Results 201 to 210 of about 102,224 (277)

A phase 1 study of the pharmacokinetics of nucleoside analog trifluridine and thymidine phosphorylase inhibitor tipiracil (components of TAS-102) vs trifluridine alone [PDF]

, 2017

core   +1 more source

Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: Synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II

, 2014
Hriday Bera, Probir Kumar Ojha, Bee Jen Tan, Lingyi Sun, Anton V. Dolzhenko, Wai‐Keung Chui, Gigi Ngar Chee Chiu   +6 more
openalex   +2 more sources

Long-Term Restoration of Thymidine Phosphorylase Function and Nucleoside Homeostasis Using Hematopoietic Gene Therapy in a Murine Model of Mitochondrial Neurogastrointestinal Encephalomyopathy

Human Gene Therapy, 2016
Javier Torres-Torronteras, R. Cabrera-Pérez, Ignasi Barba, Carme Costa, Noemí de Luna, Antonio L. Andreu, J. Barquinero, Michio Hirano, Y. Cámara, R. Martí   +9 more
semanticscholar   +1 more source

Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies. [PDF]

PLoS One, 2019
Javaid S, Shaikh M, Fatima N, Choudhary MI.   +3 more
europepmc   +1 more source

Structural investigation of the thymidine phosphorylase from Salmonella typhimurium in the unliganded state and its complexes with thymidine and uridine.

Acta Crystallographica Section F Structural Biology Communications, 2016
V. Balaev, A. A. Lashkov, A. Gabdulkhakov, M. Dontsova, T. Seregina, A. Mironov, C. Betzel, A. Mikhailov   +7 more
semanticscholar   +1 more source

Mitochondrial Neurogastrointestinal Encephalomyopathy: Novel Pathogenic Mutation in Thymidine Phosphorylase Gene in a Patient from Cape Verde Islands. [PDF]

Case Rep Neurol Med, 2019
Falcão de Campos C, Oliveira Santos M, Roque R, Conceição I, de Carvalho M.   +4 more
europepmc   +1 more source

Tumor-associated macrophages confer resistance to chemotherapy (Trifluridine/Tipiracil) in digestive cancers by overexpressing thymidine phosphorylase

Marie Malier, Marie‐Hélène Laverrière, Maxime Henry, Malika Yakoubi, Pascale Bellaud, Cécile Arellano, Anthony Sébillot, Fabienne Thomas, Véronique Josserand, Édouard Girard, Gaël S. Roth, Arnaud Millet   +11 more
openalex   +2 more sources

Kinetics and mechanistic study of competitive inhibition of thymidine phosphorylase by 5-fluoruracil derivatives.

Colloids and Surfaces B: Biointerfaces, 2016
Manuela Petaccia, P. Gentili, Neva Besker, M. D’Abramo, L. Giansanti, F. Leonelli, A. La Bella, Denise Gradella Villalva, G. Mancini   +8 more
semanticscholar   +1 more source

Thymidine Phosphorylase Expression and Microvascular Density Correlation Analysis in Canine Mammary Tumor: Possible Prognostic Factor in Breast Cancer. [PDF]

Front Vet Sci, 2019
Zizzo N, Passantino G, D'alessio RM, Tinelli A, Lopresti G, Patruno R, Tricarico D, Maqoud F, Scala R, Zito FA, Ranieri G.   +10 more
europepmc   +1 more source

Effects of interferon-alpha on thymidine phosphorylase expression and apoptosis in human hepatocellular carcinoma SMMC-7721 cells

, 2009
Yongsheng Xiao, Jian Zhou, Jia Fan, Qi‐Man Sun, Yan Zhao, Qiong Xue, Zao‐Zhuo Shen, Zhao–You Tang   +7 more
openalex   +1 more source