Results 61 to 70 of about 232,266 (302)

Thymidine Phosphorylation in Wheat [PDF]

Plant Physiology, 1978
Extracts of wheat (Triticum vulgare Vill. [Triticum aestivum L.] var. Lemhi) seedlings contain thymidine-phosphorylating activity with ATP, ADP, or AMP and nucleotide hydrolase activity (ATP --> --> AMP). The synthesis of [(32)P]dTMP exclusively from [alpha-(32)P]ATP with none detectable from [gamma-(32)P]ATP demonstrates the absence of thymidine ...
J, Hofman, O J, Schwarz
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Mitochondrial neurogastrointestinal encephalomyopathy: Clinical and biochemical impact of allogeneic stem cell transplantation in a Greek patient with one novel TYMP mutation

Molecular Genetics and Metabolism Reports, 2022
We describe the case of a Greek female patient with the Classic form of the ultra- rare and fatal autosomal recessive disorder Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) and the impact of allogeneic hematopoietic stem cell ...
A. Paisiou, M. Rogalidou, R. Pons, E. Ioannidou, K. Dimakou, A. Papadopoulou, F.M. Vaz, G. Vessalas, S.M.I. Goorden, J. Roelofsen, A. Zoetekouw, M.M. Nieman, E. Dimitriou, M. Moraitou, I. Peristeri, H. Michelakakis, A.B.P. van Kuilenburg   +16 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Clinicopathological Significance of Thymidine Phosphorylase Expressed in Node-Negative Breast Cancer Tumors [PDF]

, 2001
The expression of thymidine phosphorylase (dThd Pase) in node-negative human invasive ductal carcinoma tissues was investigated by the immunocytochemical method using anti-thymidine phosphorylase monoclonal antibody.Subjects were 5 recurrent and 30 non ...
土屋, 眞一, 麻沼, 和彦, 本原, 昭子, 丸山, 正幸, 藤森, 実, 草間, 律, 天野, 純, 浜, 善久   +7 more
core  

N3-Substituted thymidine analogues V: Synthesis and preliminary PET imaging of N3-[18F]fluoroethyl thymidine and N3-[18F]fluoropropyl thymidine [PDF]

, 2008
Introduction: [18F]-Labeled analogues of thymidine have demonstrated efficacy for PET imaging of cellular proliferation. We have synthesized two [18F]-labeled N3-substituted thymidine analogues, N3-[18F]fluoroethyl thymidine (N3-[18F]-FET) and N3-[18F ...
Yeh, Hsin Hsien, Flores, Leo G., Alauddin, Mian M., Gelovani, Juri G., Soghomonyan, Suren, Shavrin, Aleksandr, Volgin, Andrei Y., Mukhopadhyay, Uday   +7 more
core   +1 more source

Local Treatment of Hand-Foot Syndrome with Uridine/Thymidine: In Vitro Appraisal on a Human Keratinocyte Cell Line HaCaT

The Scientific World Journal, 2012
5-fluorouracil (5-FU) is one of the most commonly used antineoplastic drugs in the anticancer therapy. The hand-foot (HF) syndrome (palmar-plantar erythrodysesthesia) is an adverse effect frequently related to long-term i.v. administration of 5-FU or its
J. Hartinger, P. Veselý, E. Matoušková, S. Argalacsová, L. Petruželka, I. Netíková   +5 more
doaj   +1 more source

Thymidine Analogues for Tracking DNA Synthesis

Molecules, 2011
Replicating cells undergo DNA synthesis in the highly regulated, S-phase of the cell cycle. Analogues of the pyrimidine deoxynucleoside thymidine may be inserted into replicating DNA, effectively tagging dividing cells allowing their characterisation ...
B. Cavanagh, Tom Walker, Anwar Norazit, A. Meedeniya   +3 more
semanticscholar   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Inhibition of phosphorylation and incorporation of thymidine in duckweed (Lemna minor L.) by sulfur dioxide and sulfite [PDF]

, 1975
As there appears to be no thymidine kinase in duckweed (Lemna minor L.), thymidine seems to be phosphorylated by a nucleoside phosphotransferase. Phosphorylation and incorporation are inhibited by sulfur compounds such as sulfur dioxide and sulfite.
Erismann, Karl Hans, Brändle, Roland, Stöckli, B.   +2 more
core   +1 more source