondrial Neurogastrointestinal Encephalomyopathy Treated with Stem Cell Transplantation: A Case Report and Review of Literature

Hematology/Oncology and Stem Cell Therapy, 2015
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder. The mutation in the ECGF1 gene causes severe deficiency of thymidine phosphorylase (TP), which in turn increases thymidine and deoxyuridine in the blood,
Musthafa Chalikandy Peedikayil, Eje Ingvar Kagevi, Ehab Abufarhaneh, Moeenaldeen Dia Alsayed, Hazzaa Abdulla Alzahrani   +4 more
doaj   +1 more source

Pharmacogenetic variation influences sensory neuropathy occurrence in Southern Africans treated with stavudine-containing antiretroviral therapy. [PDF]

PLoS ONE, 2018
BACKGROUND:The use of the HIV antiretroviral drug stavudine (d4T), a thymidine analogue, is associated with the development of mitochondrial toxicities such as sensory neuropathy (SN).
Marvin Blessings Moketla, Antonia L Wadley, Peter Kamerman, Debra de Assis Rosa   +3 more
doaj   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography [PDF]

, 2003
Background and aims: Positron emission tomography (PET) using 18F labelled 2-fluoro-2-deoxy-D-glucose (18FDG) is an established imaging tool, although the recent development of a biologically stable thymidine analogue [18F] 3'-deoxy-3-fluorothymidine ...
Costa, D.C., Ell, P.J., Luthra, S.K., Taylor, I., Francis, D.L., Freeman, A., Novelli, M., Visvikis, D.   +7 more
core  

Overproduction of thymidine by recombinant Brevibacterium helvolum amplified with thymidine monophosphate phosphohydrolase gene from bacteriophage PBS2 [PDF]

, 2004
A microbial fermentation process could be used to produce thymidine biologically but many of the enzymes related to nucleotide biosynthesis are highly regulated.
Sang Nam Lee, Hyeon Cheol Lee, Kim, Jung Hoe, Jung Mi Ahn   +3 more
core   +1 more source

The structural basis of unique substrate recognition by Plasmodium thymidylate kinase: Molecular dynamics simulation and inhibitory studies.

PLoS ONE, 2019
Plasmodium falciparum thymidylate kinase (PfTMK) showed structural and catalytic distinctions from the host enzyme rendering it a hopeful antiprotozoal drug target.
Mahmoud Kandeel, Yukio Kitade, Abdulla Al-Taher, Mohammed Al-Nazawi   +3 more
doaj   +1 more source

Transcriptional profiling of thymidine-producing strain recombineered from Escherichia coli BL21

Genomics Data, 2015
DNA microarrays were used to compare the expression profiles of a thymidine overproducing strain (BLT013) and its isogenic parent, Escherichia coli BL21(DE3), when each was grown under well-defined thymidine production conditions with glycerol as carbon ...
Jin-Sook Kim, Bong-Seong Koo, Hyeon-Cheol Lee   +2 more
doaj   +1 more source