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[Thymidine kinase (author's transl)].

Postepy biochemii, 1976
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The thymidine phosphorylating kinases

Biochimica et Biophysica Acta, 1961
Abstract The pattern of the phosphorylation reactions when supernatant fractions from leukaemic spleen and lymph nodes of mice are incubated with an ATP regenerating system and [2- 14 C]thymidine has been studied. The results indicate that TDP is not an intermediate in the formation of TTP, the latter compound being formed by pyrophosphate addition ...
P A, BIANCHI, J A, BUTLER, A R, CRATHORN, K V, SHOOTER   +3 more
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Mitochondrial-specific thymidine kinase

Archives of Biochemistry and Biophysics, 1973
Abstract Thymidine kinase activity has been demonstrated in purified mitochondria prepared from animal tissue, wild-type tissue culture cells, and BrdU-resistant cell lines. The BrdU-resistant cell lines lack a soluble cytoplasmic thymidine kinase present in wild-type cells, but continue to exhibit the minor mitochondrial activity.
A J, Berk, B J, Meyer, D A, Clayton
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Mitochondrial Thymidine Kinase Inhibitors

Current Topics in Medicinal Chemistry, 2005
Mitochondrial thymidine kinase or TK-2 belongs to the family of mammalian deoxynucleoside kinases (dNKs) that catalyze the phosphorylation of deoxynucleosides to their corresponding deoxynucleoside monophosphates by gamma-phosphoryl transfer of ATP.
María-Jesús, Pérez-Pérez, Ana-Isabel, Hernández, Eva-María, Priego, Fátima, Rodríguez-Barrios, Federico, Gago, María-José, Camarasa, Jan, Balzarini   +6 more
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Thymidine Kinases in Archaea

Nucleosides, Nucleotides and Nucleic Acids, 2006
Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum.
A R, Clausen, A, Matakos, M P B, Sandrini, J, Piskur   +3 more
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Methotrexate decreases thymidine kinase activity

Biochemical and Biophysical Research Communications, 1992
MTX cytotoxicity is not fully explained by its well-known inhibition of dihydrofolate reductase activity which leads to a decrease in the dTMP synthase reaction, since TdR kinase which converts TdR to dTMP could readily circumvent MTX action through this salvage activity.
M, Abonyi, N, Prajda, Y, Hata, H, Nakamura, G, Weber   +4 more
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Thymidine Kinase in Megaloblastic Anaemia

British Journal of Haematology, 1976
Summary. Thymidine kinase has been measured in phytohaemagglutinin (PHA)‐stimulated lymphocytes from 13 normal subjects and eight patients with megaloblastic anaemia. The levels in normal subjects ranged from 0.20 to 2.10 units/mg protein (mean 0.903 units/mg protein) and in megaloblastic anaemia from 2.99 to 9.97 units/mg protein (mean 5.76 units/mg ...
J W, Hooton, A V, Hoffbrand
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Thymidine kinase and cancer monitoring

Cancer Letters, 2012
Thymidine kinases (TK) have a key function in the synthesis of DNA. Two isoenzymes have been characterized: TK1 is cell cycle-dependent and present in the cytoplasm whereas TK2--located in mitochondria--is cell cycle-independent. The diagnostic and prognostic role of TK1 has recently been investigated.
Stefan, Aufderklamm, Tilman, Todenhöfer, Georgios, Gakis, Stephan, Kruck, Joerg, Hennenlotter, Arnulf, Stenzl, Christian, Schwentner   +6 more
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Feedback inhibition of thymidine kinase by thymidine triphosphate

Experimental Cell Research, 1963
THE search for rate-controlling enzyme systems in the overall synthesis of DNA has led a number of investigators to study the reactions in the sequence from Tdr to dTTP. Little duplication of effort has occurred despite the similarity in overall objectives.
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Thymidine Kinase Diversity in Bacteria

Nucleosides, Nucleotides and Nucleic Acids, 2006
Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related
M P B, Sandrini, A R, Clausen, B, Munch-Petersen, J, Piskur   +3 more
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