Results 81 to 90 of about 151,356 (287)

TYMP (thymidine phosphorylase) [PDF]

, 2010
Review on TYMP (thymidine phosphorylase), with data on DNA, on the protein encoded, and where the gene is ...
Bijnsdorp, IV, GJ Peters, IV Bijnsdorp, Peters, GJ   +3 more
core   +1 more source

DNA Nanoarray for Multiplexed RNA Detection With Single‐Molecule Readout

Advanced Science, EarlyView.
A carrier‐based DNA nanoarray integrates programmable nucleic acid hybridization with solid‐state nanopore readout for direct RNA detection at single‐molecule resolution. A ternary encoding system enables 27 carriers with 81 addressable sensing sites, allowing the simultaneous identification of targets spanning a wide size range, from short microRNAs ...
Yunxuan Li, Yesheng Wang, Chunmiao Yu, Siyu Hou, Elli Mylona, Plamena Naydenova, Jingyuan Zhao, Hong Yuan, Jingsong Duan, Hendrik F. P. Runge, Stephen Baker, Jinbo Zhu, Ulrich F. Keyser   +12 more
wiley   +1 more source

Limits of [18F]-FLT PET as a biomarker of proliferation in oncology. [PDF]

PLoS ONE, 2013
Non-invasive imaging biomarkers of cellular proliferation hold great promise for quantifying response to personalized medicine in oncology. An emerging approach to assess tumor proliferation utilizes the positron emission tomography (PET) tracer 3'-deoxy-
Eliot T McKinley, Gregory D Ayers, R Adam Smith, Samir A Saleh, Ping Zhao, Mary Kay Washington, Robert J Coffey, H Charles Manning   +7 more
doaj   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Comparison of thymidine phosphorylase expression and prognostic factors in gallbladder and bile duct cancer

BMC Cancer, 2010
Background Biliary tract cancers have limitations in information about different location-related pathogenesis and clinico-pathological characteristics.
You Young, Kim Dong-Goo, Chung Eun-Seon, Lee Myung, Won Hye, Hong Tae, Lee In-Seok   +6 more
doaj   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Laser flash photolysis and magnetic-field-effect studies on interaction of thymine and thymidine with menadione: role of sugar in controlling reaction pattern

Science and Technology of Advanced Materials, 2008
The magnetic field effect (MFE) in conjunction with laser flash photolysis has been used for the study of the interaction of one of the small drug like quinone molecules, 2-methyl, 1,4-naphthoquinone, commonly known as menadione (MQ), with one of the DNA
Adity Bose, Debarati Dey and Samita Basu
doaj  

Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions

Cardiovascular Diabetology, 2007
Background Inhibition of vascular smooth muscle cell (vSMC) proliferation by oral anti-hyperglycemic agents may have a role to play in the amelioration of vascular disease in diabetes.
de Dios Stephanie T, Osman Narin, Little Peter J, Cemerlang Nelly, Ballinger Mandy, Nigro Julie   +5 more
doaj   +1 more source

Kinetic Analysis of 2-[C]Thymidine PET Imaging Studies of Malignant Brain Tumors: Compartmental Model Investigation and Mathematical Analysis

Molecular Imaging, 2002
2-[ 11 C]Thymidine (TdR), a PET tracer for cellular proliferation, may be advantageous for monitoring brain tumor progression and response to therapy. We previously described and validated a five-compartment model for thymidine incorporation into DNA in ...
Joanne M. Wells, David A. Mankoff, Mark Muzi, Finbarr O'Sullivan, Janet F. Eary, Alexander M. Spence, Kenneth A. Krohn   +6 more
doaj   +1 more source

20-HETE inhibits the proliferation of vascular smooth muscle cells via transforming growth factor-β

Journal of Lipid Research, 2008
20-Hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 arachidonic acid metabolite, has been shown to modulate the growth of vascular smooth muscle cells (VSMCs).
Chan-Jung Liang, Harlan E. Ives, Chuen-Mao Yang, Yunn-Hwa Ma   +3 more
doaj   +1 more source