Results 241 to 250 of about 116,563 (263)
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Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases
Virology, 1987The thymidine kinase (TK) gene of fowlpox virus (FPV) is located in a 2.2-kb HindIII-ClaI fragment derived from a 5.5-kb EcoR1 fragment of the FPV genome. The TK gene was mapped to the region of a 700-bp XbaI fragment contained within this HindIII-ClaI fragment.
D B, Boyle +4 more
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1998
The expression of thymidine kinase—an enzyme of the DNA precursor pathway—is strictly regulated during the normal cellular cycle, but is much higher and permanently expressed in malignant growing cells. Using a new cytofluorometric assay for thymidine kinase in single cells, we were able to discriminate between normal growing cells and virally ...
Markus Hengstschläger +2 more
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The expression of thymidine kinase—an enzyme of the DNA precursor pathway—is strictly regulated during the normal cellular cycle, but is much higher and permanently expressed in malignant growing cells. Using a new cytofluorometric assay for thymidine kinase in single cells, we were able to discriminate between normal growing cells and virally ...
Markus Hengstschläger +2 more
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Thymidine kinase assay in canine lymphoma
Veterinary and Comparative Oncology, 2011The aim of the study was to evaluate if thymidine kinase (TK) correlated with duration of first remission (DFR) or survival in dogs with lymphoma and if initial TK levels correlated with stage and substage; and also to assess if TK level at diagnosis correlated with immunophenotype.
J W, Elliott, P, Cripps, L, Blackwood
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Thymidine kinase: diagnostic and prognostic potential
Expert Review of Molecular Diagnostics, 2001Thymidine kinase is a cell cycle-dependent marker that can be detected in the serum of patients diagnosed with many different types of cancer. Serum levels of thymidine kinase have also been shown to reflect the progression of cancer as well as an indication of the efficacy of chemotherapeutic intervention. A new monoclonal antibody assay for thymidine
K L, O'Neill +2 more
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1991
Deoxynucleoside kinases catalyze 5′-phosphorylation of deoxynucleosides and deoxynucleoside analogs used in chemotherapy. Cytosolic thymidine kinase (TK1), mitochondrial thymidine kinase (TK2) and cytosolic deoxycytidine kinase (dCK) are key enzymes in this metabolism.
S, Eriksson +3 more
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Deoxynucleoside kinases catalyze 5′-phosphorylation of deoxynucleosides and deoxynucleoside analogs used in chemotherapy. Cytosolic thymidine kinase (TK1), mitochondrial thymidine kinase (TK2) and cytosolic deoxycytidine kinase (dCK) are key enzymes in this metabolism.
S, Eriksson +3 more
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Serum thymidine kinase in colorectal neoplasia
European Journal of Surgical Oncology (EJSO), 1995Thymidine kinase (TK), an enzyme known to be associated with DNA synthesis, has been measured in the serum of patients with asymptomatic colorectal adenomas (n = 40), asymptomatic colorectal carcinoma (n = 21) and patients known to have hepatic metastases form colorectal tumours (n = 33); enzyme levels have been compared with an age-matched group of ...
W M, Thomas +5 more
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Thymidine kinase in brain-tumor cysts
Journal of Neurosurgery, 1985✓ A recently developed method for deoxythymidine kinase (TK) determination was applied to brain-tumor cyst fluid and fluid from a non-neoplastic intracerebral cyst. The fluid from all tumors tested positive for TK whereas the non-neoplastic cyst lacked TK. Cyst fluid was also analyzed for TK before and after intracystic instillation of BCNU.
L, Persson +4 more
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Epstein-Barr virus-associated thymidine kinase
Journal of Virology, 1978Superinfection of Raji cells with Epstein-Barr virus induced a new thymidine kinase that was distinguishable from both adult and fetal kinases of the host cell by discontinuous electrophoresis on polyacrylamide gels and glycerol gradients.
S T, Chen +3 more
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Thymidine kinase, DNA synthesis and cancer
Molecular and Cellular Biochemistry, 1976A resume has been presented of some recent investigations which show that DNA synthesis can be initiated in many types of quiescent animal cells by external stimuli, by introducing a quiescent nucleus into the cytoplasm of a proliferating cell, or by a virus infection. The components of the DNA replication apparatus are described.
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